SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ric'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 10 SER A 918
SER A 839
PHE A 951
LEU A 870
PHE A 851
 None
 1.48A 1q23K-4ricA:
undetectable		 1q23K-4ricA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 8 LEU A 916
GLY A 843
LEU A 870
PRO A 585
 None
 0.89A 1ya4A-4ricA:
2.6		 1ya4A-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 4 LEU A 571
PRO A 541
ILE A 548
LEU A 549
 None
 1.08A 1ya4B-4ricA:
2.5		 1ya4B-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 12 GLN A 533
LEU A 421
LEU A 434
ALA A 440
ILE A 439
 None
 1.00A 2bxcA-4ricA:
undetectable		 2bxcA-4ricA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 11 TYR A 436
VAL A 446
ILE A 447
LEU A 443
ILE A 537
 None
 1.12A 2dg9A-4ricA:
undetectable		 2dg9A-4ricA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 12 PRO A 701
THR A 667
GLY A 663
THR A 661
LEU A 655
 None
 1.14A 2uvnA-4ricA:
undetectable		 2uvnA-4ricA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 8 ARG A 739
HIS A 946
ARG A 945
THR A 877
 None
 1.42A 2vxaF-4ricA:
undetectable
2vxaG-4ricA:
undetectable
2vxaI-4ricA:
undetectable		 2vxaF-4ricA:
9.21
2vxaG-4ricA:
9.21
2vxaI-4ricA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 12 LEU A 935
LEU A 973
ILE A 831
PHE A 922
PHE A 838
 None
 0.96A 2weyA-4ricA:
2.9		 2weyA-4ricA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		3 / 3 PRO A 867
LEU A 868
GLN A 864
 None
 0.44A 3hznG-4ricA:
undetectable
3hznH-4ricA:
undetectable		 3hznG-4ricA:
17.52
3hznH-4ricA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 12 LEU A 845
VAL A 943
GLY A 942
PHE A 838
LEU A 841
 None
 1.37A 3medA-4ricA:
undetectable
3medB-4ricA:
undetectable		 3medA-4ricA:
22.52
3medB-4ricA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 6 LEU A 417
TYR A 418
ARG A 420
LEU A 450
 None
 1.07A 3rd0A-4ricA:
2.6		 3rd0A-4ricA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 7 GLU A 438
TYR A 436
GLU A 435
ARG A 420
 None
 1.08A 4mi4B-4ricA:
undetectable
4mi4C-4ricA:
undetectable		 4mi4B-4ricA:
16.50
4mi4C-4ricA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 8 GLU A 438
TYR A 436
GLU A 435
ARG A 420
 None
 1.08A 4mj8B-4ricA:
undetectable
4mj8C-4ricA:
undetectable		 4mj8B-4ricA:
15.57
4mj8C-4ricA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		4 / 6 ASP A 560
VAL A 574
ALA A 865
PHE A 866
 None
 1.09A 4nedA-4ricA:
undetectable		 4nedA-4ricA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		3 / 3 GLN A 568
SER A 617
ASP A 614
 None
 0.95A 4qwpA-4ricA:
undetectable
4qwpB-4ricA:
undetectable		 4qwpA-4ricA:
16.77
4qwpB-4ricA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		5 / 12 VAL A 674
LEU A 711
LEU A 715
VAL A 687
GLN A 678
 None
 1.13A 5im2A-4ricA:
undetectable		 5im2A-4ricA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		3 / 3 GLY A 741
LEU A 744
HIS A 985
 None
 0.55A 5u63A-4ricA:
undetectable		 5u63A-4ricA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens) 		3 / 3 GLY A 741
LEU A 744
HIS A 985
 None
 0.52A 5u63B-4ricA:
undetectable		 5u63B-4ricA:
17.16