SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1c9sB-4rk2A:
undetectable
1c9sC-4rk2A:
undetectable		 1c9sB-4rk2A:
11.03
1c9sC-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.20A 1c9sC-4rk2A:
undetectable
1c9sD-4rk2A:
undetectable		 1c9sC-4rk2A:
11.03
1c9sD-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 6 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.16A 1errB-4rk2A:
undetectable		 1errB-4rk2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 LEU A 215
PRO A 206
SER A 201
VAL A 203
MET A 416
 None
 1.46A 1fdwA-4rk2A:
undetectable		 1fdwA-4rk2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1gtfA-4rk2A:
undetectable
1gtfK-4rk2A:
undetectable		 1gtfA-4rk2A:
11.03
1gtfK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 1gtfA-4rk2A:
undetectable
1gtfB-4rk2A:
undetectable		 1gtfA-4rk2A:
11.03
1gtfB-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.21A 1gtfB-4rk2A:
undetectable
1gtfC-4rk2A:
undetectable		 1gtfB-4rk2A:
11.03
1gtfC-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1gtfC-4rk2A:
undetectable
1gtfD-4rk2A:
undetectable		 1gtfC-4rk2A:
11.03
1gtfD-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 1gtfH-4rk2A:
undetectable
1gtfI-4rk2A:
undetectable		 1gtfH-4rk2A:
11.03
1gtfI-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1gtfI-4rk2A:
undetectable
1gtfJ-4rk2A:
undetectable		 1gtfI-4rk2A:
11.03
1gtfJ-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 ASP A 405
SER A 408
ASP A 400
GLN A 234
 None
 1.40A 1n2xB-4rk2A:
undetectable		 1n2xB-4rk2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 142
LEU A 311
GLY A 310
THR A 134
ILE A 130
 None
 1.49A 1p93A-4rk2A:
undetectable		 1p93A-4rk2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1utdD-4rk2A:
undetectable
1utdE-4rk2A:
undetectable		 1utdD-4rk2A:
11.03
1utdE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.23A 1utdA-4rk2A:
undetectable
1utdK-4rk2A:
undetectable		 1utdA-4rk2A:
11.03
1utdK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 LEU A  51
PHE A  64
LEU A  39
LEU A 311
ILE A  91
 None
 1.10A 1yi4A-4rk2A:
undetectable		 1yi4A-4rk2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 373
ILE A 357
PHE A 345
GLY A 267
PHE A 363
 None
 1.20A 1zz1B-4rk2A:
undetectable
1zz1C-4rk2A:
undetectable		 1zz1B-4rk2A:
22.04
1zz1C-4rk2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 TRP A  37
THR A  45
TYR A  47
 None
 0.89A 2a3aA-4rk2A:
undetectable		 2a3aA-4rk2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 TRP A  37
THR A  45
TYR A  47
 None
 0.89A 2a3aB-4rk2A:
undetectable		 2a3aB-4rk2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 TRP A  37
THR A  45
TYR A  47
 None
 0.90A 2a3bA-4rk2A:
undetectable		 2a3bA-4rk2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 ALA A 398
TYR A 227
VAL A 203
GLY A 412
ILE A 402
 None
 1.41A 2dcfA-4rk2A:
undetectable		 2dcfA-4rk2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.15A 2jfaA-4rk2A:
undetectable		 2jfaA-4rk2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 ALA A 194
GLY A 262
GLY A 259
THR A 178
PRO A 265
 None
 1.07A 2okcA-4rk2A:
undetectable		 2okcA-4rk2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.17A 2qxsA-4rk2A:
undetectable		 2qxsA-4rk2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.17A 2qxsB-4rk2A:
undetectable		 2qxsB-4rk2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.18A 2zj0A-4rk2A:
undetectable		 2zj0A-4rk2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 7 VAL A 203
ASP A 176
LEU A 196
ILE A 402
 None
 1.01A 3avpA-4rk2A:
undetectable		 3avpA-4rk2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.15A 3ce6A-4rk2A:
undetectable		 3ce6A-4rk2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.18A 3ce6C-4rk2A:
undetectable		 3ce6C-4rk2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.19A 3ce6D-4rk2A:
undetectable		 3ce6D-4rk2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 TYR A 153
ALA A 161
ALA A 194
TYR A 192
 None
 1.27A 3d91A-4rk2A:
undetectable		 3d91A-4rk2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 SER A 280
PHE A 257
LYS A 284
 None
 0.89A 3u88A-4rk2A:
undetectable		 3u88A-4rk2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 6 GLY A 302
PRO A 375
GLY A 127
GLU A 132
 None
 0.87A 4dxuA-4rk2A:
6.0		 4dxuA-4rk2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 HIS A 399
ALA A 398
GLN A 204
TYR A 227
 None
 1.29A 4gboA-4rk2A:
undetectable		 4gboA-4rk2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 11 ILE A  94
ILE A 109
LEU A  82
ALA A 106
ILE A 135
 None
 1.09A 4h1nA-4rk2A:
undetectable		 4h1nA-4rk2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.26A 4lvcA-4rk2A:
