SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 MET A 146
ALA A 182
THR A 287
LEU A 272
LEU A 190
 None
 1.10A 1eiiA-4rgqA:
undetectable		 1eiiA-4rgqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 328
VAL A 334
TYR A 260
GLY A 333
LEU A 303
 EDO  A 411 ( 4.5A)
None
None
None
None
 1.23A 1fkoA-4rgqA:
undetectable		 1fkoA-4rgqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.82A 1grmA-4rgqA:
undetectable		 1grmA-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.83A 1grmB-4rgqA:
undetectable		 1grmB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.78A 1jnoA-4rgqA:
undetectable		 1jnoA-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.78A 1jnoB-4rgqA:
undetectable		 1jnoB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.76A 1jo3A-4rgqA:
undetectable		 1jo3A-4rgqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.75A 1jo3B-4rgqA:
undetectable		 1jo3B-4rgqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.74A 1jo4A-4rgqA:
undetectable		 1jo4A-4rgqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.74A 1jo4B-4rgqA:
undetectable		 1jo4B-4rgqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.75A 1magA-4rgqA:
undetectable		 1magA-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.75A 1magB-4rgqA:
undetectable		 1magB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.79A 1ng8A-4rgqA:
undetectable		 1ng8A-4rgqA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.79A 1ng8B-4rgqA:
undetectable		 1ng8B-4rgqA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.67A 1nrmA-4rgqA:
undetectable		 1nrmA-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.67A 1nrmB-4rgqA:
undetectable		 1nrmB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.76A 1nruA-4rgqA:
undetectable		 1nruA-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.77A 1nruB-4rgqA:
undetectable		 1nruB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.77A 1nt5A-4rgqA:
undetectable		 1nt5A-4rgqA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.77A 1nt5B-4rgqA:
undetectable		 1nt5B-4rgqA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.68A 1nt6A-4rgqA:
undetectable		 1nt6A-4rgqA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.68A 1nt6B-4rgqA:
undetectable		 1nt6B-4rgqA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A 229
CYH A 251
THR A 154
ILE A 153
VAL A 150
 None
ZN  A 403 ( 4.4A)
None
None
None
 1.18A 1pkvA-4rgqA:
undetectable
1pkvB-4rgqA:
undetectable		 1pkvA-4rgqA:
13.59
1pkvB-4rgqA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 150
SER A 229
CYH A 251
THR A 154
ILE A 153
 None
None
ZN  A 403 ( 4.4A)
None
None
 1.17A 1pkvA-4rgqA:
undetectable
1pkvB-4rgqA:
undetectable		 1pkvA-4rgqA:
13.59
1pkvB-4rgqA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 303
LEU A 328
HIS A 262
ILE A 315
LEU A 316
 None
EDO  A 411 ( 4.5A)
None
None
None
 1.14A 1tw4A-4rgqA:
undetectable		 1tw4A-4rgqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 239
LEU A 235
LEU A 232
ILE A 243
LEU A 241
 None
 1.14A 1tw4B-4rgqA:
undetectable		 1tw4B-4rgqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 115
TYR A  86
LYS A  90
 None
 1.04A 1uujB-4rgqA:
1.6		 1uujB-4rgqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A  86
GLU A  60
VAL A 112
TYR A  89
 None
None
NDP  A 401 ( 4.7A)
None
 1.11A 2fl5E-4rgqA:
undetectable
2fl5F-4rgqA:
undetectable		 2fl5E-4rgqA:
18.31
2fl5F-4rgqA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A 255
SER A 151
ALA A 155
GLY A 223
SER A 224
 None
K  A 402 ( 4.6A)
None
None
None
 1.23A 2xfsB-4rgqA:
1.7		 2xfsB-4rgqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 154
GLY A 223
ASP A 158
ILE A 315
LEU A 227
 None
 1.01A 3eeyJ-4rgqA:
undetectable		 3eeyJ-4rgqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 252
HIS A 226
ASP A 148
ILE A 149
 None
ZN  A 403 ( 3.2A)
ZN  A 403 ( 2.6A)
None
 0.94A 3fi0P-4rgqA:
undetectable		 3fi0P-4rgqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  16
ALA A  15
ASP A 130
THR A 131
VAL A 202
 None
 1.37A 4kq8A-4rgqA:
undetectable		 4kq8A-4rgqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 129
ILE A  81
GLY A  74
ILE A  73
VAL A 206
 None
 1.07A 4nptA-4rgqA:
undetectable		 4nptA-4rgqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 232
VAL A 334
ILE A 253
LEU A 303
ALA A 302
 None
 1.02A 4p65F-4rgqA:
undetectable
4p65H-4rgqA:
undetectable
4p65K-4rgqA:
undetectable
4p65L-4rgqA:
undetectable		 4p65F-4rgqA:
3.80
4p65H-4rgqA:
3.80
4p65K-4rgqA:
5.33
4p65L-4rgqA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A 279
SER A 143
TYR A 197
ASP A 148
GLY A 252
 None
EDO  A 408 (-3.6A)
EDO  A 408 ( 4.8A)
ZN  A 403 ( 2.6A)
None
 1.40A 4qb9F-4rgqA:
undetectable		 4qb9F-4rgqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LYS A 282
LYS A 281
LEU A 292
PHE A 294
 None
 1.23A 4yv5A-4rgqA:
undetectable		 4yv5A-4rgqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 221
SER A 222
SER A 113
PRO A 110
 K  A 402 ( 3.6A)
13P  A 404 (-2.6A)
NDP  A 401 (-2.6A)
EDO  A 405 (-4.0A)
 1.11A 5c6pA-4rgqA:
undetectable		 5c6pA-4rgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  84
GLY A  36
GLY A  76
GLY A  74
THR A  39
 None
NDP  A 401 (-3.1A)
None
None
NDP  A 401 (-3.6A)
 0.94A 5ehgC-4rgqA:
undetectable		 5ehgC-4rgqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 170
LYS A 160
SER A 171
ILE A 214
 None
 0.87A 5jhdE-4rgqA:
undetectable
5jhdG-4rgqA:
undetectable		 5jhdE-4rgqA:
20.11
5jhdG-4rgqA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  84
GLY A  36
GLY A  76
GLY A  74
THR A  39
 None
NDP  A 401 (-3.1A)
None
None
NDP  A 401 (-3.6A)
 0.96A 5kqrA-4rgqA:
undetectable		 5kqrA-4rgqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  84
GLY A  36
GLY A  76
GLY A  74
THR A  39
 None
NDP  A 401 (-3.1A)
None
None
NDP  A 401 (-3.6A)
 0.94A 5m5bA-4rgqA:
undetectable		 5m5bA-4rgqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 328
LEU A 303
ALA A 306
SER A 229
LEU A 232
 EDO  A 411 ( 4.5A)
None
None
None
None
 1.12A 5mwyA-4rgqA:
undetectable		 5mwyA-4rgqA:
23.64