SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 119
VAL A 125
LEU A 131
GLU A 163
LEU A 134
 LEU  A 119 ( 0.6A)
VAL  A 125 (-0.6A)
LEU  A 131 ( 0.6A)
GLU  A 163 ( 0.6A)
LEU  A 134 ( 0.6A)
 1.09A 1sn5B-4rhyA:
undetectable
1sn5D-4rhyA:
undetectable		 1sn5B-4rhyA:
21.05
1sn5D-4rhyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 131
GLU A 163
LEU A 134
LEU A 119
VAL A 125
 LEU  A 131 ( 0.6A)
GLU  A 163 ( 0.6A)
LEU  A 134 ( 0.6A)
LEU  A 119 ( 0.6A)
VAL  A 125 (-0.6A)
 1.10A 1sn5B-4rhyA:
undetectable
1sn5D-4rhyA:
undetectable		 1sn5B-4rhyA:
21.05
1sn5D-4rhyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 152
LEU A  28
ALA A  38
LEU A  75
GLN A  34
 LEU  A 152 ( 0.6A)
LEU  A  28 ( 0.6A)
ALA  A  38 ( 0.0A)
LEU  A  75 ( 0.6A)
GLN  A  34 ( 0.6A)
 1.25A 1tbfA-4rhyA:
undetectable		 1tbfA-4rhyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 201
VAL A 176
TYR A 183
ILE A  23
 TYR  A 201 ( 1.3A)
VAL  A 176 (-0.6A)
TYR  A 183 ( 1.3A)
ILE  A  23 ( 0.7A)
 1.27A 2xz5B-4rhyA:
undetectable
2xz5E-4rhyA:
undetectable		 2xz5B-4rhyA:
21.70
2xz5E-4rhyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  23
TYR A 201
VAL A 176
TYR A 183
 ILE  A  23 ( 0.7A)
TYR  A 201 ( 1.3A)
VAL  A 176 (-0.6A)
TYR  A 183 ( 1.3A)
 1.31A 2xz5D-4rhyA:
undetectable
2xz5E-4rhyA:
undetectable		 2xz5D-4rhyA:
21.70
2xz5E-4rhyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 151
LEU A 181
GLY A 178
GLY A 180
 LEU  A 151 ( 0.5A)
LEU  A 181 (-0.5A)
GLY  A 178 ( 0.0A)
GLY  A 180 ( 0.0A)
 0.81A 3si7C-4rhyA:
undetectable
3si7D-4rhyA:
undetectable		 3si7C-4rhyA:
23.29
3si7D-4rhyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 121
ARG A  77
ILE A  79
ALA A  78
 VAL  A 121 ( 0.6A)
ARG  A  77 ( 0.6A)
ILE  A  79 ( 0.7A)
ALA  A  78 ( 0.0A)
 0.84A 4lv9B-4rhyA:
undetectable		 4lv9B-4rhyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 169
LEU A 152
ILE A 120
PHE A  71
TYR A 179
 PHE  A 169 ( 1.3A)
LEU  A 152 ( 0.6A)
ILE  A 120 ( 0.7A)
PHE  A  71 ( 1.3A)
TYR  A 179 ( 1.3A)
 1.44A 5dlvA-4rhyA:
undetectable		 5dlvA-4rhyA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 182
GLY A  67
ASP A 123
ASP A 126
 ASP  A 182 ( 0.5A)
GLY  A  67 (-0.0A)
ASP  A 123 (-0.6A)
ASP  A 126 (-0.5A)
 1.15A 5e72A-4rhyA:
undetectable		 5e72A-4rhyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 194
SER A 191
THR A  29
VAL A  26
 GLY  A 194 ( 0.0A)
SER  A 191 ( 0.0A)
THR  A  29 ( 0.8A)
VAL  A  26 ( 0.6A)
 1.21A 5ysiA-4rhyA:
undetectable		 5ysiA-4rhyA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		6 / 10 VAL A 121
LEU A  61
LEU A  59
LEU A  40
TYR A 166
LEU A  75
 VAL  A 121 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  59 ( 0.5A)
LEU  A  40 ( 0.6A)
TYR  A 166 ( 1.3A)
LEU  A  75 ( 0.6A)
 1.13A 6f5uA-4rhyA:
undetectable
6f5uB-4rhyA:
undetectable		 6f5uA-4rhyA:
20.93
6f5uB-4rhyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  77
ALA A  76
GLN A  34
ILE A  37
 ARG  A  77 ( 0.6A)
ALA  A  76 ( 0.0A)
GLN  A  34 ( 0.6A)
ILE  A  37 ( 0.7A)
 1.28A 6g9bA-4rhyA:
undetectable
6g9bB-4rhyA:
undetectable		 6g9bA-4rhyA:
20.93
6g9bB-4rhyA:
18.04