SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 9 ILE A 679
GLY A 622
TYR A 624
ILE A 644
ALA A 647
 None
 0.98A 1mrgA-4rkmA:
undetectable		 1mrgA-4rkmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 7 GLN A 296
ALA A 286
PHE A 212
GLU A  96
 None
None
HEM  A 807 (-4.7A)
None
 1.27A 1t9wA-4rkmA:
3.7		 1t9wA-4rkmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 SER A 294
TYR A 301
ALA A 287
TYR A 285
GLY A 238
 None
HEM  A 807 ( 3.8A)
None
SO2  A 814 (-4.8A)
None
 1.27A 1vpoH-4rkmA:
undetectable
1vpoL-4rkmA:
undetectable		 1vpoH-4rkmA:
14.34
1vpoL-4rkmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 GLU A 100
ALA A 287
ARG A 218
TYR A 285
TYR A 301
 None
None
HEM  A 807 (-3.8A)
SO2  A 814 (-4.8A)
HEM  A 807 ( 3.8A)
 1.44A 2htqA-4rkmA:
undetectable		 2htqA-4rkmA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 4 ARG A  93
GLY A  94
GLU A  63
SER A 107
 None
 1.27A 2xctS-4rkmA:
undetectable
2xctU-4rkmA:
undetectable		 2xctS-4rkmA:
21.20
2xctU-4rkmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 8 ASN A 104
SER A 107
ARG A 112
SER A 120
 None
 1.00A 2zw9B-4rkmA:
undetectable		 2zw9B-4rkmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 VAL A 202
PHE A 310
PHE A 318
LEU A 322
ALA A 297
 HEM  A 807 (-4.6A)
None
None
None
None
 1.41A 3apxA-4rkmA:
undetectable		 3apxA-4rkmA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 6 SER A 107
GLY A  94
GLU A  62
GLU A  63
 None
 1.07A 3k9fA-4rkmA:
undetectable
3k9fB-4rkmA:
undetectable
3k9fD-4rkmA:
undetectable		 3k9fA-4rkmA:
21.52
3k9fB-4rkmA:
21.52
3k9fD-4rkmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 9 GLY A 219
VAL A  85
GLN A 234
ASN A 240
GLY A 238
 None
 1.45A 3kmoA-4rkmA:
undetectable		 3kmoA-4rkmA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 GLY A 277
ASN A 240
LEU A 282
THR A 268
LEU A 269
 None
 1.00A 3mteB-4rkmA:
undetectable		 3mteB-4rkmA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 GLU A 171
GLY A 203
THR A 162
HIS A 204
THR A 201
 None
HEM  A 807 (-3.6A)
HEM  A 809 (-3.5A)
HEM  A 809 ( 3.9A)
None
 1.48A 3r75A-4rkmA:
undetectable		 3r75A-4rkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 11 GLU A 171
GLY A 203
THR A 162
HIS A 204
THR A 201
 None
HEM  A 807 (-3.6A)
HEM  A 809 (-3.5A)
HEM  A 809 ( 3.9A)
None
 1.47A 3r76A-4rkmA:
undetectable		 3r76A-4rkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 11 GLU A 171
GLY A 203
THR A 162
HIS A 204
THR A 201
 None
HEM  A 807 (-3.6A)
HEM  A 809 (-3.5A)
HEM  A 809 ( 3.9A)
None
 1.45A 3r76B-4rkmA:
undetectable		 3r76B-4rkmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4rkm MCCA
(Wolinella
succinogenes) 		3 / 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 0.95A 3u9fF-4rkmA:
undetectable		 3u9fF-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4rkm MCCA
(Wolinella
succinogenes) 		3 / 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 1.05A 3u9fG-4rkmA:
undetectable		 3u9fG-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4rkm MCCA
(Wolinella
succinogenes) 		3 / 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 1.08A 3u9fL-4rkmA:
undetectable		 3u9fL-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4rkm MCCA
(Wolinella
succinogenes) 		3 / 3 PHE A 592
CYH A 562
HIS A 579
 HEM  A 813 ( 4.9A)
HEM  A 813 (-2.0A)
HEM  A 813 (-3.2A)
 1.03A 3u9fS-4rkmA:
undetectable		 3u9fS-4rkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 GLY A 273
ASP A 274
LYS A 291
VAL A 236
LEU A 269
 None
 1.01A 4a81A-4rkmA:
undetectable		 4a81A-4rkmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 7 MET A 492
ILE A 517
VAL A 530
TRP A 544
 None
 1.08A 4f4dA-4rkmA:
undetectable		 4f4dA-4rkmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 8 MET A 492
ILE A 517
VAL A 530
TRP A 544
 None
 1.21A 4f4dB-4rkmA:
undetectable		 4f4dB-4rkmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 8 ASP A 505
THR A 511
MET A 395
GLY A 396
 None
 1.00A 4fo4A-4rkmA:
undetectable		 4fo4A-4rkmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4rkm MCCA
(Wolinella
succinogenes) 		3 / 3 LEU A 672
LYS A 669
THR A 668
 None
 0.55A 4lj0A-4rkmA:
undetectable		 4lj0A-4rkmA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 TYR A 133
ALA A 320
TYR A 319
PHE A 310
SER A 316
 None
 1.10A 4mmdB-4rkmA:
undetectable		 4mmdB-4rkmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 12 PHE A 509
TYR A 499
ASN A 275
ALA A 283
GLY A 276
 None
BU3  A 804 ( 3.7A)
None
None
None
 1.44A 4oadA-4rkmA:
undetectable		 4oadA-4rkmA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 7 ALA A 682
LEU A 623
LEU A 626
ILE A 685
 None
 0.86A 4ubsA-4rkmA:
undetectable		 4ubsA-4rkmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 9 ILE A 679
GLY A 622
TYR A 624
ILE A 644
ALA A 647
 None
 0.97A 4yp2B-4rkmA:
2.0		 4yp2B-4rkmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 5 ALA A 237
TYR A 221
HIS A 169
PHE A 211
 None
 1.34A 4ze2A-4rkmA:
undetectable		 4ze2A-4rkmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 6 SER A 294
GLN A 241
SER A 284
PRO A 190
 None
 1.15A 5c6pA-4rkmA:
undetectable		 5c6pA-4rkmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 9 ILE A 679
GLY A 622
TYR A 624
ILE A 644
ALA A 647
 None
 0.97A 5cf9B-4rkmA:
undetectable		 5cf9B-4rkmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 6 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.06A 5xdhA-4rkmA:
undetectable
5xdhC-4rkmA:
undetectable		 5xdhA-4rkmA:
8.91
5xdhC-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 5 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.13A 5xdhB-4rkmA:
undetectable		 5xdhB-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 6 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.31A 5xdhA-4rkmA:
undetectable
5xdhC-4rkmA:
undetectable		 5xdhA-4rkmA:
8.91
5xdhC-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4rkm MCCA
(Wolinella
succinogenes) 		4 / 5 HIS A  74
MET A 293
VAL A  90
LEU A  88
 None
 1.06A 5xdhD-4rkmA:
undetectable		 5xdhD-4rkmA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 4rkm MCCA
(Wolinella
succinogenes) 		5 / 11 TYR A 319
SER A 129
THR A 130
TYR A 133
ALA A 297
 None
 1.31A 6d6tD-4rkmA:
2.4
6d6tE-4rkmA:
3.5		 6d6tD-4rkmA:
19.42
6d6tE-4rkmA:
17.09