SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE A1431
ALA A1736
GLY A1738
PHE A1713
LEU A1706
 None
 1.42A 1brpA-4rh7A:
undetectable		 1brpA-4rh7A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 THR A3395
LEU A3399
LEU A3406
GLN A3409
 None
 1.22A 1fbmA-4rh7A:
undetectable		 1fbmA-4rh7A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE A1788
PHE A1740
ILE A1761
ALA A1736
SER A1785
 None
 1.27A 1fm4A-4rh7A:
undetectable		 1fm4A-4rh7A:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE A2208
ARG A2194
GLY A2195
LEU A2176
ALA A2152
 None
 1.21A 1gseA-4rh7A:
undetectable		 1gseA-4rh7A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 PRO A1687
ASP A1741
ASN A2067
ASP A2071
 None
MG  A4402 ( 2.3A)
AOV  A4401 ( 4.8A)
AOV  A4401 ( 3.1A)
 1.29A 1hpkA-4rh7A:
undetectable		 1hpkA-4rh7A:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 THR A4105
VAL A4111
LEU A4114
ALA A4115
LEU A4044
 None
 0.98A 1jinA-4rh7A:
undetectable		 1jinA-4rh7A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 9 ASP A2055
SER A1981
ALA A1983
ASP A2098
ASP A2057
 MG  A4404 (-3.5A)
ATP  A4403 (-2.8A)
None
None
None
 1.49A 1m4dB-4rh7A:
undetectable		 1m4dB-4rh7A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 VAL A2316
SER A2324
VAL A2381
LEU A2356
LEU A2397
 None
 1.47A 1mx1E-4rh7A:
undetectable		 1mx1E-4rh7A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 CYH A1715
THR A1790
GLY A1738
ILE A1727
PHE A1728
 None
AOV  A4401 ( 4.6A)
None
None
None
 1.35A 1oltA-4rh7A:
undetectable		 1oltA-4rh7A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 MET A1756
GLY A3756
LEU A3762
GLN A3752
LEU A3779
 None
 1.42A 1p93C-4rh7A:
undetectable		 1p93C-4rh7A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A1904
SER A2049
TRP A2051
LEU A1939
LEU A1996
 None
 1.11A 1s19A-4rh7A:
undetectable		 1s19A-4rh7A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A1500
ASN A1501
LEU A1503
ALA A1504
LEU A1457
 None
 1.37A 2aa6A-4rh7A:
undetectable		 2aa6A-4rh7A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 SER A2204
PHE A2208
ALA A2152
LEU A2192
 None
 1.01A 2bxkA-4rh7A:
undetectable		 2bxkA-4rh7A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2260
LEU A2504
PRO A2448
VAL A2449
 None
 1.04A 2dqyC-4rh7A:
undetectable		 2dqyC-4rh7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2856
TYR A3213
THR A2874
LEU A2876
 None
 1.06A 2dyrA-4rh7A:
undetectable
2dyrJ-4rh7A:
undetectable		 2dyrA-4rh7A:
9.49
2dyrJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2856
TYR A3213
THR A2874
LEU A2876
 None
 1.06A 2eijA-4rh7A:
undetectable
2eijJ-4rh7A:
undetectable		 2eijA-4rh7A:
9.49
2eijJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2856
TYR A3213
THR A2874
LEU A2876
 None
 1.05A 2eilA-4rh7A:
undetectable
2eilJ-4rh7A:
undetectable		 2eilA-4rh7A:
9.49
2eilJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE A4031
SER A4116
HIS A2415
LEU A2366
LEU A2363
 None
 1.34A 2hc4A-4rh7A:
undetectable		 2hc4A-4rh7A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 LEU A3263
ASN A3391
ARG A3222
 None
 0.94A 2qhfA-4rh7A:
undetectable		 2qhfA-4rh7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A4180
