SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ri6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		5 / 12 GLY A 115
VAL A 118
VAL A 143
LEU A 176
LEU A 140
 None
 1.09A 1mx1E-4ri6A:
undetectable		 1mx1E-4ri6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 SER A 114
GLY A 115
ARG A  18
 None
 0.56A 1t9wA-4ri6A:
undetectable		 1t9wA-4ri6A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 SER A 114
GLY A 115
ARG A  70
 None
None
GSH  A 500 ( 4.5A)
 0.49A 1t9wA-4ri6A:
undetectable		 1t9wA-4ri6A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 ARG A  18
GLY A 111
PRO A 112
 None
 0.75A 2hreD-4ri6A:
undetectable		 2hreD-4ri6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 6 ASP A 181
VAL A 137
ILE A 133
TYR A 184
 None
 1.11A 2yfbB-4ri6A:
2.2		 2yfbB-4ri6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		5 / 12 GLY A 111
ILE A 133
LEU A 132
LEU A 185
LEU A 176
 None
 1.34A 3cs8A-4ri6A:
undetectable		 3cs8A-4ri6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 LEU A 170
ARG A 155
ASN A 193
 None
 0.48A 3qxvD-4ri6A:
undetectable		 3qxvD-4ri6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 6 ARG A  18
PRO A  57
GLU A  68
SER A  69
 None
GSH  A 500 (-4.5A)
GSH  A 500 (-2.3A)
GSH  A 500 (-2.6A)
 0.94A 3vlnA-4ri6A:
21.1		 3vlnA-4ri6A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 6 TRP A 195
ASN A 172
TYR A 147
LEU A 144
 None
 1.43A 4f8yA-4ri6A:
undetectable
4f8yB-4ri6A:
undetectable		 4f8yA-4ri6A:
22.81
4f8yB-4ri6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		5 / 12 LEU A 144
PHE A 186
TYR A 184
GLY A 115
LEU A 117
 None
 1.31A 4j7xB-4ri6A:
undetectable		 4j7xB-4ri6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 5 LEU A 167
ARG A  74
PRO A  57
SER A  13
 None
None
GSH  A 500 (-4.5A)
GSH  A 500 ( 2.2A)
 1.45A 4kmmB-4ri6A:
undetectable		 4kmmB-4ri6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 ASP A 106
TRP A 196
SER A 114
 None
 1.02A 4lrhB-4ri6A:
undetectable		 4lrhB-4ri6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 ASP A 106
TRP A 196
SER A 114
 None
 1.04A 4lrhF-4ri6A:
undetectable		 4lrhF-4ri6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		5 / 12 VAL A 128
ASP A 129
GLU A 130
LEU A 122
LEU A 176
 None
 1.21A 5hnxB-4ri6A:
undetectable		 5hnxB-4ri6A:
18.97