SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4rkk LAFORIN
(Homo
sapiens) 		3 / 3 ALA A  12
VAL A   9
TRP A  60
 None
 0.95A 1c4dC-4rkkA:
undetectable
1c4dD-4rkkA:
undetectable		 1c4dC-4rkkA:
4.96
1c4dD-4rkkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4rkk LAFORIN
(Homo
sapiens) 		3 / 3 TRP A  60
ALA A  12
VAL A   9
 None
 0.88A 1c4dC-4rkkA:
undetectable
1c4dD-4rkkA:
undetectable		 1c4dC-4rkkA:
4.96
1c4dD-4rkkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 6 TRP A  32
LYS A  87
TRP A  99
GLY A 101
 GLC  A 417 ( 3.7A)
GLC  A 414 (-2.7A)
GLC  A 414 (-3.9A)
None
 0.48A 1dedA-4rkkA:
7.7		 1dedA-4rkkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifA-4rkkA:
undetectable		 1kifA-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifB-4rkkA:
undetectable		 1kifB-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifC-4rkkA:
undetectable		 1kifC-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifD-4rkkA:
undetectable		 1kifD-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifE-4rkkA:
undetectable		 1kifE-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifF-4rkkA:
undetectable		 1kifF-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifG-4rkkA:
undetectable		 1kifG-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifH-4rkkA:
undetectable		 1kifH-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4rkk LAFORIN
(Homo
sapiens) 		3 / 3 ALA A  12
VAL A   9
TRP A  60
 None
 0.94A 1tkqB-4rkkA:
undetectable		 1tkqB-4rkkA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.37A 1ve9A-4rkkA:
undetectable		 1ve9A-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4rkk LAFORIN
(Homo
sapiens) 		5 / 12 VAL A 292
LEU A 296
VAL A 303
THR A 238
GLY A 279
 None
 1.13A 2cbrA-4rkkA:
undetectable		 2cbrA-4rkkA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 5 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.30A 2du8G-4rkkA:
undetectable		 2du8G-4rkkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4rkk LAFORIN
(Homo
sapiens) 		3 / 3 PHE A   5
GLN A 293
PHE A  84
 None
 0.67A 3rv5A-4rkkA:
undetectable		 3rv5A-4rkkA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4rkk LAFORIN
(Homo
sapiens) 		5 / 9 PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
 None
 1.15A 4mm5A-4rkkA:
undetectable		 4mm5A-4rkkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4rkk LAFORIN
(Homo
sapiens) 		5 / 9 PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
 None
 1.27A 4mmbA-4rkkA:
0.0		 4mmbA-4rkkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4rkk LAFORIN
(Homo
sapiens) 		5 / 10 PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
 None
 1.25A 4mmdA-4rkkA:
undetectable		 4mmdA-4rkkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 7 MET A   1
PHE A   3
ARG A 290
LEU A 124
 None
 1.08A 4xk8A-4rkkA:
undetectable		 4xk8A-4rkkA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 4rkk LAFORIN
(Homo
sapiens) 		5 / 12 GLY A 271
ARG A 272
ASN A 201
HIS A 156
PHE A 145
 GLC  A 406 ( 3.3A)
PO4  A 401 ( 3.7A)
None
None
None
 1.03A 5arfA-4rkkA:
undetectable		 5arfA-4rkkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4rkk LAFORIN
(Homo
sapiens) 		4 / 6 PHE A   3
ASN A 116
ARG A   2
GLY A 120
 None
 1.14A 5o4yA-4rkkA:
undetectable		 5o4yA-4rkkA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4rkk LAFORIN
(Homo
sapiens) 		3 / 3 PHE A 317
ASP A 316
LYS A 320
 None
 0.88A 6awtD-4rkkA:
undetectable		 6awtD-4rkkA:
17.80