LEU A4183
PHE A4179
ILE A4217
ALA A4202
 None
 1.02A 2v0mC-4rh7A:
undetectable		 2v0mC-4rh7A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ILE A3881
GLY A3884
ARG A3877
LEU A3998
 None
 0.87A 2vctA-4rh7A:
undetectable		 2vctA-4rh7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ILE A3881
GLY A3884
ARG A3877
LEU A3998
 None
 0.83A 2vctB-4rh7A:
undetectable		 2vctB-4rh7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ILE A3881
GLY A3884
ARG A3877
LEU A3998
 None
 0.85A 2vctC-4rh7A:
undetectable		 2vctC-4rh7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 9 LEU A3792
LEU A3821
LEU A3724
ALA A3811
PHE A3817
 None
 1.22A 2vcvE-4rh7A:
undetectable		 2vcvE-4rh7A:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 SER A1842
THR A1906
PHE A1918
ILE A1848
SER A1852
 None
 1.25A 2vdyB-4rh7A:
undetectable		 2vdyB-4rh7A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ILE A1758
TYR A3927
ALA A3872
THR A3843
LEU A3896
 None
 1.40A 2x2nD-4rh7A:
undetectable		 2x2nD-4rh7A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 ARG A1423
GLU A1420
SER A1785
 None
 0.88A 2xctD-4rh7A:
undetectable		 2xctD-4rh7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.32A 2y69C-4rh7A:
undetectable
2y69J-4rh7A:
undetectable		 2y69C-4rh7A:
6.13
2y69J-4rh7A:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 LEU A2504
ILE A2466
TRP A2460
TYR A2442
 None
 1.49A 2zlcA-4rh7A:
undetectable		 2zlcA-4rh7A:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 SER A2669
GLU A2713
ASP A2783
 None
ADP  A4406 ( 4.3A)
None
 0.65A 2zulA-4rh7A:
undetectable		 2zulA-4rh7A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.34A 3abmC-4rh7A:
undetectable
3abmJ-4rh7A:
undetectable		 3abmC-4rh7A:
6.13
3abmJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2856
TYR A3213
THR A2874
LEU A2876
 None
 1.07A 3abmA-4rh7A:
undetectable
3abmJ-4rh7A:
undetectable		 3abmA-4rh7A:
9.49
3abmJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.35A 3abmP-4rh7A:
undetectable
3abmW-4rh7A:
undetectable		 3abmP-4rh7A:
6.13
3abmW-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.34A 3ag3C-4rh7A:
undetectable
3ag3J-4rh7A:
undetectable		 3ag3C-4rh7A:
6.13
3ag3J-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLN A2774
ALA A2701
PHE A2765
GLY A2648
LEU A2729
 None
 1.47A 3aobC-4rh7A:
undetectable		 3aobC-4rh7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A4180
ILE A4217
SER A4218
PHE A4249
ILE A4284
 None
 1.08A 3cd2A-4rh7A:
undetectable		 3cd2A-4rh7A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.35A 3ce6A-4rh7A:
undetectable		 3ce6A-4rh7A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.35A 3ce6B-4rh7A:
undetectable		 3ce6B-4rh7A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.33A 3ce6C-4rh7A:
undetectable		 3ce6C-4rh7A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 SER A2669
GLU A2713
ASP A2783
 None
ADP  A4406 ( 4.3A)
None
 0.67A 3dmhA-4rh7A:
undetectable		 3dmhA-4rh7A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 ALA A3209
THR A3212
CYH A2862
 None
 0.76A 3e4eA-4rh7A:
undetectable		 3e4eA-4rh7A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ASN A1807
ASN A3781
ILE A1761
GLN A1762
