SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 9 GLY A 205
GLU A 176
TYR A 337
ILE A 201
HIS A 213
 None
 1.20A 1acjA-4rgzA:
undetectable		 1acjA-4rgzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 8 GLY A 205
GLU A 176
TYR A 337
HIS A 213
 None
 0.94A 1maaD-4rgzA:
undetectable		 1maaD-4rgzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 12 MET A   6
GLU A  72
ILE A 308
GLY A 236
LEU A 235
 None
 1.15A 2yjaB-4rgzA:
undetectable		 2yjaB-4rgzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 7 TYR A 164
VAL A 196
VAL A 241
ILE A 183
 None
 1.32A 3ms9B-4rgzA:
undetectable		 3ms9B-4rgzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  60
GLN A  16
HIS A  13
GLY A  59
 None
 1.02A 3pp1A-4rgzA:
undetectable		 3pp1A-4rgzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 12 MET A   6
GLU A  72
ILE A 308
GLY A 236
LEU A 235
 None
 1.12A 4j26A-4rgzA:
undetectable		 4j26A-4rgzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		3 / 3 GLY A 335
GLU A 333
THR A 302
 None
ZN  A 401 (-3.9A)
None
 0.51A 4kouA-4rgzA:
undetectable		 4kouA-4rgzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 7 ALA A 180
ASP A 224
ARG A 221
GLY A 173
 None
 0.90A 5bs8A-4rgzA:
undetectable
5bs8C-4rgzA:
undetectable
5bs8D-4rgzA:
undetectable		 5bs8A-4rgzA:
21.59
5bs8C-4rgzA:
21.59
5bs8D-4rgzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 7 ALA A 180
ASP A 224
ARG A 221
GLY A 173
 None
 0.85A 5btgA-4rgzA:
undetectable
5btgC-4rgzA:
undetectable
5btgD-4rgzA:
undetectable		 5btgA-4rgzA:
21.59
5btgC-4rgzA:
21.59
5btgD-4rgzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 12 MET A   6
GLU A  72
ILE A 308
GLY A 236
LEU A 235
 None
 1.13A 5gs4A-4rgzA:
undetectable		 5gs4A-4rgzA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 7 ASP A 240
GLY A 303
GLY A 305
HIS A 311
 ZN  A 401 (-2.3A)
None
None
ZN  A 402 ( 4.8A)
 1.02A 5n9xA-4rgzA:
undetectable		 5n9xA-4rgzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 9 SER A 197
ALA A 193
VAL A 159
ALA A 155
SER A 239
 None
 1.12A 6bklA-4rgzA:
undetectable
6bklB-4rgzA:
undetectable
6bklC-4rgzA:
undetectable
6bklD-4rgzA:
undetectable		 6bklA-4rgzA:
5.59
6bklB-4rgzA:
5.59
6bklC-4rgzA:
5.59
6bklD-4rgzA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		4 / 6 SER A 239
SER A 197
ALA A 193
ALA A 155
 None
 0.97A 6bocA-4rgzA:
undetectable
6bocB-4rgzA:
undetectable
6bocC-4rgzA:
undetectable
6bocD-4rgzA:
undetectable		 6bocA-4rgzA:
5.59
6bocB-4rgzA:
5.59
6bocC-4rgzA:
5.59
6bocD-4rgzA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4rgz XAA-PRO
AMINOPEPTIDASE
(Thermococcus
sibiricus) 		5 / 12 LEU A 171
GLY A 208
ILE A 227
VAL A 247
ILE A 220
 None
 1.03A 6difA-4rgzA:
undetectable		 6difA-4rgzA:
12.50