SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4rgp CSM6_III-A
(Streptococcus
mutans) 		5 / 12 ALA A 228
LEU A 109
LEU A  86
ILE A  83
PHE A 189
 None
 1.17A 1bsxA-4rgpA:
undetectable		 1bsxA-4rgpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4rgp CSM6_III-A
(Streptococcus
mutans) 		5 / 12 ALA A 228
LEU A 109
LEU A  86
ILE A  83
PHE A 189
 None
 1.17A 1bsxB-4rgpA:
undetectable		 1bsxB-4rgpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		5 / 12 LEU A  69
VAL A 245
VAL A  23
LEU A  40
LEU A  37
 None
 1.40A 1mx1E-4rgpA:
undetectable		 1mx1E-4rgpA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		3 / 3 ASP A  85
PHE A 242
ARG A  44
 None
 0.76A 2a3aA-4rgpA:
undetectable		 2a3aA-4rgpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 1.00A 3abkP-4rgpA:
undetectable
3abkW-4rgpA:
undetectable		 3abkP-4rgpA:
20.82
3abkW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 TYR A  16
ARG A  43
MET A  84
PHE A 240
 None
 1.38A 3af3A-4rgpA:
undetectable		 3af3A-4rgpA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 1.00A 3ag2C-4rgpA:
2.1		 3ag2C-4rgpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.94A 3ag2P-4rgpA:
2.1
3ag2W-4rgpA:
undetectable		 3ag2P-4rgpA:
20.82
3ag2W-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.94A 3ag4P-4rgpA:
2.0
3ag4W-4rgpA:
undetectable		 3ag4P-4rgpA:
20.82
3ag4W-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.99A 3asnP-4rgpA:
undetectable
3asnW-4rgpA:
undetectable		 3asnP-4rgpA:
20.82
3asnW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.97A 3asoP-4rgpA:
2.1
3asoW-4rgpA:
undetectable		 3asoP-4rgpA:
20.82
3asoW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.99A 3wg7C-4rgpA:
undetectable
3wg7J-4rgpA:
undetectable		 3wg7C-4rgpA:
20.82
3wg7J-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.98A 3wg7P-4rgpA:
undetectable
3wg7W-4rgpA:
undetectable		 3wg7P-4rgpA:
20.82
3wg7W-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.11A 4mi4A-4rgpA:
undetectable		 4mi4A-4rgpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.12A 4mi4B-4rgpA:
undetectable
4mi4C-4rgpA:
undetectable		 4mi4B-4rgpA:
23.13
4mi4C-4rgpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.12A 4mi4A-4rgpA:
undetectable
4mi4C-4rgpA:
undetectable		 4mi4A-4rgpA:
23.13
4mi4C-4rgpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 8 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.11A 4mj8A-4rgpA:
undetectable
4mj8C-4rgpA:
undetectable		 4mj8A-4rgpA:
24.43
4mj8C-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 8 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.15A 4mj8B-4rgpA:
undetectable
4mj8C-4rgpA:
undetectable		 4mj8B-4rgpA:
24.43
4mj8C-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.11A 4mj8C-4rgpA:
undetectable		 4mj8C-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		5 / 12 ASN A  72
TYR A 241
LYS A 244
VAL A  48
SER A  68
 None
 1.39A 4ot2A-4rgpA:
undetectable		 4ot2A-4rgpA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.04A 4r87I-4rgpA:
undetectable		 4r87I-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.94A 5x19P-4rgpA:
2.4		 5x19P-4rgpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 5 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.94A 5x1bP-4rgpA:
2.3		 5x1bP-4rgpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 7 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.94A 5x1fP-4rgpA:
2.4
5x1fW-4rgpA:
undetectable		 5x1fP-4rgpA:
20.82
5x1fW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		5 / 12 ASN A  72
TYR A 241
LYS A 244
VAL A  48
SER A  68
 None
 1.33A 6ci6A-4rgpA:
1.3		 6ci6A-4rgpA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4rgp CSM6_III-A
(Streptococcus
mutans) 		4 / 6 THR A 173
PRO A 176
GLN A 177
ILE A 170
 None
 1.23A 6ef6A-4rgpA:
undetectable		 6ef6A-4rgpA:
19.94