LEU A1811
 None
 1.14A 3eeyB-4rh7A:
undetectable		 3eeyB-4rh7A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ALA A2674
LEU A2644
GLU A2713
SER A2650
LEU A2712
 None
None
ADP  A4406 ( 4.3A)
None
None
 1.43A 3eigA-4rh7A:
undetectable		 3eigA-4rh7A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.36A 3g1uC-4rh7A:
undetectable		 3g1uC-4rh7A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 ARG A2639
GLU A2525
ASP A2563
 None
 0.84A 3g2oA-4rh7A:
undetectable		 3g2oA-4rh7A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2007
GLU A2095
THR A2096
 None
None
MG  A4404 ( 2.9A)
None
 1.41A 3glqA-4rh7A:
undetectable		 3glqA-4rh7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2007
GLU A2095
THR A2096
 None
None
MG  A4404 ( 2.9A)
None
 1.37A 3glqB-4rh7A:
undetectable		 3glqB-4rh7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2397
LEU A2331
LYS A2330
ILE A2402
LEU A2358
 None
 1.09A 3hj3B-4rh7A:
undetectable		 3hj3B-4rh7A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 9 TYR A1664
LEU A1613
GLN A1544
PHE A1547
VAL A1551
 None
 1.48A 3jwqA-4rh7A:
undetectable		 3jwqA-4rh7A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 9 VAL A2172
GLY A2170
GLN A2133
ASN A2174
GLY A2175
 None
 1.42A 3kmoA-4rh7A:
undetectable		 3kmoA-4rh7A:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 ASP A2537
LEU A2506
ILE A2526
PHE A2572
GLU A2530
 None
 1.43A 3ko0A-4rh7A:
undetectable
3ko0B-4rh7A:
undetectable
3ko0C-4rh7A:
undetectable
3ko0D-4rh7A:
undetectable		 3ko0A-4rh7A:
2.91
3ko0B-4rh7A:
2.91
3ko0C-4rh7A:
2.91
3ko0D-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 GLU A2530
LEU A2506
ILE A2526
PHE A2572
ASP A2537
 None
 1.37A 3ko0C-4rh7A:
undetectable
3ko0D-4rh7A:
undetectable
3ko0E-4rh7A:
undetectable
3ko0F-4rh7A:
undetectable		 3ko0C-4rh7A:
2.91
3ko0D-4rh7A:
2.91
3ko0E-4rh7A:
2.91
3ko0F-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 ASP A2537
LEU A2506
ILE A2526
PHE A2572
GLU A2530
 None
 1.40A 3ko0C-4rh7A:
undetectable
3ko0D-4rh7A:
undetectable
3ko0E-4rh7A:
undetectable
3ko0F-4rh7A:
undetectable		 3ko0C-4rh7A:
2.91
3ko0D-4rh7A:
2.91
3ko0E-4rh7A:
2.91
3ko0F-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 GLU A2530
LEU A2506
ILE A2526
PHE A2572
ASP A2537
 None
 1.38A 3ko0E-4rh7A:
undetectable
3ko0F-4rh7A:
undetectable
3ko0G-4rh7A:
undetectable
3ko0H-4rh7A:
undetectable		 3ko0E-4rh7A:
2.91
3ko0F-4rh7A:
2.91
3ko0G-4rh7A:
2.91
3ko0H-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 GLU A2530
LEU A2506
ILE A2526
PHE A2572
ASP A2537
 None
 1.40A 3ko0G-4rh7A:
undetectable
3ko0H-4rh7A:
undetectable
3ko0I-4rh7A:
undetectable
3ko0J-4rh7A:
undetectable		 3ko0G-4rh7A:
2.91
3ko0H-4rh7A:
2.91
3ko0I-4rh7A:
2.91
3ko0J-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 LEU A2506
ILE A2526
PHE A2572
GLU A2530
ASP A2537
 None
 1.43A 3ko0O-4rh7A:
undetectable
3ko0P-4rh7A:
undetectable
3ko0Q-4rh7A:
undetectable
3ko0R-4rh7A:
undetectable		 3ko0O-4rh7A:
2.91
3ko0P-4rh7A:
2.91
3ko0Q-4rh7A:
2.91
3ko0R-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 10 ASP A2537
LEU A2506
ILE A2526
PHE A2572
GLU A2530
 None
 1.43A 3ko0O-4rh7A:
undetectable
3ko0P-4rh7A:
undetectable
