SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 4 THR A 342
LEU A 341
LEU A 353
GLN A 357
 None
 1.10A 1fbmA-4rkcA:
undetectable		 1fbmA-4rkcA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		3 / 3 ALA A 302
VAL A 297
TRP A 307
 None
 0.97A 1gmkA-4rkcA:
undetectable
1gmkB-4rkcA:
undetectable		 1gmkA-4rkcA:
2.62
1gmkB-4rkcA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		3 / 3 ALA A 302
VAL A 297
TRP A 307
 None
 0.77A 1gmkC-4rkcA:
undetectable
1gmkD-4rkcA:
undetectable		 1gmkC-4rkcA:
2.62
1gmkD-4rkcA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
ASN A 242
GLY A 102
GLY A 110
 None
None
PMP  A 409 (-3.6A)
None
 0.85A 1jr1B-4rkcA:
undetectable		 1jr1B-4rkcA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 LEU A 341
TYR A 340
LEU A 380
LEU A  31
MET A 369
 None
 1.34A 1p33A-4rkcA:
4.0		 1p33A-4rkcA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 LEU A 341
TYR A 340
LEU A 380
LEU A  31
MET A 369
 None
 1.38A 1p33B-4rkcA:
undetectable		 1p33B-4rkcA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 TYR A 124
ASP A 173
ASN A 170
GLU A 161
 None
 1.10A 1rjdC-4rkcA:
2.3		 1rjdC-4rkcA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 TYR A  37
LEU A  31
LYS A  28
ASP A  23
 None
 1.31A 2w98A-4rkcA:
3.2
2w98B-4rkcA:
undetectable		 2w98A-4rkcA:
22.73
2w98B-4rkcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.34A 2xytD-4rkcA:
undetectable		 2xytD-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.26A 2xytG-4rkcA:
undetectable		 2xytG-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.24A 2xytH-4rkcA:
undetectable		 2xytH-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLQ_A_TESA1921_1
(ANDROGEN RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 11 LEU A  31
LEU A 353
GLN A 357
VAL A 393
ARG A 336
 None
 1.49A 2ylqA-4rkcA:
undetectable		 2ylqA-4rkcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		6 / 12 GLY A 103
ASN A 242
GLY A  70
ALA A  69
GLY A 257
LEU A 258
 PMP  A 409 (-3.4A)
None
None
None
None
None
 1.43A 3hs6B-4rkcA:
undetectable		 3hs6B-4rkcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 ARG A 374
GLY A  32
LEU A 325
SER A 320
ALA A 378
 NO3  A 402 (-3.1A)
None
None
NO3  A 405 ( 4.7A)
None
 1.04A 3kkzB-4rkcA:
3.1		 3kkzB-4rkcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 CYH A 181
ASN A 345
GLY A 218
ASP A 224
 None
NO3  A 407 (-3.1A)
None
None
 1.38A 3w9tE-4rkcA:
undetectable		 3w9tE-4rkcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 GLY A 218
VAL A 311
MET A 221
CYH A 180
 None
None
NO3  A 404 (-4.8A)
None
 0.84A 4c5nA-4rkcA:
4.9		 4c5nA-4rkcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 5 ARG A  63
ILE A  56
HIS A 289
GLY A 290
 None
 1.32A 4e7cC-4rkcA:
undetectable		 4e7cC-4rkcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 ASP A 188
ASP A 220
ASN A 345
ASP A 224
 None
None
NO3  A 407 (-3.1A)
None
 1.29A 4gkhJ-4rkcA:
undetectable		 4gkhJ-4rkcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 ASP A 211
ILE A 207
LEU A 176
HIS A 133
TRP A 130
 PMP  A 409 (-2.7A)
None
None
PMP  A 409 ( 4.7A)
PMP  A 409 ( 3.6A)
 1.19A 4j03A-4rkcA:
2.2		 4j03A-4rkcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 ILE A 101
TYR A 283
GLY A 102
GLY A 257
LEU A 275
 None
None
PMP  A 409 (-3.6A)
None
None
 1.11A 5eqbA-4rkcA:
2.5		 5eqbA-4rkcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 VAL A 174
LEU A 258
GLY A 110
ALA A 111
 None
 0.80A 5f1aA-4rkcA:
undetectable		 5f1aA-4rkcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 VAL A 174
LEU A 258
GLY A 110
ALA A 111
 None
 0.70A 5f1aB-4rkcA:
undetectable		 5f1aB-4rkcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 LEU A  81
ASN A 247
VAL A 311
TYR A 312
ASN A 242
 NO3  A 404 (-3.8A)
None
None
None
None
 1.38A 5kbwB-4rkcA:
undetectable		 5kbwB-4rkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		3 / 3 THR A 129
SER A 126
ASP A 188
 None
 0.85A 5kvaA-4rkcA:
undetectable		 5kvaA-4rkcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		3 / 3 THR A 129
SER A 126
ASP A 188
 None
 0.87A 5kvaB-4rkcA:
undetectable		 5kvaB-4rkcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
HIS A 178
VAL A 125
SER A 126
 None
PMP  A 409 ( 4.6A)
None
None
 1.03A 5m8rB-4rkcA:
undetectable		 5m8rB-4rkcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
HIS A 178
VAL A 125
SER A 126
 None
PMP  A 409 ( 4.6A)
None
None
 0.99A 5m8rD-4rkcA:
undetectable		 5m8rD-4rkcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 PRO A 208
LEU A 175
PHE A 209
LEU A 238
 None
 1.18A 5tl8A-4rkcA:
undetectable		 5tl8A-4rkcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 5 GLY A 218
ARG A 322
ASP A 224
MET A 221
 None
None
None
NO3  A 404 (-4.8A)
 0.89A 5ubbA-4rkcA:
4.3		 5ubbA-4rkcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 ILE A 207
LEU A 107
PHE A 137
PHE A 244
 None
 0.92A 5vkqA-4rkcA:
undetectable
5vkqB-4rkcA:
undetectable		 5vkqA-4rkcA:
13.25
5vkqB-4rkcA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 PHE A 244
ILE A 207
LEU A 107
PHE A 137
 None
 0.90A 5vkqA-4rkcA:
undetectable
5vkqD-4rkcA:
undetectable		 5vkqA-4rkcA:
13.25
5vkqD-4rkcA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 6 ILE A 367
LEU A  31
ARG A 360
THR A 354
 None
 1.08A 6nmfN-4rkcA:
undetectable
6nmfW-4rkcA:
undetectable		 6nmfN-4rkcA:
21.47
6nmfW-4rkcA:
9.57