SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ALA B 382
VAL B 453
TRP B 305
 None
 0.73A 1grmA-4ritB:
undetectable		 1grmA-4ritB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ALA B 382
VAL B 453
TRP B 305
 None
 0.73A 1grmB-4ritB:
undetectable		 1grmB-4ritB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ALA B 382
VAL B 453
TRP B 305
 None
 0.88A 1jo4A-4ritB:
undetectable		 1jo4A-4ritB:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ALA B 382
VAL B 453
TRP B 305
 None
 0.88A 1jo4B-4ritB:
undetectable		 1jo4B-4ritB:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 11 LEU B 125
LEU B 359
ALA B 278
VAL B 356
LEU B 130
 GOL  B 505 ( 4.2A)
None
None
None
None
 1.44A 1kt6A-4ritB:
undetectable		 1kt6A-4ritB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 11 LEU B 125
LEU B 359
ALA B 278
VAL B 356
LEU B 130
 GOL  B 505 ( 4.2A)
None
None
None
None
 1.38A 1kt7A-4ritB:
undetectable		 1kt7A-4ritB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 PHE B 300
TYR B 371
TYR B 307
 None
None
LLP  B 304 ( 4.8A)
 1.04A 1x70B-4ritB:
undetectable		 1x70B-4ritB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		4 / 7 GLY B 410
PHE B 394
PRO B 393
ASP B 413
 None
 1.18A 2aouB-4ritB:
undetectable		 2aouB-4ritB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		4 / 5 GLY B 410
TRP B 449
ARG B 409
LEU B 450
 None
None
GOL  B 506 (-3.0A)
None
 1.27A 2j2pD-4ritB:
undetectable
2j2pF-4ritB:
undetectable		 2j2pD-4ritB:
19.09
2j2pF-4ritB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ARG B 284
ARG B 380
ARG B 373
 None
 1.20A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ARG B 373
ARG B 284
ARG B 380
 None
 1.18A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 ARG B 380
ARG B 373
ARG B 284
 None
 1.17A 2jb7A-4ritB:
undetectable
2jb7B-4ritB:
0.3
2jb7C-4ritB:
0.2		 2jb7A-4ritB:
18.01
2jb7B-4ritB:
18.01
2jb7C-4ritB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 10 ALA B 278
LEU B 363
LEU B 136
ILE B 133
ALA B 132
 None
 1.15A 3r9cA-4ritB:
undetectable		 3r9cA-4ritB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA B 274
ASN B 301
ILE B 292
VAL B 271
HIS B 270
 LLP  B 304 ( 3.5A)
LLP  B 304 ( 3.7A)
None
None
None
 1.26A 4azsA-4ritB:
2.9		 4azsA-4ritB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 LYS B  36
LEU B  32
ALA B  35
 None
 0.76A 4iizA-4ritB:
undetectable		 4iizA-4ritB:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		4 / 6 GLU B 283
ARG B 284
ASP B 376
ARG B 373
 None
 1.39A 4kcnA-4ritB:
undetectable		 4kcnA-4ritB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 LEU B 153
ARG B 352
MET B 118
 None
 0.93A 4m11C-4ritB:
undetectable		 4m11C-4ritB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		4 / 6 ILE B 437
PHE B 438
ILE B 405
ILE B 464
 None
 0.77A 4o8fB-4ritB:
undetectable		 4o8fB-4ritB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 11 GLY B 245
ALA B 244
ASP B 272
ILE B 292
ILE B 298
 None
None
LLP  B 304 ( 2.7A)
None
None
 0.79A 4q1xA-4ritB:
undetectable		 4q1xA-4ritB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 PRO B  45
MET B  46
TYR B  87
 None
 1.13A 4qa0B-4ritB:
3.1		 4qa0B-4ritB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		4 / 6 ILE B  72
ALA B  71
THR B  67
ALA B  63
 None
 0.79A 4zf8A-4ritB:
undetectable		 4zf8A-4ritB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 8 ALA B 189
THR B 246
THR B 249
ALA B 214
TRP B 449
 None
 1.48A 5x2tI-4ritB:
undetectable
5x2tJ-4ritB:
undetectable
5x2tK-4ritB:
undetectable
5x2tL-4ritB:
undetectable		 5x2tI-4ritB:
16.78
5x2tJ-4ritB:
14.72
5x2tK-4ritB:
16.78
5x2tL-4ritB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 12 ILE B 133
LEU B 279
LEU B 130
PHE B 137
THR B 148
 None
 1.03A 6b52A-4ritB:
undetectable		 6b52A-4ritB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 12 ILE B 133
LEU B 279
PHE B 137
LEU B 147
THR B 148
 None
 1.20A 6b52A-4ritB:
undetectable		 6b52A-4ritB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 11 SER B 186
ALA B 189
THR B 246
THR B 249
ALA B 398
 None
 1.25A 6efnA-4ritB:
undetectable		 6efnA-4ritB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 9 GLY B 378
LEU B 454
GLY B 276
TYR B 275
ARG B 284
 GOL  B 504 (-3.1A)
GOL  B 504 (-4.8A)
None
LLP  B 304 ( 4.8A)
None
 1.31A 6nm4B-4ritB:
undetectable		 6nm4B-4ritB:
18.61