SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 TRP A 169
ALA A 221
VAL A 203
 None
 0.96A 1bdwA-4rhoA:
undetectable
1bdwB-4rhoA:
undetectable		 1bdwA-4rhoA:
5.67
1bdwB-4rhoA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 LEU A 120
LEU A 132
MET A   1
GLU A   2
 PGE  A 301 ( 4.8A)
PGE  A 301 ( 4.7A)
PGE  A 301 (-4.9A)
None
 1.26A 2kuhA-4rhoA:
undetectable		 2kuhA-4rhoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ALA A 187
ALA A 133
THR A 137
VAL A 191
GLY A 199
 None
 1.14A 2ve3B-4rhoA:
undetectable		 2ve3B-4rhoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.33A 3qelA-4rhoA:
undetectable
3qelB-4rhoA:
undetectable		 3qelA-4rhoA:
22.31
3qelB-4rhoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 9 VAL A 148
VAL A 147
VAL A 191
ILE A 201
ALA A 150
 None
 0.96A 4fwdA-4rhoA:
undetectable		 4fwdA-4rhoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.38A 4pe5A-4rhoA:
undetectable
4pe5B-4rhoA:
undetectable		 4pe5A-4rhoA:
17.35
4pe5B-4rhoA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.32A 4pe5C-4rhoA:
undetectable
4pe5D-4rhoA:
undetectable		 4pe5C-4rhoA:
17.35
4pe5D-4rhoA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.32A 5ewjA-4rhoA:
undetectable
5ewjB-4rhoA:
undetectable		 5ewjA-4rhoA:
21.37
5ewjB-4rhoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rho UNCHARACTERIZED
PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A 173
ALA A 150
ILE A   3
PHE A 116
PRO A 165
 None
 1.32A 5ewjC-4rhoA:
undetectable
5ewjD-4rhoA:
undetectable		 5ewjC-4rhoA:
21.37
5ewjD-4rhoA:
22.83