SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 LEU A 146
LEU A 135
LEU A  78
GLY A 116
 None
 0.97A 1a4lC-4rkzA:
undetectable		 1a4lC-4rkzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 7 GLY A 157
HIS A 159
THR A  27
THR A  29
 None
 0.98A 1gtnJ-4rkzA:
undetectable
1gtnK-4rkzA:
undetectable		 1gtnJ-4rkzA:
13.62
1gtnK-4rkzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 LEU A 261
LEU A 257
PHE A 181
VAL A 274
ALA A 180
 None
 1.18A 1n5xA-4rkzA:
undetectable		 1n5xA-4rkzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 LEU A 261
LEU A 257
PHE A 181
VAL A 274
ALA A 180
 None
 1.18A 1n5xB-4rkzA:
undetectable		 1n5xB-4rkzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 11 LEU A 135
ALA A 117
VAL A 138
TYR A  81
LEU A  78
 None
 1.41A 1qabE-4rkzA:
undetectable		 1qabE-4rkzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 11 LEU A 242
GLY A  20
ILE A 241
ARG A 204
HIS A  32
 None
 1.39A 1tmxA-4rkzA:
undetectable		 1tmxA-4rkzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 11 ASP A 234
ARG A 204
ILE A  37
LEU A 230
ILE A 227
 None
 1.30A 1yatA-4rkzA:
undetectable		 1yatA-4rkzA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		6 / 11 PHE A  89
VAL A  94
PHE A  85
ILE A   6
THR A  50
LEU A  78
 None
 1.43A 1z11A-4rkzA:
undetectable		 1z11A-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		6 / 11 PHE A  89
VAL A  94
ILE A   6
THR A  50
ILE A 115
LEU A  78
 None
 1.49A 1z11B-4rkzA:
undetectable		 1z11B-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		6 / 11 PHE A  89
VAL A  94
PHE A  85
ILE A   6
THR A  50
LEU A  78
 None
 1.43A 1z11B-4rkzA:
undetectable		 1z11B-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		6 / 10 PHE A  89
VAL A  94
ILE A   6
THR A  50
ILE A 115
LEU A  78
 None
 1.50A 1z11C-4rkzA:
undetectable		 1z11C-4rkzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 9 PHE A 228
GLY A 226
ILE A 215
ALA A 231
VAL A  16
 None
 1.05A 2drdA-4rkzA:
3.4		 2drdA-4rkzA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 GLU A 318
PRO A 317
ILE A   6
GLY A   7
 None
 1.02A 2qeuA-4rkzA:
undetectable
2qeuC-4rkzA:
undetectable		 2qeuA-4rkzA:
17.37
2qeuC-4rkzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 6 GLY A   7
GLY A 116
PHE A  85
PHE A  89
 None
 0.97A 2qx6A-4rkzA:
undetectable
2qx6B-4rkzA:
undetectable		 2qx6A-4rkzA:
21.55
2qx6B-4rkzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 11 SER A 108
SER A 139
ALA A 112
GLY A 111
ALA A 110
 ADP  A 401 (-3.2A)
None
None
ADP  A 401 (-3.3A)
None
 1.28A 2xh9A-4rkzA:
undetectable		 2xh9A-4rkzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 10 SER A 108
SER A 139
ALA A 112
GLY A 111
ALA A 110
 ADP  A 401 (-3.2A)
None
None
ADP  A 401 (-3.3A)
None
 1.26A 2xh9B-4rkzA:
undetectable		 2xh9B-4rkzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_B_TC9B1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 11 TYR A  53
SER A   5
SER A 114
SER A   8
SER A  98
 None
None
None
None
ADP  A 401 (-2.7A)
 1.44A 2xytB-4rkzA:
0.0
2xytC-4rkzA:
0.0
2xytG-4rkzA:
0.0		 2xytB-4rkzA:
18.40
2xytC-4rkzA:
18.40
2xytG-4rkzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 9 THR A 275
SER A 155
ILE A 152
ILE A  14
GLY A 106
 3S4  A 402 (-3.7A)
None
None
None
ADP  A 401 (-3.4A)
 1.13A 3cv9A-4rkzA:
undetectable		 3cv9A-4rkzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 ASN A 248
GLY A 277
SER A 278
ILE A 273
GLY A  15
 None
3S4  A 402 ( 4.8A)
None
None
3S4  A 402 (-3.6A)
 1.21A 4obwC-4rkzA:
undetectable		 4obwC-4rkzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 7 ILE A  22
LEU A  31
GLY A  20
GLY A  21
 None
 0.84A 5a06B-4rkzA:
undetectable		 5a06B-4rkzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 SER A  48
ARG A 144
GLY A 148
THR A 153
 ADP  A 401 (-3.4A)
3S4  A 402 (-2.8A)
None
None
 1.19A 5btiA-4rkzA:
1.7
5btiB-4rkzA:
undetectable		 5btiA-4rkzA:
21.92
5btiB-4rkzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 SER A  48
ARG A 144
GLY A 148
THR A 153
 ADP  A 401 (-3.4A)
3S4  A 402 (-2.8A)
None
None
 1.13A 5btiC-4rkzA:
2.1
5btiD-4rkzA:
undetectable		 5btiC-4rkzA:
21.92
5btiD-4rkzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 SER A 114
GLY A 116
LEU A 135
ILE A  14
TYR A  39
 None
 1.48A 5fepA-4rkzA:
undetectable		 5fepA-4rkzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 SER A 114
GLY A 116
LEU A 135
ILE A  14
TYR A  39
 None
 1.49A 5fesA-4rkzA:
undetectable		 5fesA-4rkzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 6 GLY A 143
ASP A 109
SER A 139
ARG A 136
 None
 1.04A 6dwdA-4rkzA:
undetectable
6dwdC-4rkzA:
undetectable		 6dwdA-4rkzA:
24.02
6dwdC-4rkzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 ARG A 144
ALA A  38
TYR A  39
ILE A 176
 3S4  A 402 (-2.8A)
None
None
None
 1.33A 6f6sA-4rkzA:
undetectable
6f6sB-4rkzA:
0.0		 6f6sA-4rkzA:
14.06
6f6sB-4rkzA:
12.76