SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 8 TYR A  84
LEU A 331
ASP A 153
LEU A 152
 LBT  A 401 ( 3.7A)
None
LBT  A 401 (-3.0A)
None
 1.05A 1e7cA-4rkrA:
undetectable		 1e7cA-4rkrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 GLY A 158
GLN A 141
VAL A 151
ALA A 137
 None
 1.00A 1p6kA-4rkrA:
undetectable		 1p6kA-4rkrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 10 LEU A 301
GLU A 303
LEU A 331
ARG A 334
LEU A 152
 None
 1.09A 1pcgA-4rkrA:
undetectable		 1pcgA-4rkrA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		6 / 10 LEU A 331
ALA A 307
ILE A 150
LEU A 311
ASP A 153
LEU A 152
 None
None
None
None
LBT  A 401 (-3.0A)
None
 1.15A 1yi4A-4rkrA:
undetectable		 1yi4A-4rkrA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 ASP A 106
SER A 114
LEU A 116
GLY A 115
 None
 1.04A 2j2pA-4rkrA:
undetectable
2j2pC-4rkrA:
undetectable		 2j2pA-4rkrA:
22.33
2j2pC-4rkrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 LEU A 149
ALA A 128
GLY A 145
ILE A 150
LEU A 315
 None
 1.28A 3gyqA-4rkrA:
2.1
3gyqB-4rkrA:
3.4		 3gyqA-4rkrA:
23.05
3gyqB-4rkrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 10 LEU A 214
ILE A 186
ARG A 183
GLY A 280
MET A 297
 None
 1.45A 3hcpB-4rkrA:
3.6		 3hcpB-4rkrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 LEU A 301
GLU A 303
LEU A 331
ARG A 334
LEU A 152
 None
 1.04A 3hm1A-4rkrA:
undetectable		 3hm1A-4rkrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 ILE A 130
GLY A 131
ALA A 118
ALA A 137
ILE A  77
 None
 1.04A 3jb1A-4rkrA:
2.5		 3jb1A-4rkrA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 11 ILE A 279
GLY A 280
ASP A 255
LEU A 335
ALA A 174
 None
 1.13A 3kw2A-4rkrA:
undetectable		 3kw2A-4rkrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 11 ILE A 279
GLY A 280
ASP A 255
LEU A 335
ALA A 174
 None
 1.19A 3kw2B-4rkrA:
2.6		 3kw2B-4rkrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 ALA A 118
HIS A 121
GLY A  74
ALA A 308
LEU A 152
 None
 1.22A 3tm4A-4rkrA:
2.2		 3tm4A-4rkrA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 ALA A 118
HIS A 121
GLY A  74
ALA A 308
LEU A 152
 None
 1.20A 3tm4B-4rkrA:
2.2		 3tm4B-4rkrA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 TYR A  84
GLY A 131
GLY A 115
ALA A 308
PHE A  85
 LBT  A 401 ( 3.7A)
None
None
None
None
 1.00A 3vywC-4rkrA:
3.6		 3vywC-4rkrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 7 HIS A 333
TYR A 167
ASN A  82
ARG A 206
 None
None
LBT  A 401 (-3.3A)
LBT  A 401 (-2.8A)
 1.00A 4o7gA-4rkrA:
undetectable
4o7gB-4rkrA:
undetectable		 4o7gA-4rkrA:
22.90
4o7gB-4rkrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		5 / 12 GLY A 161
ALA A 160
ALA A 128
VAL A  73
GLN A 141
 None
 1.39A 4ryaA-4rkrA:
1.7		 4ryaA-4rkrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		3 / 3 VAL A 336
THR A 296
ARG A 338
 None
 0.72A 5b2sB-4rkrA:
undetectable		 5b2sB-4rkrA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		3 / 3 VAL A 336
THR A 296
ARG A 338
 None
 0.75A 5b2tB-4rkrA:
undetectable		 5b2tB-4rkrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.24A 5bphA-4rkrA:
6.7		 5bphA-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 4 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.21A 5bphC-4rkrA:
4.7		 5bphC-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 6 TYR A  84
GLY A 305
SER A  91
LEU A 301
 LBT  A 401 ( 3.7A)
None
None
None
 1.22A 5bphD-4rkrA:
4.6		 5bphD-4rkrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 7 VAL A 129
ALA A  76
GLY A 115
VAL A 119
 None
 0.77A 5fpdA-4rkrA:
2.3		 5fpdA-4rkrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Arthrobacter
sp.
FB24) 		4 / 7 LEU A 178
LEU A 290
GLY A 260
GLY A 249
 None
 0.76A 6eu9D-4rkrA:
undetectable		 6eu9D-4rkrA:
14.14