SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4rkf RAS-RELATED PROTEIN
RAB-3
(Drosophila
melanogaster) 		4 / 4 ILE A 181
LEU A 178
VAL A 174
ALA A 165
 None
None
None
GNP  A 201 (-3.7A)
 0.95A 1mz9A-4rkfA:
undetectable		 1mz9A-4rkfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4rkf RAS-RELATED PROTEIN
RAB-3
(Drosophila
melanogaster) 		4 / 7 VAL A 158
GLY A 157
ILE A 119
VAL A 116
 None
 0.78A 1p2yA-4rkfA:
undetectable		 1p2yA-4rkfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4rkf RAS-RELATED PROTEIN
RAB-3
(Drosophila
melanogaster) 		4 / 6 ILE A  74
GLY A  33
ASN A 134
MET A 100
 None
GNP  A 201 (-3.2A)
GNP  A 201 (-3.3A)
None
 0.98A 5j4nB-4rkfA:
undetectable		 5j4nB-4rkfA:
17.15