undetectable		 4lvcA-4rk2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.29A 4lvcC-4rk2A:
undetectable		 4lvcC-4rk2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 VAL A 339
ALA A 340
GLY A 310
PHE A 144
SER A 146
 None
 1.26A 4mm5A-4rk2A:
undetectable		 4mm5A-4rk2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 VAL A 339
ALA A 340
GLY A 310
PHE A 144
SER A 146
 None
 1.28A 4mmeA-4rk2A:
undetectable		 4mmeA-4rk2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 223
GLN A 204
VAL A 394
THR A 407
MET A 403
 None
 1.29A 4ojbA-4rk2A:
undetectable		 4ojbA-4rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 12 LEU A 413
LEU A 223
GLN A 204
VAL A 394
THR A 407
MET A 403
 None
 1.50A 4oktA-4rk2A:
undetectable		 4oktA-4rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 223
GLN A 204
VAL A 394
THR A 407
MET A 403
 None
 1.31A 4okxA-4rk2A:
undetectable		 4okxA-4rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 LEU A 324
ASN A 314
VAL A  92
LEU A  82
LEU A 103
 None
 1.04A 4po0A-4rk2A:
2.3		 4po0A-4rk2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 ASP A  90
HIS A 319
LYS A 320
 None
 0.78A 4qzuD-4rk2A:
undetectable		 4qzuD-4rk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 11 SER A 354
LEU A 348
ALA A 347
THR A 268
ILE A 150
 None
 1.32A 4uuuB-4rk2A:
undetectable		 4uuuB-4rk2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eeuA-4rk2A:
undetectable
5eeuB-4rk2A:
undetectable		 5eeuA-4rk2A:
11.03
5eeuB-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eeuD-4rk2A:
undetectable
5eeuE-4rk2A:
undetectable		 5eeuD-4rk2A:
11.03
5eeuE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eeuJ-4rk2A:
undetectable
5eeuK-4rk2A:
undetectable		 5eeuJ-4rk2A:
11.03
5eeuK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eevD-4rk2A:
undetectable
5eevE-4rk2A:
undetectable		 5eevD-4rk2A:
11.03
5eevE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eevJ-4rk2A:
undetectable
5eevK-4rk2A:
undetectable		 5eevJ-4rk2A:
11.03
5eevK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eewD-4rk2A:
undetectable
5eewE-4rk2A:
undetectable		 5eewD-4rk2A:
11.03
5eewE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eewJ-4rk2A:
undetectable
5eewK-4rk2A:
undetectable		 5eewJ-4rk2A:
11.03
5eewK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eexD-4rk2A:
undetectable
5eexE-4rk2A:
undetectable		 5eexD-4rk2A:
11.03
5eexE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eexJ-4rk2A:
undetectable
5eexK-4rk2A:
undetectable		 5eexJ-4rk2A:
11.03
5eexK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eeyD-4rk2A:
undetectable
5eeyE-4rk2A:
undetectable		 5eeyD-4rk2A:
11.03
5eeyE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eeyJ-4rk2A:
undetectable
5eeyK-4rk2A:
undetectable		 5eeyJ-4rk2A:
11.03
5eeyK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5eezD-4rk2A:
undetectable
5eezE-4rk2A:
undetectable		 5eezD-4rk2A:
11.03
5eezE-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5eezJ-4rk2A:
undetectable
5eezK-4rk2A:
undetectable		 5eezJ-4rk2A:
11.03
5eezK-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5ef0D-4rk2A:
undetectable
5ef0E-4rk2A:
undetectable		 5ef0D-4rk2A:
11.03
5ef0E-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5ef0J-4rk2A:
undetectable
5ef0K-4rk2A:
undetectable		 5ef0J-4rk2A:
11.03
5ef0K-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5ef1D-4rk2A:
undetectable
5ef1E-4rk2A:
undetectable		 5ef1D-4rk2A:
11.03
5ef1E-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5ef1J-4rk2A:
undetectable
5ef1K-4rk2A:
undetectable		 5ef1J-4rk2A:
11.03
5ef1K-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5ef2D-4rk2A:
undetectable
5ef2E-4rk2A:
undetectable		 5ef2D-4rk2A:
11.03
5ef2E-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5ef2J-4rk2A:
undetectable
5ef2K-4rk2A:
undetectable		 5ef2J-4rk2A:
11.03
5ef2K-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.22A 5ef3D-4rk2A:
undetectable
5ef3E-4rk2A:
undetectable		 5ef3D-4rk2A:
11.03
5ef3E-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 207
ALA A 305
THR A 303
HIS A 295
ILE A 208
 None
 1.24A 5ef3J-4rk2A:
undetectable
5ef3K-4rk2A:
undetectable		 5ef3J-4rk2A:
11.03
5ef3K-4rk2A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 HIS A 399
ALA A 398
GLN A 204
TYR A 227
 None
 1.29A 5uizA-4rk2A:
undetectable		 5uizA-4rk2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 4 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.30A 6f3nB-4rk2A:
undetectable		 6f3nB-4rk2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.31A 6gbnA-4rk2A:
undetectable		 6gbnA-4rk2A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 5 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.30A 6gbnD-4rk2A:
undetectable		 6gbnD-4rk2A:
23.35