SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 ILE A 281
ILE A 275
LEU A 291
ILE A 287
ILE A 269
 None
None
None
CL  A 402 ( 4.4A)
None
 1.06A 1oipA-4rk1A:
undetectable		 1oipA-4rk1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 250
ILE A 281
ILE A 275
LEU A 291
ILE A 269
 None
 0.92A 1oipA-4rk1A:
undetectable		 1oipA-4rk1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 258
SER A 242
ILE A 221
ALA A 244
TYR A 273
 None
 1.26A 2japB-4rk1A:
7.5		 2japB-4rk1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 258
SER A 242
ILE A 221
ALA A 244
TYR A 273
 None
 1.26A 2japC-4rk1A:
7.4		 2japC-4rk1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 258
SER A 242
ILE A 221
ALA A 244
TYR A 273
 None
 1.28A 2japD-4rk1A:
7.3		 2japD-4rk1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 8 ILE A 203
PHE A 248
LEU A 250
GLY A 172
 None
 0.83A 2vdbA-4rk1A:
undetectable		 2vdbA-4rk1A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 8 GLY A 257
ILE A 281
MET A 283
CYH A 284
 None
 0.94A 3ko0O-4rk1A:
undetectable
3ko0Q-4rk1A:
undetectable		 3ko0O-4rk1A:
16.43
3ko0Q-4rk1A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		3 / 3 ASP A  75
ASN A 103
SER A 228
 None
 0.93A 3lslA-4rk1A:
3.0
3lslD-4rk1A:
2.9		 3lslA-4rk1A:
24.29
3lslD-4rk1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		3 / 3 SER A 228
ASP A  75
ASN A 103
 None
 0.95A 3lslA-4rk1A:
3.0
3lslD-4rk1A:
2.9		 3lslA-4rk1A:
24.29
3lslD-4rk1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 8 PHE A  80
GLN A 296
ARG A 165
ASP A 168
 RIB  A 401 (-3.6A)
RIB  A 401 (-3.4A)
None
None
 1.18A 3mjrD-4rk1A:
undetectable		 3mjrD-4rk1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 250
PHE A 227
PHE A  80
GLY A 171
ASP A 279
 None
RIB  A 401 (-4.6A)
RIB  A 401 (-3.6A)
None
RIB  A 401 (-2.7A)
 1.29A 3tbgC-4rk1A:
undetectable		 3tbgC-4rk1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 PHE A 248
GLY A 172
GLY A 176
ALA A 209
GLY A 205
 None
 1.15A 3tegA-4rk1A:
undetectable		 3tegA-4rk1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 8 THR A 119
ARG A 121
GLY A  70
PHE A 126
 None
 0.94A 3tzfB-4rk1A:
undetectable		 3tzfB-4rk1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 7 ARG A 170
GLY A 277
ILE A 276
VAL A 327
 None
 0.71A 3ufnB-4rk1A:
undetectable		 3ufnB-4rk1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		3 / 3 THR A 135
ASN A 139
GLU A 158
 None
 0.76A 3v4tA-4rk1A:
undetectable
3v4tC-4rk1A:
undetectable		 3v4tA-4rk1A:
21.57
3v4tC-4rk1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 308
LEU A 309
ILE A  88
GLY A 302
LEU A 301
 None
 1.14A 5gtrA-4rk1A:
undetectable		 5gtrA-4rk1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 8 HIS A 178
HIS A 184
GLY A 246
SER A 274
 None
 0.88A 5m8rC-4rk1A:
undetectable		 5m8rC-4rk1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 6 ILE A  69
ALA A 306
LEU A 309
ILE A 150
 None
 0.84A 5mvmB-4rk1A:
undetectable
5mvmC-4rk1A:
undetectable		 5mvmB-4rk1A:
11.96
5mvmC-4rk1A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		4 / 4 LEU A 179
LEU A 182
SER A 334
ALA A 336
 None
 1.06A 5uunA-4rk1A:
undetectable		 5uunA-4rk1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 10 LEU A 262
LEU A 223
LEU A 250
ALA A 249
GLU A 263
 None
 1.26A 5y7pG-4rk1A:
undetectable		 5y7pG-4rk1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR
(Enterococcus
faecium) 		5 / 12 LEU A 258
LEU A 239
ALA A 244
GLY A 176
LEU A 179
 None
 1.03A 6b0iB-4rk1A:
3.6		 6b0iB-4rk1A:
18.82