SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 9 THR A  86
LEU A  93
VAL A  65
ILE A  78
ILE A 143
 None
 1.37A 1gebA-4rk6A:
undetectable		 1gebA-4rk6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		4 / 7 VAL A 108
LEU A  98
LEU A 123
ALA A  75
 None
 0.76A 1j8uA-4rk6A:
undetectable		 1j8uA-4rk6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 GLY A 251
VAL A 182
LEU A 181
ALA A 180
THR A 288
 None
 1.31A 1jipA-4rk6A:
undetectable		 1jipA-4rk6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 10 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
 None
 0.83A 1likA-4rk6A:
5.3		 1likA-4rk6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 10 GLY A  64
VAL A  63
LEU A  82
LEU A 145
ALA A 119
 None
 1.14A 1pbcA-4rk6A:
2.7		 1pbcA-4rk6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		4 / 8 VAL A 330
ASP A 169
HIS A 176
LEU A 333
 None
 1.21A 1pk2A-4rk6A:
undetectable		 1pk2A-4rk6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 LEU A  82
ALA A 301
ILE A 143
ILE A  95
LEU A  93
 None
 1.14A 2jn3A-4rk6A:
undetectable		 2jn3A-4rk6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		4 / 4 ILE A 244
PHE A 199
ILE A 179
THR A 246
 None
 1.00A 3ia4A-4rk6A:
2.5		 3ia4A-4rk6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		4 / 5 LEU A 123
LEU A  82
GLY A  81
GLY A 298
 None
 0.84A 3si7C-4rk6A:
undetectable
3si7D-4rk6A:
undetectable		 3si7C-4rk6A:
21.54
3si7D-4rk6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 LEU A 112
PHE A 121
VAL A  66
PHE A 305
GLY A  90
 None
 1.30A 4hvcB-4rk6A:
4.4		 4hvcB-4rk6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 LEU A 112
PHE A 121
VAL A  66
PHE A 305
GLY A  90
 None
 1.22A 4ydqA-4rk6A:
5.4		 4ydqA-4rk6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
 None
 0.83A 5kb6A-4rk6A:
6.0		 5kb6A-4rk6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
 None
 0.83A 5kb6B-4rk6A:
5.0		 5kb6B-4rk6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		5 / 12 GLY A  64
PHE A 121
TYR A  91
THR A  86
LEU A 123
 None
 1.29A 5nz0A-4rk6A:
undetectable		 5nz0A-4rk6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR
(Weissella
paramesenteroide
s) 		4 / 8 THR A 224
TYR A 216
THR A 185
ARG A 195
 None
None
None
GLC  A 401 (-2.6A)
 1.33A 5tzoA-4rk6A:
undetectable		 5tzoA-4rk6A:
18.93