3ko0Q-4rh7A:
undetectable
3ko0R-4rh7A:
undetectable		 3ko0O-4rh7A:
2.91
3ko0P-4rh7A:
2.91
3ko0Q-4rh7A:
2.91
3ko0R-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 ASP A2537
GLU A2530
LEU A2506
ILE A2526
PHE A2572
 None
 1.41A 3ko0Q-4rh7A:
undetectable
3ko0R-4rh7A:
undetectable
3ko0S-4rh7A:
undetectable
3ko0T-4rh7A:
undetectable		 3ko0Q-4rh7A:
2.91
3ko0R-4rh7A:
2.91
3ko0S-4rh7A:
2.91
3ko0T-4rh7A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 THR A2334
LEU A2354
VAL A2355
VAL A2316
 None
 1.03A 3l63A-4rh7A:
undetectable		 3l63A-4rh7A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A3525
LEU A3551
ARG A3561
ILE A3559
 None
 1.30A 3ln1D-4rh7A:
undetectable		 3ln1D-4rh7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ASP A2031
SER A2080
LEU A1437
ASP A1435
 None
 1.04A 3m0wE-4rh7A:
undetectable
3m0wF-4rh7A:
undetectable
3m0wG-4rh7A:
undetectable
3m0wH-4rh7A:
undetectable		 3m0wE-4rh7A:
2.96
3m0wF-4rh7A:
2.96
3m0wG-4rh7A:
2.96
3m0wH-4rh7A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 LEU A1939
LYS A1944
VAL A1946
LEU A1992
GLU A1938
 None
 1.33A 3m8pA-4rh7A:
undetectable
3m8pB-4rh7A:
undetectable		 3m8pA-4rh7A:
9.81
3m8pB-4rh7A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 THR A2419
THR A2418
GLY A1979
SER A2167
SER A2100
 None
 1.13A 3mg02-4rh7A:
undetectable
3mg0V-4rh7A:
undetectable		 3mg02-4rh7A:
4.67
3mg0V-4rh7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 GLN A2380
THR A2007
GLU A2095
THR A2096
 None
None
MG  A4404 ( 2.9A)
None
 1.37A 3n58A-4rh7A:
undetectable		 3n58A-4rh7A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 GLY A1877
LEU A1879
LEU A1880
ILE A1897
 None
 0.80A 3nbqB-4rh7A:
undetectable		 3nbqB-4rh7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 GLY A1877
LEU A1879
LEU A1880
ILE A1897
 None
 0.80A 3nbqC-4rh7A:
undetectable		 3nbqC-4rh7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 9 ILE A1473
LEU A1454
PHE A1458
LEU A1514
GLY A1460
 None
 1.49A 3nxuB-4rh7A:
undetectable		 3nxuB-4rh7A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 THR A3212
GLN A2871
TYR A3213
ILE A2858
 None
 1.27A 3peoG-4rh7A:
undetectable		 3peoG-4rh7A:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A4232
VAL A4286
THR A4282
LEU A4220
VAL A4245
 None
 1.18A 3sp9B-4rh7A:
undetectable		 3sp9B-4rh7A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 GLN A1900
GLU A1935
LYS A1932
 None
 1.03A 3su9A-4rh7A:
undetectable		 3su9A-4rh7A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 PHE A2287
PHE A2305
ALA A2304
LEU A2289
 None
 1.21A 3t3zC-4rh7A:
undetectable		 3t3zC-4rh7A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ARG A2027
VAL A1721
VAL A1754
GLN A3757
 None
 1.11A 3uy4A-4rh7A:
undetectable		 3uy4A-4rh7A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 VAL A2163
SER A2429
GLY A2197
ARG A2205
 None
 1.21A 3v4tA-4rh7A:
undetectable
3v4tD-4rh7A:
undetectable		 3v4tA-4rh7A:
8.08
3v4tD-4rh7A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A4183
ILE A4217
ILE A4072
LEU A4170
LEU A4163
 None
 0.97A 3vw1B-4rh7A:
undetectable		 3vw1B-4rh7A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ILE A3311
VAL A3335
LEU A3340
ALA A3317
