SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A 320
ILE A 196
ARG A 215
TYR A 327
 None
 1.38A 1rk3A-4rh0A:
undetectable		 1rk3A-4rh0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 LEU A 154
LEU A 181
VAL A 172
GLY A 230
TYR A 227
 None
None
EEM  A 401 (-3.9A)
None
None
 1.25A 1y4lB-4rh0A:
undetectable		 1y4lB-4rh0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 GLY A 146
TYR A 175
ARG A 193
VAL A 222
GLU A 137
 None
 1.37A 2fl5A-4rh0A:
undetectable
2fl5B-4rh0A:
undetectable
2fl5F-4rh0A:
undetectable		 2fl5A-4rh0A:
21.92
2fl5B-4rh0A:
18.90
2fl5F-4rh0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 6 ILE A 144
SER A 142
ARG A  68
ILE A 118
 None
None
SO4  A 403 (-3.0A)
None
 1.14A 2q72A-4rh0A:
undetectable		 2q72A-4rh0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 LEU A 320
ILE A 196
ARG A 215
TYR A 327
 None
 1.46A 2zlcA-4rh0A:
undetectable		 2zlcA-4rh0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 6 GLN A 251
PHE A 250
PHE A 332
LEU A 257
 None
 1.09A 3ablP-4rh0A:
undetectable
3ablW-4rh0A:
undetectable		 3ablP-4rh0A:
22.46
3ablW-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 PRO A  85
ILE A  84
TYR A 125
TYR A  82
 None
 1.13A 3d9lA-4rh0A:
undetectable
3d9lY-4rh0A:
undetectable		 3d9lA-4rh0A:
16.89
3d9lY-4rh0A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A  92
ILE A 144
VAL A 145
GLY A 146
ILE A 109
 SF4  A 409 ( 4.0A)
None
None
None
None
 0.87A 3ekqA-4rh0A:
undetectable		 3ekqA-4rh0A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 6 GLY A  66
THR A  88
GLU A  12
GLU A  14
 None
SO4  A 403 (-2.8A)
None
None
 1.07A 3fpjA-4rh0A:
undetectable		 3fpjA-4rh0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A 282
HIS A  93
LEU A 291
GLY A 208
PRO A 207
 None
 1.14A 3ozwB-4rh0A:
undetectable		 3ozwB-4rh0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ARG A 298
HIS A 272
TYR A 312
 None
EEM  A 401 ( 4.7A)
None
 1.23A 4fu8A-4rh0A:
undetectable		 4fu8A-4rh0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ARG A 298
HIS A 272
TYR A 312
 None
EEM  A 401 ( 4.7A)
None
 1.31A 4fu9A-4rh0A:
undetectable		 4fu9A-4rh0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 TYR A  96
CYH A  97
TYR A  98
SER A 195
ILE A 270
 EEM  A 401 ( 4.6A)
SF4  A 409 (-2.1A)
EEM  A 401 (-4.1A)
EEM  A 401 (-2.4A)
EEM  A 401 ( 4.3A)
 1.21A 4k37A-4rh0A:
11.0		 4k37A-4rh0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 6 LEU A 216
PHE A 194
THR A 173
VAL A 145
 None
 1.03A 4udaA-4rh0A:
undetectable		 4udaA-4rh0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 ALA A 140
THR A 141
PRO A  78
SER A  79
ALA A  80
 None
SO4  A 403 (-3.0A)
None
None
None
 1.21A 4ypmA-4rh0A:
undetectable		 4ypmA-4rh0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 4 ILE A 270
ARG A 193
TYR A 339
GLU A 268
 EEM  A 401 ( 4.3A)
None
None
None
 1.38A 4zzbD-4rh0A:
undetectable		 4zzbD-4rh0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ARG A 193
TYR A 339
GLU A 268
 None
 0.69A 4zzbE-4rh0A:
undetectable		 4zzbE-4rh0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 6 GLN A 251
PHE A 250
PHE A 332
LEU A 257
 None
 1.09A 5b1bC-4rh0A:
undetectable
5b1bJ-4rh0A:
undetectable		 5b1bC-4rh0A:
22.46
5b1bJ-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 12 TYR A 227
PHE A 194
PHE A 171
LEU A 182
HIS A 180
 None
 1.16A 5v5zA-4rh0A:
undetectable		 5v5zA-4rh0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 TYR A 327
ARG A 326
MET A 324
LEU A 320
 None
 1.28A 5x19J-4rh0A:
undetectable		 5x19J-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 TYR A 327
ARG A 326
MET A 324
LEU A 320
 None
 1.24A 5x1bJ-4rh0A:
undetectable		 5x1bJ-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 5 TYR A 327
ARG A 326
MET A 324
LEU A 320
 None
 1.40A 6nknJ-4rh0A:
undetectable		 6nknJ-4rh0A:
12.95