SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 10 GLY A  50
SER A 125
MET A 126
LEU A 217
HIS A 244
 None
 0.72A 1a8uB-4rgyA:
15.1		 1a8uB-4rgyA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.41A 1errB-4rgyA:
undetectable		 1errB-4rgyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 8 TRP A  58
GLY A 127
TYR A  85
SER A 125
 None
 1.02A 1maaD-4rgyA:
14.9		 1maaD-4rgyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 12 GLY A 150
GLY A 128
GLY A 123
ASP A 220
GLY A 212
 None
 0.91A 1n2xB-4rgyA:
2.2		 1n2xB-4rgyA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 12 GLY A 128
GLY A 130
LEU A 134
LEU A  47
LEU A 102
 None
 1.01A 1ya4A-4rgyA:
15.3		 1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 12 GLY A 130
LEU A 134
LEU A  47
LEU A 102
HIS A  49
 None
 0.98A 1ya4A-4rgyA:
15.3		 1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 8 TYR A  67
ARG A  66
GLY A 247
ALA A 251
 None
 0.87A 2a1hA-4rgyA:
undetectable
2a1hB-4rgyA:
undetectable		 2a1hA-4rgyA:
21.13
2a1hB-4rgyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		3 / 3 ASP A 220
PHE A 191
ARG A 223
 None
 0.89A 2a3aA-4rgyA:
undetectable		 2a3aA-4rgyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 5 LEU A 112
PHE A  46
VAL A  21
ALA A  74
 None
 1.20A 2cizA-4rgyA:
undetectable		 2cizA-4rgyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.44A 2jfaA-4rgyA:
undetectable		 2jfaA-4rgyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.38A 2qxsA-4rgyA:
undetectable		 2qxsA-4rgyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.40A 2qxsB-4rgyA:
undetectable		 2qxsB-4rgyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 12 TYR A  85
GLY A 123
GLY A 127
TYR A 129
LEU A  45
 None
 1.10A 3vywA-4rgyA:
undetectable		 3vywA-4rgyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.48A 4xi3B-4rgyA:
undetectable		 4xi3B-4rgyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 5 SER A 125
ALA A 151
HIS A 244
LEU A  51
 None
 1.43A 5dzkb-4rgyA:
2.0
5dzkp-4rgyA:
undetectable		 5dzkb-4rgyA:
20.80
5dzkp-4rgyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 5 SER A 125
ALA A 151
HIS A 244
LEU A  51
 None
 1.40A 5dzkc-4rgyA:
undetectable
5dzkq-4rgyA:
undetectable		 5dzkc-4rgyA:
20.80
5dzkq-4rgyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 8 LEU A 193
LEU A 134
THR A  86
GLN A 173
 None
 1.19A 5hbsA-4rgyA:
undetectable		 5hbsA-4rgyA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 8 LEU A 193
LEU A 134
ILE A 176
THR A  86
GLN A 173
 None
 1.45A 5ljbA-4rgyA:
undetectable		 5ljbA-4rgyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 7 LEU A   3
ILE A 253
TRP A  58
MET A  77
 None
 1.23A 5ljcA-4rgyA:
undetectable		 5ljcA-4rgyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		6 / 12 LEU A 148
LEU A 124
LEU A  48
LEU A  47
LEU A  45
LEU A 132
 None
 1.46A 5toaA-4rgyA:
undetectable		 5toaA-4rgyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 10 ARG A  82
PHE A  84
ILE A 154
GLY A 178
PHE A 177
 None
 1.43A 5x66D-4rgyA:
undetectable		 5x66D-4rgyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 8 GLU A 245
TRP A 246
ARG A  61
THR A  62
 None
 1.14A 6a4iA-4rgyA:
undetectable		 6a4iA-4rgyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		4 / 7 GLU A 245
TRP A 246
ARG A  61
THR A  62
 None
 1.07A 6a4iB-4rgyA:
undetectable		 6a4iB-4rgyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4rgy ESTERASE
(uncultured
bacterium
FLS12) 		5 / 12 GLY A  50
LEU A  51
ASP A 250
ILE A 253
VAL A  80
 None
 1.12A 6mhtA-4rgyA:
2.9		 6mhtA-4rgyA:
18.58