SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		4 / 5 LEU A 227
ILE A 216
GLY A 192
HIS A 182
 None
None
None
UNL  A 401 ( 4.6A)
 0.88A 2otfA-4rglA:
undetectable		 2otfA-4rglA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		3 / 3 HIS A 112
MET A 191
MET A 116
 None
None
UNL  A 401 ( 4.7A)
 1.21A 2vj1A-4rglA:
0.2		 2vj1A-4rglA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		5 / 10 TRP A 203
THR A  51
ASN A  47
VAL A 212
LEU A 247
 None
 1.43A 3casA-4rglA:
undetectable		 3casA-4rglA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		4 / 8 ARG A  44
ARG A  48
MET A  97
GLU A  95
 None
 1.45A 3zmdA-4rglA:
7.0
3zmdB-4rglA:
7.1		 3zmdA-4rglA:
19.88
3zmdB-4rglA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		4 / 6 ILE A  13
ALA A 236
THR A 237
VAL A 240
 None
 0.74A 5eclD-4rglA:
undetectable		 5eclD-4rglA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		4 / 8 SER A 171
ILE A 199
LEU A 247
PRO A 167
 None
 1.05A 5u4sB-4rglA:
undetectable		 5u4sB-4rglA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC
(Desulfovibrio
alaskensis) 		4 / 7 ARG A  50
ARG A 193
ILE A  58
ALA A  54
 None
 0.76A 6ma7A-4rglA:
undetectable		 6ma7A-4rglA:
12.89