ILE A3326
 None
 1.10A 3w67C-4rh7A:
undetectable		 3w67C-4rh7A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2730
LEU A2710
GLN A2716
ILE A2726
PHE A2677
 None
 1.47A 4a79A-4rh7A:
undetectable		 4a79A-4rh7A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2730
LEU A2710
GLN A2716
ILE A2726
PHE A2677
 None
 1.44A 4a79B-4rh7A:
undetectable		 4a79B-4rh7A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 LEU A2730
LEU A2710
GLN A2716
ILE A2726
PHE A2677
 None
 1.46A 4a7aA-4rh7A:
undetectable		 4a7aA-4rh7A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 PHE A3243
ILE A3211
GLU A3196
GLU A3249
VAL A2878
 None
 1.29A 4a97B-4rh7A:
undetectable
4a97C-4rh7A:
undetectable		 4a97B-4rh7A:
6.68
4a97C-4rh7A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 LEU A2417
ALA A2404
ILE A2288
LYS A2416
 None
 1.17A 4eixA-4rh7A:
undetectable		 4eixA-4rh7A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 ALA A4182
ASN A4181
LEU A4183
ASP A4177
 None
 1.06A 4g24A-4rh7A:
undetectable		 4g24A-4rh7A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A3583
PHE A3693
ALA A3572
GLY A3699
LEU A3698
 None
 1.30A 4j7xB-4rh7A:
undetectable		 4j7xB-4rh7A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2397
LEU A2331
LYS A2330
ILE A2402
LEU A2358
 None
 1.04A 4ky8A-4rh7A:
undetectable		 4ky8A-4rh7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2397
LEU A2331
LYS A2330
ILE A2402
LEU A2358
 None
 0.99A 4ky8C-4rh7A:
undetectable		 4ky8C-4rh7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2397
LEU A2331
LYS A2330
ILE A2402
LEU A2358
 None
 1.08A 4ky8D-4rh7A:
undetectable		 4ky8D-4rh7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2397
LEU A2331
LYS A2330
ILE A2402
LEU A2358
 None
 1.05A 4ky8E-4rh7A:
undetectable		 4ky8E-4rh7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 VAL A2355
ILE A2400
LEU A2374
LEU A2378
 None
 1.04A 4l1wA-4rh7A:
undetectable		 4l1wA-4rh7A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ASN A2362
LEU A2417
LEU A2427
ASN A2199
 None
 0.96A 4n09C-4rh7A:
undetectable		 4n09C-4rh7A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ILE A2190
HIS A2185
ALA A2216
LEU A2238
PHE A2213
 None
 1.06A 4pbhA-4rh7A:
undetectable		 4pbhA-4rh7A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ASP A2055
GLY A2056
ASP A2057
GLY A1979
ASP A2098
 MG  A4404 (-3.5A)
None
None
None
None
 1.26A 4pevB-4rh7A:
undetectable		 4pevB-4rh7A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 SER A2666
TYR A2618
ASP A3343
 None
 0.81A 4rp8C-4rh7A:
undetectable		 4rp8C-4rh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 LEU A2382
GLY A2386
ILE A2400
ILE A2402
PRO A2286
 None
 0.92A 4xdrA-4rh7A:
undetectable		 4xdrA-4rh7A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLY A1984
VAL A2169
PHE A2421
ILE A2424
 ATP  A4403 (-2.9A)
None
None
None
 1.12A 4xv2B-4rh7A:
undetectable		 4xv2B-4rh7A:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 SER A3892
GLU A3739
GLU A3850
 None
 0.67A 4ymgB-4rh7A:
undetectable		 4ymgB-4rh7A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 VAL A3791
ILE A3506
PRO A3819
THR A3393
 None
 1.26A 4ze1A-4rh7A:
