SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		6 / 9 LEU A  76
VAL A  84
LYS A  99
LEU A 133
LEU A 145
LEU A 218
 None
 0.65A 1xkkA-4rgjA:
23.4		 1xkkA-4rgjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 11 LEU A 260
LEU A 264
ILE A 328
THR A 332
LEU A 155
 None
 1.37A 2ft9A-4rgjA:
undetectable		 2ft9A-4rgjA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 6 SER A 417
VAL A 100
TYR A 144
ASP A 420
 None
 0.90A 2x45A-4rgjA:
undetectable		 2x45A-4rgjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 7 SER A 417
VAL A 100
TYR A 144
ASP A 420
 None
 0.91A 2x45B-4rgjA:
undetectable		 2x45B-4rgjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 7 SER A 417
VAL A 100
TYR A 144
ASP A 420
 None
 0.88A 2x45C-4rgjA:
undetectable		 2x45C-4rgjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 7 SER A 417
VAL A 100
TYR A 144
ASP A 420
 None
 0.92A 3bu1A-4rgjA:
undetectable		 3bu1A-4rgjA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 12 VAL A  65
TYR A  96
TYR A  70
GLY A  72
GLU A  95
 None
 1.27A 3medA-4rgjA:
undetectable
3medB-4rgjA:
undetectable		 3medA-4rgjA:
22.52
3medB-4rgjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 6 GLU A 135
TYR A  70
VAL A  64
PHE A 137
 None
 1.15A 4a97E-4rgjA:
2.1		 4a97E-4rgjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 12 LYS A  99
LYS A 195
ASN A 198
ASP A 215
GLY A 217
 None
 0.74A 4an2A-4rgjA:
23.6		 4an2A-4rgjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 4 ILE A 278
LEU A 279
LYS A 280
ASN A 274
 None
 0.85A 4g19D-4rgjA:
undetectable		 4g19D-4rgjA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		8 / 12 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 133
LEU A 145
GLU A 154
ILE A 214
 None
 0.63A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		8 / 12 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
GLU A 154
ILE A 214
LEU A 218
 None
 0.65A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		9 / 12 GLY A  77
VAL A  84
LYS A  99
LEU A 133
LEU A 145
GLY A 153
GLU A 154
LEU A 200
ILE A 214
 None
 0.70A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		9 / 12 GLY A  77
VAL A  84
LYS A  99
LEU A 145
GLY A 153
GLU A 154
LEU A 200
ILE A 214
LEU A 218
 None
 0.70A 4ifgA-4rgjA:
42.5		 4ifgA-4rgjA:
68.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 8 SER A 265
CYH A 267
TYR A 261
PRO A 292
 None
 1.19A 4j7uD-4rgjA:
undetectable		 4j7uD-4rgjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		7 / 11 LEU A  76
GLY A  77
VAL A  84
ALA A  97
LYS A  99
ASN A 198
ASP A 215
 None
 0.92A 4o0sA-4rgjA:
25.5		 4o0sA-4rgjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 6 VAL A  84
ALA A  97
LYS A  99
LEU A 200
 None
 0.71A 4o0uA-4rgjA:
10.7		 4o0uA-4rgjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 6 LEU A  76
VAL A  84
ILE A 130
ILE A 213
 None
 0.42A 4tyjA-4rgjA:
20.4		 4tyjA-4rgjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 6 LEU A  76
VAL A  84
ILE A 213
ILE A 199
 None
 0.65A 4tyjA-4rgjA:
20.4		 4tyjA-4rgjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 12 ILE A 211
GLY A 180
ILE A 181
ARG A 172
LEU A 264
 None
 0.85A 5e72A-4rgjA:
undetectable		 5e72A-4rgjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 7 LEU A 309
PRO A 269
ILE A 262
LEU A 263
 None
 1.00A 5fxtA-4rgjA:
undetectable		 5fxtA-4rgjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		4 / 5 TYR A 142
GLU A  83
GLY A  82
SER A 102
 None
 0.85A 5jhdJ-4rgjA:
undetectable		 5jhdJ-4rgjA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 12 PHE A 354
SER A 265
GLN A 355
ILE A 173
ALA A 170
 None
 1.15A 5n0sB-4rgjA:
undetectable		 5n0sB-4rgjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		7 / 12 LEU A  76
GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
 None
 0.43A 5yu9A-4rgjA:
22.9		 5yu9A-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		6 / 12 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
 None
 0.39A 5yu9B-4rgjA:
23.2		 5yu9B-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		5 / 12 VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
 None
 0.37A 5yu9C-4rgjA:
23.1		 5yu9C-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4
(Plasmodium
falciparum) 		6 / 12 VAL A  84
ALA A  97
LYS A  99
LEU A 200
ASP A 215
LEU A 218
 None
 0.87A 5yu9D-4rgjA:
23.4		 5yu9D-4rgjA:
10.40