SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 6 LYS A 145
GLU A 227
ARG A 138
LYS A 139
 None
 1.36A 1yc2A-4rgtA:
undetectable
1yc2B-4rgtA:
undetectable
1yc2E-4rgtA:
undetectable		 1yc2A-4rgtA:
22.76
1yc2B-4rgtA:
22.76
1yc2E-4rgtA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLU A 106
TYR A  47
VAL A 104
PHE A 166
ASP A 165
 None
 1.44A 2qeoA-4rgtA:
undetectable		 2qeoA-4rgtA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 6 GLU A 229
LYS A 186
LYS A 188
GLU A 202
 None
None
None
GAL  A 402 (-3.6A)
 1.27A 4a7tF-4rgtA:
undetectable		 4a7tF-4rgtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 LYS A 177
LEU A 178
GLU A 176
LEU A 228
 None
 1.31A 4k4yA-4rgtA:
undetectable		 4k4yA-4rgtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 4 LYS A 177
LEU A 178
GLU A 176
LEU A 228
 None
 1.34A 4k4yE-4rgtA:
undetectable		 4k4yE-4rgtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 LYS A 177
LEU A 178
GLU A 176
LEU A 228
 None
 1.34A 4k4yI-4rgtA:
undetectable		 4k4yI-4rgtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 221
LEU A 161
ILE A 189
ARG A 169
ILE A 224
 None
 1.09A 4x5jA-4rgtA:
undetectable		 4x5jA-4rgtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 172
LEU A 203
ARG A 169
 None
 0.61A 6fgcA-4rgtA:
undetectable		 6fgcA-4rgtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 172
LEU A 203
ARG A 169
 None
 0.60A 6fgdA-4rgtA:
undetectable		 6fgdA-4rgtA:
19.95