undetectable		 4ze1A-4rh7A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 VAL A4100
LEU A4107
SER A4108
GLU A4110
 None
 0.99A 4zphA-4rh7A:
undetectable
4zphB-4rh7A:
undetectable		 4zphA-4rh7A:
7.30
4zphB-4rh7A:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LYS A1844
LEU A1851
SER A1852
VAL A1899
 None
 1.24A 5a6iA-4rh7A:
undetectable		 5a6iA-4rh7A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 ASP A3684
ASN A3654
PHE A3661
 None
 0.74A 5dsgB-4rh7A:
undetectable		 5dsgB-4rh7A:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 MET A2816
HIS A2859
GLY A2810
 None
 0.84A 5gwzB-4rh7A:
undetectable		 5gwzB-4rh7A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 GLN A3759
ASP A1720
GLY A3758
LEU A3762
 None
 1.04A 5hwaA-4rh7A:
undetectable		 5hwaA-4rh7A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 SER A1536
ASP A1602
SER A1478
GLU A1480
GLU A1482
 None
 1.49A 5iqeC-4rh7A:
undetectable		 5iqeC-4rh7A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 SER A2870
THR A2868
ARG A3341
ILE A3386
 None
 0.75A 5jhdE-4rh7A:
undetectable
5jhdG-4rh7A:
undetectable		 5jhdE-4rh7A:
5.89
5jhdG-4rh7A:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A2644
SER A2645
ARG A2642
ILE A2640
 None
 1.05A 5jw1A-4rh7A:
undetectable		 5jw1A-4rh7A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A2868
SER A3385
ASP A2714
 None
 0.82A 5kvaA-4rh7A:
undetectable		 5kvaA-4rh7A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A2868
SER A3385
ASP A2714
 None
 0.81A 5kvaB-4rh7A:
undetectable		 5kvaB-4rh7A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 LEU A3368
GLU A3333
LEU A3314
ILE A3355
 None
 0.98A 5mzjA-4rh7A:
undetectable		 5mzjA-4rh7A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ALA A2404
VAL A2403
GLY A2298
GLU A2293
PHE A2305
 None
None
ADP  A4405 (-3.5A)
ADP  A4405 (-4.9A)
None
 0.86A 5n5dA-4rh7A:
undetectable		 5n5dA-4rh7A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 TYR A1281
SER A1286
TRP A1349
 None
 0.98A 5n8jB-4rh7A:
undetectable		 5n8jB-4rh7A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 TYR A1281
SER A1286
TRP A1349
 None
 0.99A 5n8jA-4rh7A:
undetectable		 5n8jA-4rh7A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 TYR A1281
SER A1286
TRP A1349
 None
 0.97A 5n8jD-4rh7A:
undetectable		 5n8jD-4rh7A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A1921
PHE A1918
ASP A1914
TRP A1864
 None
 1.17A 5om3A-4rh7A:
undetectable
5om3B-4rh7A:
undetectable		 5om3A-4rh7A:
2.41
5om3B-4rh7A:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 ARG A2347
TYR A1318
GLU A1322
SER A1326
 None
 1.25A 5umwA-4rh7A:
undetectable
5umwF-4rh7A:
undetectable		 5umwA-4rh7A:
2.24
5umwF-4rh7A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 ILE A2611
LEU A2667
LEU A2602
ALA A2587
GLY A2673
 None
 1.05A 5uxdB-4rh7A:
undetectable		 5uxdB-4rh7A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 GLY A1982
GLU A2095
ILE A2424
GLN A2285
 ATP  A4403 (-3.3A)
MG  A4404 ( 2.9A)
None
None
 1.03A 5vlmD-4rh7A:
undetectable		 5vlmD-4rh7A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.35A 5wauC-4rh7A:
undetectable
5wauJ-4rh7A:
undetectable		 5wauC-4rh7A:
6.13
5wauJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 5 ARG A2532
PHE A2556
LEU A2552
PHE A2548
 None
 1.33A 5xdqC-4rh7A:
undetectable
5xdqJ-4rh7A:
undetectable		 5xdqC-4rh7A:
6.13
5xdqJ-4rh7A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 LEU A3399
GLN A3402
LEU A3406
LEU A3524
 None
 1.14A 5yvnA-4rh7A:
undetectable		 5yvnA-4rh7A:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 ARG A3396
SER A3507
ASP A3508
HIS A3574
 None
 1.37A 5zhmA-4rh7A:
undetectable		 5zhmA-4rh7A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 ARG A1726
ILE A1727
SER A1723
 None
 0.88A 5zw2A-4rh7A:
undetectable		 5zw2A-4rh7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 VAL A1610
PHE A1632
ILE A1545
VAL A1551
HIS A1605
 None
 1.22A 6ap6A-4rh7A:
undetectable		 6ap6A-4rh7A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 VAL A1610
PHE A1632
ILE A1545
VAL A1551
HIS A1605
 None
 1.22A 6ap6B-4rh7A:
undetectable		 6ap6B-4rh7A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 PHE A3527
ARG A3529
ALA A3499
GLN A3532
 None
 1.29A 6b89A-4rh7A:
undetectable		 6b89A-4rh7A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 VAL A1484
LEU A1705
MET A1634
ARG A1708
 None
 1.24A 6brdB-4rh7A:
undetectable		 6brdB-4rh7A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 LEU A1511
ASN A1658
LEU A1539
 None
 0.71A 6exiD-4rh7A:
undetectable		 6exiD-4rh7A:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.36A 6f3nA-4rh7A:
undetectable		 6f3nA-4rh7A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.36A 6f3nC-4rh7A:
undetectable		 6f3nC-4rh7A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 4 GLN A2380
THR A2383
THR A2418
HIS A2097
 None
MG  A4404 ( 4.6A)
None
None
 1.36A 6f3nD-4rh7A:
undetectable		 6f3nD-4rh7A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A1999
ALA A1942
LYS A1944
 None
 0.58A 6fgcA-4rh7A:
undetectable		 6fgcA-4rh7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A1999
ALA A1942
LYS A1944
 None
 0.58A 6fgdA-4rh7A:
undetectable		 6fgdA-4rh7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 11 ILE A4284
LEU A4269
PRO A4270
LEU A4304
PHE A4303
 None
 1.25A 6hupA-4rh7A:
undetectable
6hupB-4rh7A:
undetectable		 6hupA-4rh7A:
2.16
6hupB-4rh7A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 10 ASP A2360
GLY A2294
TYR A2432
ASP A2487
THR A2485
 None
ADP  A4405 (-2.9A)
None
None
None
 1.49A 6mn1B-4rh7A:
undetectable		 6mn1B-4rh7A:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.18A 6mn4B-4rh7A:
undetectable		 6mn4B-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 ASP A3239
ARG A3241
GLU A3266
ASP A3262
 None
 1.06A 6mn4D-4rh7A:
undetectable		 6mn4D-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 8 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.11A 6mn4D-4rh7A:
undetectable		 6mn4D-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 7 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.20A 6mn4F-4rh7A:
undetectable		 6mn4F-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 ILE A2627
LEU A2628
MET A2873
THR A2874
 ADP  A4406 (-4.0A)
ADP  A4406 (-3.8A)
ADP  A4406 (-4.5A)
None
 0.89A 6nmfN-4rh7A:
undetectable
6nmfW-4rh7A:
undetectable		 6nmfN-4rh7A:
9.49
6nmfW-4rh7A:
3.11