SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 697
VAL A 695
GLY A 694
VAL A 120
PHE A 353
 None
 1.24A 1a27A-4rhhA:
undetectable		 1a27A-4rhhA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.97A 1c6zB-4rhhA:
undetectable		 1c6zB-4rhhA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 279
ILE A 193
ALA A 245
ALA A 141
LEU A 136
 None
 1.09A 1cbsA-4rhhA:
3.2		 1cbsA-4rhhA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.06A 1dz4A-4rhhA:
undetectable		 1dz4A-4rhhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.09A 1dz4B-4rhhA:
undetectable		 1dz4B-4rhhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 163
GLY A 186
SER A 171
THR A 170
 None
 1.37A 1icvA-4rhhA:
undetectable
1icvB-4rhhA:
undetectable		 1icvA-4rhhA:
15.11
1icvB-4rhhA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 576
GLY A 512
ILE A 574
ALA A 573
PHE A 595
 None
 1.07A 1ri4A-4rhhA:
undetectable		 1ri4A-4rhhA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.04A 1t85A-4rhhA:
undetectable		 1t85A-4rhhA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.07A 1t88B-4rhhA:
undetectable		 1t88B-4rhhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 133
LYS A 121
PRO A 124
ALA A 122
 None
 1.34A 2ejgA-4rhhA:
undetectable		 2ejgA-4rhhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 133
LYS A 121
PRO A 124
ALA A 122
 None
 1.48A 2ejgB-4rhhA:
undetectable		 2ejgB-4rhhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.04A 2feuA-4rhhA:
undetectable		 2feuA-4rhhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 317
TYR A 316
GLY A  15
THR A 320
 None
 1.02A 2g70B-4rhhA:
undetectable		 2g70B-4rhhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.96A 2hs1A-4rhhA:
undetectable		 2hs1A-4rhhA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.03A 2m56A-4rhhA:
undetectable		 2m56A-4rhhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 422
GLY A 419
HIS A 426
ASP A 467
 None
None
None
CA  A 801 (-3.4A)
 1.36A 2oxtC-4rhhA:
undetectable		 2oxtC-4rhhA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A 349
ARG A 693
ILE A 680
LEU A 699
THR A 696
 None
TRS  A 803 (-3.4A)
None
None
None
 1.23A 2v0mA-4rhhA:
undetectable		 2v0mA-4rhhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 230
ARG A 183
ILE A 231
 None
 0.68A 2xn5B-4rhhA:
undetectable		 2xn5B-4rhhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 277
GLN A 288
GLN A 243
ILE A 143
 None
 1.10A 2xz5B-4rhhA:
undetectable
2xz5E-4rhhA:
undetectable		 2xz5B-4rhhA:
15.48
2xz5E-4rhhA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.16A 2zawA-4rhhA:
undetectable		 2zawA-4rhhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 346
GLY A 335
TYR A 691
HIS A 396
 None
None
TRS  A 803 (-4.6A)
TRS  A 803 (-3.9A)
 0.96A 3af0A-4rhhA:
undetectable		 3af0A-4rhhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 638
VAL A 348
TYR A 581
LEU A 699
GLU A 575
 None
 1.47A 3bgrA-4rhhA:
undetectable
3bgrB-4rhhA:
0.7		 3bgrA-4rhhA:
22.25
3bgrB-4rhhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.07A 3fwgA-4rhhA:
undetectable		 3fwgA-4rhhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLN A 458
LEU A 460
GLU A 457
LEU A 533
 None
 0.84A 3h5gA-4rhhA:
undetectable
3h5gC-4rhhA:
undetectable		 3h5gA-4rhhA:
3.69
3h5gC-4rhhA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 566
ASP A 498
ARG A 611
 None
 0.93A 3k13C-4rhhA:
undetectable		 3k13C-4rhhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.99A 3k4vD-4rhhA:
undetectable		 3k4vD-4rhhA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.97A 3oxcB-4rhhA:
undetectable		 3oxcB-4rhhA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.94A 3tkgB-4rhhA:
undetectable		 3tkgB-4rhhA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.96A 3tkgD-4rhhA:
