SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 10 ALA A  22
ILE A  78
GLU A  27
ILE A  30
TYR A  71
 None
 0.79A 2dm6A-4rheA:
4.7
2dm6B-4rheA:
5.1		 2dm6A-4rheA:
22.33
2dm6B-4rheA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 11 ALA A  12
MET A 100
LEU A 138
ILE A 130
THR A  14
 None
None
None
None
FMN  A 301 (-4.1A)
 1.34A 2zzaB-4rheA:
undetectable		 2zzaB-4rheA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A  67
SER A  64
PHE A  66
ILE A  56
 None
 0.93A 3ko0B-4rheA:
undetectable		 3ko0B-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A  67
SER A  64
PHE A  66
ILE A  56
 None
 0.98A 3ko0S-4rheA:
undetectable		 3ko0S-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 11 PRO A  60
LEU A  39
VAL A  90
ALA A  91
PHE A  87
 None
 1.38A 3n23C-4rheA:
3.5		 3n23C-4rheA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 6 ILE A 122
LEU A  25
ILE A  13
CYH A 103
 None
 0.89A 4asdA-4rheA:
undetectable		 4asdA-4rheA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 8 GLY A  15
GLY A  18
VAL A  52
GLU A  51
 FMN  A 301 (-3.5A)
None
None
None
 0.69A 4fgzB-4rheA:
undetectable		 4fgzB-4rheA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 6 VAL A 188
LEU A 192
CYH A 103
LEU A  11
 None
 1.11A 5hrqB-4rheA:
undetectable
5hrqI-4rheA:
undetectable
5hrqJ-4rheA:
undetectable		 5hrqB-4rheA:
11.63
5hrqI-4rheA:
7.18
5hrqJ-4rheA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  44
GLY A  18
GLY A  15
ASP A 182
VAL A 185
 None
None
FMN  A 301 (-3.5A)
None
None
 0.93A 5kqsA-4rheA:
3.7		 5kqsA-4rheA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 4 SER A  95
ALA A  96
GLN A  35
THR A  10
 None
 1.12A 5n0rA-4rheA:
2.1		 5n0rA-4rheA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 5 SER A  95
ALA A  96
GLN A  35
THR A  10
 None
 1.11A 5n0tA-4rheA:
2.4		 5n0tA-4rheA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  44
GLY A  18
GLY A  15
ASP A 182
VAL A 185
 None
None
FMN  A 301 (-3.5A)
None
None
 0.87A 5wz1B-4rheA:
3.6		 5wz1B-4rheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  44
GLY A  18
GLY A  15
ASP A 182
VAL A 185
 None
None
FMN  A 301 (-3.5A)
None
None
 0.86A 5wz2A-4rheA:
3.8		 5wz2A-4rheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  44
GLY A  18
GLY A  15
ASP A 182
VAL A 185
 None
None
FMN  A 301 (-3.5A)
None
None
 0.88A 5wz2B-4rheA:
3.8		 5wz2B-4rheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Colwellia
psychrerythraea) 		4 / 5 ILE A 194
LEU A 189
THR A  10
LEU A  11
 None
 0.87A 6nmpN-4rheA:
undetectable
6nmpW-4rheA:
undetectable		 6nmpN-4rheA:
17.27
6nmpW-4rheA:
19.30