SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
5 / 10 LEU A 651
VAL A 700
VAL A 688
TYR A 780
GLY A 701
None
1.46A 1fkoA-4rhbA:
undetectable
1fkoA-4rhbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
3 / 3 SER A 530
GLY A 548
ARG A 480
None
0.68A 1t9wA-4rhbA:
undetectable
1t9wA-4rhbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
3 / 3 ASP A 488
ARG A 511
ASP A 543
None
0.97A 1vptA-4rhbA:
undetectable
1vptA-4rhbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 5 LEU A 540
ILE A 582
LEU A 606
SER A 605
None
1.00A 2byoA-4rhbA:
2.6
2byoA-4rhbA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 8 ARG A 551
GLY A 591
ASP A 593
ARG A 589
None
0.97A 2f9wA-4rhbA:
undetectable
2f9wB-4rhbA:
undetectable
2f9wA-4rhbA:
17.83
2f9wB-4rhbA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 6 SER A 578
ASP A 611
LYS A 490
GLU A 509
None
0.92A 2vn1B-4rhbA:
undetectable
2vn1B-4rhbA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
3 / 3 SER A 588
ASP A 629
ASP A 633
None
0.90A 4mwzA-4rhbA:
undetectable
4mwzA-4rhbA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 6 ASP A 569
ALA A 571
THR A 505
TYR A 504
None
1.47A 4w5qA-4rhbA:
undetectable
4w5qA-4rhbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 6 ASP A 569
ALA A 571
THR A 505
TYR A 504
None
1.47A 4z4fA-4rhbA:
undetectable
4z4fA-4rhbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 5 ASP A 569
ALA A 571
THR A 505
TYR A 504
None
1.47A 4z4hA-4rhbA:
undetectable
4z4hA-4rhbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 6 ASP A 569
ALA A 571
THR A 505
TYR A 504
None
1.47A 4z4iA-4rhbA:
undetectable
4z4iA-4rhbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 7 ARG A 520
THR A 472
THR A 586
ARG A 551
None
0.96A 5vc0A-4rhbA:
undetectable
5vc0A-4rhbA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli)
4 / 7 GLY A 591
GLN A 460
TYR A 528
ASP A 524
None
0.99A 5vlmG-4rhbA:
undetectable
5vlmG-4rhbA:
14.07