undetectable		 3tkgD-4rhhA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 349
ARG A 693
SER A 686
THR A 696
ALA A 682
 None
TRS  A 803 (-3.4A)
None
None
None
 1.34A 3ua1A-4rhhA:
undetectable		 3ua1A-4rhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 349
SER A 686
ILE A 685
THR A 696
ALA A 682
 None
 1.21A 3ua1A-4rhhA:
undetectable		 3ua1A-4rhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.11A 3wrhE-4rhhA:
undetectable		 3wrhE-4rhhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.10A 3wrjE-4rhhA:
undetectable		 3wrjE-4rhhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 354
TYR A 316
HIS A  10
VAL A 102
 None
 1.03A 4a97D-4rhhA:
2.5		 4a97D-4rhhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLU A 354
TYR A 316
HIS A  10
VAL A 102
 None
 1.12A 4a97H-4rhhA:
0.7		 4a97H-4rhhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASN A 566
HIS A 605
PRO A 572
LEU A 501
LEU A 510
 None
 1.02A 4ac0A-4rhhA:
2.1		 4ac0A-4rhhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 162
ILE A  45
GLY A  46
ILE A  58
 None
 0.68A 4eatA-4rhhA:
undetectable		 4eatA-4rhhA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 368
VAL A 332
ASN A 342
GLY A 399
 TRS  A 802 (-3.8A)
None
None
None
 0.94A 4ejjB-4rhhA:
undetectable		 4ejjB-4rhhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.07A 4g3rB-4rhhA:
undetectable		 4g3rB-4rhhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 110
ALA A 109
ILE A  45
ILE A  89
ILE A  96
 None
 0.98A 4jecB-4rhhA:
undetectable		 4jecB-4rhhA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.09A 4kkyX-4rhhA:
undetectable		 4kkyX-4rhhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 PHE A 353
LEU A 295
VAL A 102
VAL A  14
 None
 1.06A 4l49A-4rhhA:
undetectable		 4l49A-4rhhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 SER A 418
THR A 485
GLU A 387
ASP A 377
GLY A 487
 None
 1.49A 4qb9C-4rhhA:
undetectable		 4qb9C-4rhhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 418
THR A 485
GLU A 387
ASP A 377
GLY A 487
 None
 1.36A 4qb9E-4rhhA:
undetectable		 4qb9E-4rhhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 273
PHE A 268
PHE A 267
HIS A 269
 None
 1.33A 4uciA-4rhhA:
undetectable		 4uciA-4rhhA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 1.07A 4umjA-4rhhA:
2.4		 4umjA-4rhhA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A 576
ALA A 511
ALA A 573
ILE A 574
LEU A 577
ALA A 520
 None
 1.29A 5bw4B-4rhhA:
undetectable		 5bw4B-4rhhA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 205
SER A 207
LYS A  84
 None
 1.42A 5os7A-4rhhA:
undetectable		 5os7A-4rhhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 395
MET A 424
HIS A 423
 None
TRS  A 803 (-4.4A)
None
 1.03A 5uunA-4rhhA:
undetectable		 5uunA-4rhhA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 100
LEU A  31
PHE A   7
ALA A 141
ALA A 103
 None
 1.18A 5vc0A-4rhhA:
undetectable		 5vc0A-4rhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 1.05A 6g31D-4rhhA:
3.0		 6g31D-4rhhA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 0.93A 6g31J-4rhhA:
undetectable		 6g31J-4rhhA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 205
SER A 207
LYS A  84
 None
 1.42A 6gmdB-4rhhA:
undetectable		 6gmdB-4rhhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 439
ILE A 440
ALA A 447
ASP A 125
 None
 0.97A 6hu9a-4rhhA:
1.6
6hu9e-4rhhA:
undetectable		 6hu9a-4rhhA:
23.04
6hu9e-4rhhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 MET A 309
ALA A 312
TYR A 316
TYR A 317
THR A 320
 None
 1.22A 6hu9N-4rhhA:
undetectable		 6hu9N-4rhhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rhh BETA-XYLOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 439
ILE A 440
ALA A 447
ASP A 125
 None
 0.90A 6hu9m-4rhhA:
undetectable
6hu9q-4rhhA:
undetectable		 6hu9m-4rhhA:
23.04
6hu9q-4rhhA:
10.46