SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 165
GLY A 168
LEU A 161
VAL A 154
PHE A 195
 None
 1.16A 1dfoA-4rhmA:
undetectable		 1dfoA-4rhmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 165
GLY A 168
LEU A 161
VAL A 154
PHE A 195
 None
 1.16A 1dfoB-4rhmA:
undetectable		 1dfoB-4rhmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 165
GLY A 168
LEU A 161
VAL A 154
PHE A 195
 None
 1.16A 1dfoD-4rhmA:
undetectable		 1dfoD-4rhmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4rhm ARGINASE
(Trypanosoma
brucei) 		3 / 3 GLY A  24
ARG A  15
TYR A 300
 None
 0.73A 2opxA-4rhmA:
undetectable		 2opxA-4rhmA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 12 ILE A  60
GLN A  47
SER A 289
PHE A  45
LEU A  46
 None
 1.07A 3dzyA-4rhmA:
undetectable		 3dzyA-4rhmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 10 GLY A 242
GLY A 243
LEU A 228
VAL A 176
ILE A 202
 None
 1.05A 3em4V-4rhmA:
undetectable		 3em4V-4rhmA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 6 ILE A 264
ASP A 237
GLY A 124
VAL A 227
 None
 0.99A 3n3iA-4rhmA:
undetectable		 3n3iA-4rhmA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 6 ALA A 231
ALA A 287
LEU A 283
THR A 284
 None
 0.98A 4dtzA-4rhmA:
undetectable		 4dtzA-4rhmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 9 TYR A 267
GLY A 124
ASP A 149
SER A 155
ARG A 162
 None
None
MN  A 402 (-2.5A)
None
None
 1.44A 4gcpA-4rhmA:
0.0		 4gcpA-4rhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 9 TYR A 267
GLY A 124
ASP A 149
SER A 155
ARG A 162
 None
None
MN  A 402 (-2.5A)
None
None
 1.45A 4gcpB-4rhmA:
0.0		 4gcpB-4rhmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 5 THR A 304
GLY A 258
VAL A 219
PRO A 218
 None
 1.18A 4grkA-4rhmA:
undetectable		 4grkA-4rhmA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4rhm ARGINASE
(Trypanosoma
brucei) 		3 / 3 MET A  35
MET A  84
TYR A 269
 None
 1.35A 4p6xI-4rhmA:
undetectable		 4p6xI-4rhmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		3 / 3 ASP A 237
GLY A 268
ASP A 224
 None
None
MN  A 402 (-3.0A)
 0.70A 4xdtA-4rhmA:
undetectable		 4xdtA-4rhmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 12 PRO A 271
GLY A  32
GLU A  87
LEU A  41
GLY A 121
 None
 0.84A 4yvgA-4rhmA:
undetectable		 4yvgA-4rhmA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 8 ASP A 149
ASP A 226
ASP A 224
ASP A 237
 MN  A 402 (-2.5A)
MN  A 402 (-2.1A)
MN  A 402 (-3.0A)
None
 0.97A 5cfsA-4rhmA:
undetectable		 5cfsA-4rhmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 6 PHE A 148
SER A 182
VAL A 181
ASP A 153
 None
 1.25A 5hesA-4rhmA:
undetectable		 5hesA-4rhmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 7 ASP A 149
HIS A 147
ASP A 224
ASP A 153
 MN  A 402 (-2.5A)
None
MN  A 402 (-3.0A)
None
 0.92A 5nnwD-4rhmA:
undetectable		 5nnwD-4rhmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 7 ASP A 149
HIS A 147
ASP A 224
ASP A 153
 MN  A 402 (-2.5A)
None
MN  A 402 (-3.0A)
None
 0.99A 5no9D-4rhmA:
undetectable		 5no9D-4rhmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		3 / 3 PHE A   5
ASP A  86
LYS A   4
 None
 0.85A 6awtD-4rhmA:
undetectable		 6awtD-4rhmA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 8 VAL A  12
TYR A 115
HIS A  61
ASN A  80
 None
 1.33A 6gneB-4rhmA:
3.5		 6gneB-4rhmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 4 LYS A 290
LEU A 250
ALA A 287
LEU A 249
 None
 1.46A 6gnrA-4rhmA:
undetectable		 6gnrA-4rhmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		4 / 4 LYS A 290
LEU A 250
ALA A 287
LEU A 249
 None
 1.46A 6gnrB-4rhmA:
undetectable		 6gnrB-4rhmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4rhm ARGINASE
(Trypanosoma
brucei) 		5 / 11 LEU A  28
GLY A 263
PHE A  45
ILE A 292
ILE A 296
 None
 1.06A 6gp2A-4rhmA:
undetectable		 6gp2A-4rhmA:
10.17