SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		5 / 12 GLY A 208
SER A 331
ILE A 266
GLY A 243
ILE A 244
 None
 1.08A 1q8jB-4rk0A:
undetectable		 1q8jB-4rk0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		5 / 12 LEU A 305
LEU A 306
ILE A  91
GLY A 299
LEU A 298
 None
 1.21A 2yjaB-4rk0A:
undetectable		 2yjaB-4rk0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		4 / 5 PRO A  82
VAL A 278
THR A 222
GLY A 229
 None
 1.09A 3elzB-4rk0A:
undetectable		 3elzB-4rk0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		3 / 3 GLN A 300
THR A 301
THR A 304
 None
 0.80A 4fu9A-4rk0A:
undetectable		 4fu9A-4rk0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		3 / 3 GLN A 300
THR A 301
THR A 304
 None
 0.79A 4fufA-4rk0A:
undetectable		 4fufA-4rk0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		4 / 8 ASN A  81
LEU A 224
ASN A 248
ILE A 247
 RIB  A 401 (-3.3A)
None
RIB  A 401 (-3.8A)
None
 0.89A 4k0bA-4rk0A:
undetectable		 4k0bA-4rk0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		4 / 8 ASN A  81
LEU A 224
ASN A 248
ILE A 247
 RIB  A 401 (-3.3A)
None
RIB  A 401 (-3.8A)
None
 0.94A 4l7iA-4rk0A:
undetectable		 4l7iA-4rk0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		5 / 12 LEU A 224
LEU A 255
ALA A 246
VAL A 193
GLY A 228
 None
 1.02A 4rn6B-4rk0A:
undetectable		 4rn6B-4rk0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		5 / 11 LEU A 305
LEU A 306
ILE A  91
GLY A 299
LEU A 298
 None
 1.19A 5dxbB-4rk0A:
undetectable		 5dxbB-4rk0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		4 / 6 ILE A  72
ALA A 303
LEU A 306
ILE A 153
 None
 0.84A 5mvmB-4rk0A:
undetectable
5mvmC-4rk0A:
undetectable		 5mvmB-4rk0A:
16.67
5mvmC-4rk0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4rk0 LACI FAMILY
SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecalis) 		3 / 3 THR A 140
THR A 144
ARG A 123
 None
 1.07A 5wm2A-4rk0A:
undetectable		 5wm2A-4rk0A:
20.43