SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		3 / 3 TRP A 267
VAL A 268
PRO A 269
 3R2  A 401 (-3.5A)
3R2  A 401 (-4.6A)
None
 0.73A 1rg1A-4rihA:
undetectable		 1rg1A-4rihA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		3 / 3 TRP A 267
VAL A 268
PRO A 269
 3R2  A 401 (-3.5A)
3R2  A 401 (-4.6A)
None
 0.74A 1rh0A-4rihA:
undetectable		 1rh0A-4rihA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		4 / 5 TRP A 191
PRO A  19
LEU A  17
GLY A 114
 None
 1.28A 1ya4C-4rihA:
undetectable		 1ya4C-4rihA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		5 / 12 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.37A 2y6rC-4rihA:
3.1		 2y6rC-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 10 ILE A   3
MET A  91
ALA A  98
LEU A  99
ALA A 119
 None
 1.32A 3lw5B-4rihA:
undetectable		 3lw5B-4rihA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 VAL A 287
PHE A 170
GLY A 114
GLY A 113
TYR A 131
 3R2  A 401 (-3.6A)
None
None
None
None
 1.23A 3owxA-4rihA:
4.8
3owxB-4rihA:
4.9		 3owxA-4rihA:
21.23
3owxB-4rihA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 9 LYS A 225
LEU A 221
THR A 227
ALA A 224
THR A 248
 None
 1.45A 3ozkA-4rihA:
undetectable		 3ozkA-4rihA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		4 / 8 VAL A 280
HIS A 282
PRO A 193
TRP A 191
 None
 1.30A 3v35A-4rihA:
undetectable		 3v35A-4rihA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.42A 3v3nA-4rihA:
2.9		 3v3nA-4rihA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.41A 3v3nD-4rihA:
3.0		 3v3nD-4rihA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.31A 4a6nB-4rihA:
3.1		 4a6nB-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 10 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.37A 4a99A-4rihA:
3.0		 4a99A-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.37A 4a99B-4rihA:
2.8		 4a99B-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.36A 4a99C-4rihA:
3.0		 4a99C-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 11 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.37A 4a99D-4rihA:
3.1		 4a99D-4rihA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		4 / 6 ARG A 179
LEU A 359
MET A 188
ASP A 172
 None
 1.30A 4cevA-4rihA:
undetectable
4cevB-4rihA:
undetectable		 4cevA-4rihA:
26.74
4cevB-4rihA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		4 / 6 ARG A 179
LEU A 359
MET A 188
ASP A 172
 None
 1.32A 4cevE-4rihA:
undetectable
4cevF-4rihA:
undetectable		 4cevE-4rihA:
26.74
4cevF-4rihA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 7 LYS A 225
LEU A 221
THR A 227
ALA A 224
THR A 248
 None
 1.43A 4ik7A-4rihA:
undetectable		 4ik7A-4rihA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		5 / 12 GLY A 285
GLY A 286
THR A 138
PHE A 229
ILE A 301
 3R2  A 401 (-3.3A)
3R2  A 401 (-3.4A)
None
None
None
 1.02A 4pghD-4rihA:
2.9		 4pghD-4rihA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 12 HIS A 283
GLN A 299
ALA A 292
LEU A 270
GLY A 218
 3R2  A 401 (-4.3A)
None
None
3R2  A 401 (-3.7A)
3R2  A 401 (-3.5A)
 1.26A 4qckA-4rihA:
undetectable		 4qckA-4rihA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		4 / 6 GLU A  80
GLY A 305
PHE A 223
ARG A 220
 None
None
None
3R2  A 401 (-3.7A)
 1.41A 5jcnB-4rihA:
2.7		 5jcnB-4rihA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		5 / 10 ILE A 173
PHE A 170
GLY A 114
GLY A 113
TYR A 131
 None
 1.26A 5lbtA-4rihA:
4.8
5lbtB-4rihA:
4.8		 5lbtA-4rihA:
21.03
5lbtB-4rihA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		3 / 3 ARG A  66
PHE A  88
LEU A 152
 None
 0.75A 5x1bC-4rihA:
undetectable		 5x1bC-4rihA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		3 / 3 ASP A 137
PHE A  88
ARG A 220
 3R2  A 401 (-3.6A)
None
3R2  A 401 (-3.7A)
 0.94A 5yw0A-4rihA:
undetectable		 5yw0A-4rihA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		4 / 7 VAL A 373
PRO A 362
LEU A 361
LEU A  20
 None
 0.90A 6aycA-4rihA:
undetectable		 6aycA-4rihA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE
(Streptomyces
fradiae;
Streptomyces
cyanogenus) 		4 / 6 VAL A 268
TRP A 267
ALA A 247
THR A 216
 3R2  A 401 (-4.6A)
3R2  A 401 (-3.5A)
3R2  A 401 (-3.5A)
3R2  A 401 ( 4.8A)
 1.04A 6cduB-4rihA:
undetectable
6cduC-4rihA:
undetectable		 6cduB-4rihA:
24.32
6cduC-4rihA:
24.32