SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 ASP A  89
ASP A  86
ASP A  69
 None
 0.78A 1eizA-4rl1A:
undetectable		 1eizA-4rl1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 ASP A  89
ASP A  86
ASP A  69
 None
 0.77A 1ej0A-4rl1A:
undetectable		 1ej0A-4rl1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 5 ASP A 223
VAL A 224
ASP A  86
GLN A  35
 None
 1.46A 1n2xB-4rl1A:
undetectable		 1n2xB-4rl1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 7 SER A 346
PRO A 305
HIS A 304
GLY A 338
 None
 0.84A 2ddwB-4rl1A:
undetectable		 2ddwB-4rl1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 11 THR A 259
VAL A 258
PHE A 254
ALA A 126
SER A 130
 None
 1.40A 2ij7A-4rl1A:
undetectable		 2ij7A-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 11 THR A 259
VAL A 258
PHE A 254
ALA A 127
SER A 130
 None
 1.23A 2ij7A-4rl1A:
undetectable		 2ij7A-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 10 THR A 259
VAL A 258
PHE A 254
ALA A 126
SER A 130
 None
 1.39A 2ij7D-4rl1A:
undetectable		 2ij7D-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 10 THR A 259
VAL A 258
PHE A 254
ALA A 127
SER A 130
 None
 1.25A 2ij7D-4rl1A:
undetectable		 2ij7D-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 10 THR A 259
VAL A 258
PHE A 254
ALA A 126
SER A 130
 None
 1.42A 2ij7F-4rl1A:
undetectable		 2ij7F-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 10 THR A 259
VAL A 258
PHE A 254
ALA A 127
SER A 130
 None
 1.24A 2ij7F-4rl1A:
undetectable		 2ij7F-4rl1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 ASP A  89
ASP A  86
ASP A  69
 None
 0.74A 3douA-4rl1A:
undetectable		 3douA-4rl1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 9 VAL A 142
PHE A  96
ALA A  59
VAL A  72
VAL A  68
 None
 1.26A 3me6C-4rl1A:
undetectable		 3me6C-4rl1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 12 HIS A 227
SER A 120
ASN A 276
GLN A  35
LEU A 144
 None
 1.44A 4abzA-4rl1A:
undetectable		 4abzA-4rl1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 5 GLU A 284
ARG A 288
PRO A 191
SER A 193
 None
 1.46A 4k17B-4rl1A:
undetectable		 4k17B-4rl1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 9 VAL A 224
VAL A 195
ALA A 187
THR A 280
ALA A 226
 None
 1.18A 4oqrA-4rl1A:
undetectable		 4oqrA-4rl1A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		5 / 12 VAL A 281
LEU A 311
PHE A 298
PHE A 283
GLY A 118
 None
 1.35A 4pevC-4rl1A:
3.1		 4pevC-4rl1A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 7 ALA A 126
PRO A  33
MET A  99
LEU A 117
 None
 1.02A 5dzkD-4rl1A:
undetectable
5dzkR-4rl1A:
undetectable		 5dzkD-4rl1A:
21.51
5dzkR-4rl1A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 7 LEU A 263
SER A 130
ILE A 124
GLU A 123
 None
 0.97A 5n5dA-4rl1A:
undetectable		 5n5dA-4rl1A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 THR A 308
GLU A 300
HIS A 304
 None
 0.91A 5xioA-4rl1A:
undetectable		 5xioA-4rl1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 THR A 308
GLU A 300
HIS A 304
 None
 0.90A 5xiqB-4rl1A:
undetectable		 5xiqB-4rl1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		3 / 3 ARG A 218
ILE A 220
SER A 160
 None
 0.82A 5zw2A-4rl1A:
undetectable		 5zw2A-4rl1A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 7 GLU A 284
ARG A 192
THR A 164
PRO A 165
 None
 1.37A 6a4iB-4rl1A:
undetectable		 6a4iB-4rl1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1
(Streptomyces
avermitilis) 		4 / 7 LEU A 135
ALA A 138
ALA A 139
THR A 143
 None
 0.64A 6a7jA-4rl1A:
undetectable		 6a7jA-4rl1A:
13.97