SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		3 / 3 TRP A 204
VAL A 221
TRP A 227
 None
 0.99A 1c4dC-4rjzA:
undetectable
1c4dD-4rjzA:
undetectable		 1c4dC-4rjzA:
5.73
1c4dD-4rjzA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 LEU A 158
LEU A 177
ALA A 173
LEU A 170
THR A 281
 None
 1.16A 1crbA-4rjzA:
undetectable		 1crbA-4rjzA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 LEU A 283
SER A 188
ILE A 187
LEU A 170
THR A 356
 None
 1.20A 1ddsB-4rjzA:
undetectable		 1ddsB-4rjzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 4 VAL A 128
TRP A 301
ALA A 302
VAL A 137
 None
 1.38A 1gmkC-4rjzA:
undetectable
1gmkD-4rjzA:
undetectable		 1gmkC-4rjzA:
5.73
1gmkD-4rjzA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 11 PHE A  96
ILE A  86
GLY A 136
PHE A 102
TYR A 120
 None
 1.28A 1hvyC-4rjzA:
undetectable		 1hvyC-4rjzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 9 PHE A  96
ILE A  86
GLY A 136
PHE A 102
TYR A 120
 None
 1.41A 1i00A-4rjzA:
undetectable		 1i00A-4rjzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 8 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.72A 1rtsA-4rjzA:
undetectable		 1rtsA-4rjzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.74A 1rtsB-4rjzA:
undetectable		 1rtsB-4rjzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 5 PRO A 164
LEU A 158
GLY A 157
LYS A 176
 None
 1.31A 1ya4C-4rjzA:
undetectable		 1ya4C-4rjzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 5 TRP A 167
PRO A 286
GLY A 219
GLY A 209
 None
 1.00A 1zlqA-4rjzA:
undetectable		 1zlqA-4rjzA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 11 GLY A 410
ILE A 215
GLY A 368
ALA A 379
ILE A 405
 None
 1.02A 2b60B-4rjzA:
undetectable		 2b60B-4rjzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.74A 2tsrA-4rjzA:
undetectable		 2tsrA-4rjzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 10 PHE A  96
ILE A  86
GLY A 136
PHE A 102
TYR A 120
 None
 1.37A 2tsrC-4rjzA:
undetectable		 2tsrC-4rjzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 PHE A 252
TYR A 148
ALA A 254
LEU A 349
MET A 270
 None
 1.27A 2x2nB-4rjzA:
undetectable		 2x2nB-4rjzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 5 GLN A 333
PHE A 328
LEU A 361
PHE A 121
 None
 1.47A 3ablC-4rjzA:
undetectable
3ablJ-4rjzA:
undetectable		 3ablC-4rjzA:
20.57
3ablJ-4rjzA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 TRP A 204
PHE A 189
THR A 198
LEU A 230
THR A 226
 None
 1.34A 3elzA-4rjzA:
undetectable		 3elzA-4rjzA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 PRO A 203
ARG A 367
GLY A 368
PRO A 369
 None
 0.94A 3ucbB-4rjzA:
undetectable		 3ucbB-4rjzA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ALA A  87
ILE A  88
HIS A  93
GLY A 136
 None
 0.92A 3v4tH-4rjzA:
undetectable		 3v4tH-4rjzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 10 PHE A  96
ILE A  86
GLY A 136
PHE A 102
TYR A 120
 None
 1.34A 4eb4D-4rjzA:
undetectable		 4eb4D-4rjzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 11 ILE A  85
ALA A 313
GLU A 318
GLY A  56
ASN A  55
 None
 1.26A 4j83A-4rjzA:
undetectable		 4j83A-4rjzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 9 THR A 226
LEU A 230
GLN A 245
PHE A 189
LEU A 388
 None
 1.45A 4ltwA-4rjzA:
undetectable		 4ltwA-4rjzA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 GLU A 233
ARG A 175
ALA A 173
GLY A 186
LEU A 177
 None
 1.09A 4oaeA-4rjzA:
undetectable		 4oaeA-4rjzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 GLY A 297
ASN A  90
HIS A  93
LYS A 139
ILE A  88
 None
 1.19A 4ypaC-4rjzA:
undetectable		 4ypaC-4rjzA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 9 ILE A 267
GLY A 263
THR A 143
LEU A 334
LEU A 361
 None
 1.41A 5fhzB-4rjzA:
undetectable		 5fhzB-4rjzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.79A 5h3aA-4rjzA:
undetectable		 5h3aA-4rjzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 PHE A  96
ILE A  86
GLY A 136
TYR A 120
 None
 0.91A 5h3aA-4rjzA:
undetectable		 5h3aA-4rjzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.82A 5h3aB-4rjzA:
undetectable		 5h3aB-4rjzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		3 / 3 THR A 198
SER A 377
ASP A  89
 None
 0.85A 5kvaA-4rjzA:
undetectable		 5kvaA-4rjzA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.78A 5nooA-4rjzA:
undetectable		 5nooA-4rjzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.77A 5x5qC-4rjzA:
undetectable		 5x5qC-4rjzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 7 PHE A  96
ILE A  86
GLY A 136
TYR A 120
 None
 0.90A 5x5qC-4rjzA:
undetectable		 5x5qC-4rjzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 8 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.75A 5x5qD-4rjzA:
undetectable		 5x5qD-4rjzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 8 ILE A  88
GLY A 136
PHE A 102
TYR A 120
 None
 0.75A 5x5qF-4rjzA:
undetectable		 5x5qF-4rjzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 10 PHE A  96
ILE A  86
GLY A 136
PHE A 102
TYR A 120
 None
 1.34A 5x66D-4rjzA:
undetectable		 5x66D-4rjzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 4 ALA A 205
ALA A 210
ALA A 220
ALA A 223
 None
 0.78A 6gtqA-4rjzA:
undetectable
6gtqB-4rjzA:
undetectable		 6gtqA-4rjzA:
19.75
6gtqB-4rjzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		4 / 4 ALA A 220
ALA A 223
ALA A 205
ALA A 210
 None
 0.78A 6gtqA-4rjzA:
undetectable
6gtqB-4rjzA:
undetectable		 6gtqA-4rjzA:
19.75
6gtqB-4rjzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)
(Agrobacterium
fabrum) 		5 / 12 GLY A 297
ASN A  90
HIS A  93
LYS A 139
ILE A  88
 None
 1.23A 6ineA-4rjzA:
undetectable		 6ineA-4rjzA:
18.25