SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 6 PRO A 813
MET A 912
ALA A 915
GLU A 916
 None
None
GOL  A1302 ( 4.0A)
None
 1.44A 1qhyA-4rgwA:
undetectable		 1qhyA-4rgwA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN A 905
HIS A 823
ARG A 825
 None
 0.98A 1zlqA-4rgwA:
undetectable		 1zlqA-4rgwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 TYR A 909
HIS A 858
SER A 857
HIS A 627
 None
 1.25A 2vmyA-4rgwA:
undetectable
2vmyB-4rgwA:
undetectable		 2vmyA-4rgwA:
20.62
2vmyB-4rgwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 751
GLY A 804
PHE A1091
ASP A1092
HIS A 756
 None
 1.40A 3dlcA-4rgwA:
undetectable		 3dlcA-4rgwA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG A 890
ILE A 897
TRP A 837
GLU A 895
 None
 1.48A 3e7gA-4rgwA:
undetectable
3e7gB-4rgwA:
undetectable		 3e7gA-4rgwA:
21.14
3e7gB-4rgwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 GLU A 895
ARG A 890
ILE A 897
TRP A 837
 None
 1.49A 3e7gA-4rgwA:
undetectable
3e7gB-4rgwA:
undetectable		 3e7gA-4rgwA:
21.14
3e7gB-4rgwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG A 890
ILE A 897
TRP A 837
GLU A 895
 None
 1.47A 3e7gC-4rgwA:
undetectable
3e7gD-4rgwA:
undetectable		 3e7gC-4rgwA:
21.14
3e7gD-4rgwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLU A 895
ARG A 890
ILE A 897
TRP A 837
 None
 1.47A 3e7gC-4rgwA:
undetectable
3e7gD-4rgwA:
undetectable		 3e7gC-4rgwA:
21.14
3e7gD-4rgwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE A 721
ILE A 773
ASP A 799
ILE A 700
LEU A 775
 None
None
GOL  A1301 (-4.4A)
None
None
 1.05A 3o1cA-4rgwA:
undetectable		 3o1cA-4rgwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE A 721
ILE A 773
ASP A 799
ILE A 700
LEU A 775
 None
None
GOL  A1301 (-4.4A)
None
None
 1.09A 3qgzA-4rgwA:
undetectable		 3qgzA-4rgwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG A 795
LEU A 797
GLU A 796
 GOL  A1301 ( 4.6A)
GOL  A1301 (-4.4A)
None
 0.75A 4l3gF-4rgwA:
undetectable		 4l3gF-4rgwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 GLU A 895
ARG A 890
ILE A 897
TRP A 837
 None
 1.48A 4nosA-4rgwA:
undetectable
4nosB-4rgwA:
undetectable		 4nosA-4rgwA:
21.12
4nosB-4rgwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 6 GLU A 895
ARG A 890
ILE A 897
TRP A 837
 None
 1.46A 4nosC-4rgwA:
undetectable
4nosD-4rgwA:
undetectable		 4nosC-4rgwA:
21.12
4nosD-4rgwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 ALA A 871
TRP A 883
VAL A 884
 None
 0.34A 4w9nC-4rgwA:
undetectable		 4w9nC-4rgwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A 944
GLU A 916
ARG A 957
ALA A 958
SER A 817
 None
 1.05A 5ih0A-4rgwA:
undetectable		 5ih0A-4rgwA:
18.41