SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 4rhz CRY23AA1
CRY37AA1
(Bacillus
thuringiensis;
Bacillus
thuringiensis) 		4 / 4 THR B  32
PRO B  34
THR A 247
PRO A 245
 None
 1.19A 1a7yA-4rhzB:
undetectable
1a7yC-4rhzB:
undetectable		 1a7yA-4rhzB:
8.74
1a7yC-4rhzB:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rhz CRY23AA1
(Bacillus
thuringiensis) 		4 / 6 GLY A 224
GLN A 155
VAL A 258
ALA A 255
 None
 0.84A 1p6kA-4rhzA:
undetectable		 1p6kA-4rhzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4rhz CRY23AA1
(Bacillus
thuringiensis) 		4 / 7 TYR A 159
THR A 125
THR A 126
VAL A 114
 None
 1.17A 1tv8A-4rhzA:
undetectable		 1tv8A-4rhzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4rhz CRY23AA1
(Bacillus
thuringiensis) 		5 / 12 ALA A  91
GLY A 215
GLY A  88
ILE A  95
CYH A 167
 None
 1.05A 1x1aA-4rhzA:
undetectable		 1x1aA-4rhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4rhz CRY23AA1
(Bacillus
thuringiensis) 		5 / 12 VAL A 110
SER A 253
LEU A 225
LEU A 249
LEU A 260
 None
 1.03A 1ya4C-4rhzA:
undetectable		 1ya4C-4rhzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4rhz CRY23AA1
(Bacillus
thuringiensis) 		4 / 8 TYR A 159
THR A 125
THR A 126
VAL A 114
 None
 1.15A 2fb2A-4rhzA:
undetectable		 2fb2A-4rhzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4rhz CRY23AA1
CRY37AA1
(Bacillus
thuringiensis) 		4 / 8 TYR B 121
ALA B  29
THR A 247
LEU A 249
 None
 1.04A 2wx2B-4rhzB:
undetectable		 2wx2B-4rhzB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4rhz CRY37AA1
(Bacillus
thuringiensis) 		4 / 6 TYR B 121
VAL B 106
SER B 100
THR B 105
 None
 1.11A 3tj7A-4rhzB:
undetectable
3tj7B-4rhzB:
undetectable		 3tj7A-4rhzB:
19.05
3tj7B-4rhzB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4rhz CRY37AA1
(Bacillus
thuringiensis) 		4 / 6 VAL B 106
SER B 100
THR B 105
TYR B 121
 None
 1.14A 3tj7C-4rhzB:
undetectable
3tj7D-4rhzB:
undetectable		 3tj7C-4rhzB:
19.05
3tj7D-4rhzB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4rhz CRY37AA1
(Bacillus
thuringiensis) 		3 / 3 GLU B  52
GLY B  19
SER B  54
 None
 0.57A 4b53B-4rhzB:
2.1		 4b53B-4rhzB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4rhz CRY23AA1
CRY37AA1
(Bacillus
thuringiensis) 		5 / 12 TYR B 121
ALA B  29
THR A 247
LEU A 249
THR A  55
 None
 1.16A 5tl8A-4rhzB:
undetectable		 5tl8A-4rhzB:
15.45