SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 11 ASP A 337
ARG A 237
PHE A 232
HIS A 340
ILE A 339
 None
None
None
SO4  A 506 (-3.3A)
None
 1.29A 1fkjA-4rgkA:
undetectable		 1fkjA-4rgkA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 ILE A  46
LEU A  50
SER A 341
ASN A 272
ILE A 274
 None
 1.29A 2e7fB-4rgkA:
undetectable		 2e7fB-4rgkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 11 ASP A 337
ARG A 237
PHE A 232
HIS A 340
ILE A 339
 None
None
None
SO4  A 506 (-3.3A)
None
 1.30A 2fkeA-4rgkA:
undetectable		 2fkeA-4rgkA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		4 / 6 SER A 193
ARG A 188
ARG A 186
ILE A 134
 None
 1.28A 2qeiA-4rgkA:
undetectable		 2qeiA-4rgkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 ILE A  46
LEU A  50
SER A 341
ASN A 272
ILE A 274
 None
 1.26A 2ycjA-4rgkA:
undetectable		 2ycjA-4rgkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 11 THR A 180
LEU A 159
VAL A 155
ILE A  86
ALA A 146
 None
 1.17A 2zbzA-4rgkA:
undetectable		 2zbzA-4rgkA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 LEU A 316
SER A 309
ILE A 276
ALA A 277
ASP A 337
 None
 1.25A 3vw1D-4rgkA:
undetectable		 3vw1D-4rgkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		4 / 5 PHE A 395
PHE A 111
ILE A 137
GLY A 136
 None
 0.88A 4ejjC-4rgkA:
undetectable		 4ejjC-4rgkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.88A 4fp9D-4rgkA:
undetectable		 4fp9D-4rgkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.82A 4fzvA-4rgkA:
undetectable		 4fzvA-4rgkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 ILE A  39
PHE A 214
TYR A 218
HIS A 335
TRP A 163
 None
 1.36A 4j03A-4rgkA:
undetectable		 4j03A-4rgkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 PHE A 111
PHE A 395
VAL A 393
SER A 382
GLY A 380
 None
 1.18A 4mm6A-4rgkA:
undetectable		 4mm6A-4rgkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ARG A 286
GLU A 310
TYR A 282
 None
 0.92A 4r29D-4rgkA:
undetectable		 4r29D-4rgkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 SER A 245
ARG A 304
ILE A 206
ASP A 296
ILE A  10
 None
 1.34A 4uroD-4rgkA:
undetectable		 4uroD-4rgkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
TYR A 356
 EDO  A 505 ( 4.3A)
None
None
 0.73A 5a7mA-4rgkA:
undetectable		 5a7mA-4rgkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
TYR A 356
 EDO  A 505 ( 4.3A)
None
None
 0.75A 5a7mB-4rgkA:
undetectable		 5a7mB-4rgkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 GLU A 343
HIS A 267
ASP A 325
 None
 0.86A 5c0oG-4rgkA:
undetectable		 5c0oG-4rgkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 9 ILE A  10
ALA A  13
ILE A  14
ALA A 300
LEU A 297
 None
 1.04A 5mvmA-4rgkA:
undetectable
5mvmE-4rgkA:
undetectable		 5mvmA-4rgkA:
12.68
5mvmE-4rgkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 10 ALA A 300
LEU A 297
ILE A  10
ALA A  13
ILE A  14
 None
 1.01A 5mvmD-4rgkA:
undetectable
5mvmE-4rgkA:
undetectable		 5mvmD-4rgkA:
12.68
5mvmE-4rgkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.79A 5zvgA-4rgkA:
undetectable		 5zvgA-4rgkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		3 / 3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.81A 5zvgB-4rgkA:
undetectable		 5zvgB-4rgkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4rgk UNCHARACTERIZED
PROTEIN
(Yersinia
pestis) 		5 / 12 VAL A  89
GLY A 329
ALA A 260
PHE A 333
ASN A 160
 None
 1.21A 6bqgA-4rgkA:
undetectable		 6bqgA-4rgkA:
11.30