SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ri0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 ILE A 332
PRO A 333
ASP A 335
ILE A 228
THR A 321
 None
 1.45A 1kijA-4ri0A:
undetectable		 1kijA-4ri0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		4 / 5 VAL A 192
VAL A 193
GLN A 203
ARG A 360
 None
 1.22A 3bjwH-4ri0A:
undetectable		 3bjwH-4ri0A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		4 / 5 VAL A 192
VAL A 193
GLN A 203
ARG A 360
 None
 1.27A 3bjwB-4ri0A:
undetectable		 3bjwB-4ri0A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		4 / 4 THR A 270
VAL A 310
GLY A 306
THR A 188
 None
 0.88A 3cflA-4ri0A:
undetectable		 3cflA-4ri0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 ILE A 273
LEU A 242
GLY A 318
ASN A 320
ILE A 317
 None
 0.95A 4o1eB-4ri0A:
undetectable		 4o1eB-4ri0A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		4 / 6 SER A 375
ASP A 406
ARG A 438
GLY A 439
 None
 1.06A 5cdqA-4ri0A:
undetectable
5cdqC-4ri0A:
undetectable
5cdqD-4ri0A:
undetectable		 5cdqA-4ri0A:
22.31
5cdqC-4ri0A:
22.31
5cdqD-4ri0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.87A 5ec8A-4ri0A:
undetectable		 5ec8A-4ri0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.96A 5vimA-4ri0A:
undetectable		 5vimA-4ri0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.96A 5vimB-4ri0A:
undetectable		 5vimB-4ri0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens) 		5 / 12 GLY A 318
GLY A 177
GLY A 306
VAL A 207
ILE A 186
 None
 0.94A 5wz2C-4ri0A:
undetectable		 5wz2C-4ri0A:
21.26