SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 9 TYR A 130
PHE A 157
GLY A 204
ASP A 245
TYR A 308
 ACT  A 403 (-3.9A)
None
None
ACT  A 403 (-2.7A)
ACT  A 403 (-4.5A)
 0.68A 1e9lA-4rl3A:
6.7		 1e9lA-4rl3A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 8 ILE A 261
LEU A 202
MET A 199
GLY A 241
 None
 1.00A 1os6A-4rl3A:
undetectable		 1os6A-4rl3A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 11 SER A 362
CYH A 356
LEU A 365
THR A 364
VAL A 352
 None
 1.11A 1pkvA-4rl3A:
undetectable
1pkvB-4rl3A:
undetectable		 1pkvA-4rl3A:
14.98
1pkvB-4rl3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 11 VAL A 352
SER A 362
CYH A 356
LEU A 365
THR A 364
 None
 1.13A 1pkvA-4rl3A:
undetectable
1pkvB-4rl3A:
undetectable		 1pkvA-4rl3A:
14.98
1pkvB-4rl3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 12 TYR A 308
ALA A 133
TYR A 130
GLY A 132
LEU A 134
 ACT  A 403 (-4.5A)
EDO  A 401 (-3.3A)
ACT  A 403 (-3.9A)
EDO  A 401 (-4.1A)
EDO  A 401 (-4.0A)
 1.23A 1vpoH-4rl3A:
undetectable
1vpoL-4rl3A:
undetectable		 1vpoH-4rl3A:
23.18
1vpoL-4rl3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		3 / 3 TYR A 310
GLY A 346
PHE A 307
 None
 0.71A 2m2pB-4rl3A:
undetectable		 2m2pB-4rl3A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 7 ALA A 280
TYR A 289
ASP A 243
TYR A 130
 ACT  A 403 ( 4.1A)
None
None
ACT  A 403 (-3.9A)
 1.48A 2pncA-4rl3A:
undetectable		 2pncA-4rl3A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		6 / 9 TYR A 130
PHE A 157
GLY A 204
ASP A 245
GLN A 306
TYR A 308
 ACT  A 403 (-3.9A)
None
None
ACT  A 403 (-2.7A)
ACT  A 403 (-3.2A)
ACT  A 403 (-4.5A)
 0.42A 2uy4A-4rl3A:
20.3		 2uy4A-4rl3A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 5 SER A 339
TYR A 319
VAL A 336
TYR A 308
 None
None
None
ACT  A 403 (-4.5A)
 1.46A 2x7hA-4rl3A:
undetectable		 2x7hA-4rl3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 5 SER A 339
TYR A 319
VAL A 336
TYR A 308
 None
None
None
ACT  A 403 (-4.5A)
 1.47A 2x7hB-4rl3A:
undetectable		 2x7hB-4rl3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		6 / 11 TYR A 130
PHE A 157
GLY A 204
ASP A 245
GLN A 306
TYR A 308
 ACT  A 403 (-3.9A)
None
None
ACT  A 403 (-2.7A)
ACT  A 403 (-3.2A)
ACT  A 403 (-4.5A)
 0.65A 2xtkA-4rl3A:
21.5		 2xtkA-4rl3A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		6 / 10 TYR A 130
PHE A 157
GLY A 204
ASP A 245
GLN A 306
TYR A 308
 ACT  A 403 (-3.9A)
None
None
ACT  A 403 (-2.7A)
ACT  A 403 (-3.2A)
ACT  A 403 (-4.5A)
 0.64A 2xtkB-4rl3A:
21.5		 2xtkB-4rl3A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		3 / 3 PRO A 281
PHE A 307
ALA A 326
 None
 0.59A 3itaD-4rl3A:
undetectable		 3itaD-4rl3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 6 ILE A 261
LEU A 202
MET A 199
GLY A 241
 None
 1.05A 3sj1X-4rl3A:
undetectable		 3sj1X-4rl3A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 7 ILE A 154
GLY A 241
VAL A 276
SER A 278
 None
 1.00A 4a3uB-4rl3A:
10.8		 4a3uB-4rl3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 7 PHE A 214
LEU A 292
VAL A 223
VAL A 219
 None
 0.99A 4cp4A-4rl3A:
undetectable		 4cp4A-4rl3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 11 SER A 362
LEU A 365
THR A 364
ALA A 338
VAL A 352
 None
 1.13A 4e0fA-4rl3A:
undetectable		 4e0fA-4rl3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 8 ASP A 205
PHE A 282
VAL A 285
HIS A 248
 None
 1.15A 4f5zA-4rl3A:
2.9		 4f5zA-4rl3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 6 TRP A 176
ASN A 173
TYR A 237
LEU A 233
 None
 1.23A 4f8yA-4rl3A:
2.4
4f8yB-4rl3A:
2.2		 4f8yA-4rl3A:
21.11
4f8yB-4rl3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 11 VAL A 200
ILE A 242
SER A 278
PHE A 172
LEU A 268
 None
 1.48A 4lhmA-4rl3A:
undetectable		 4lhmA-4rl3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 5 LEU A 337
ASP A 243
GLU A 129
VAL A 196
 None
 1.30A 4nkvA-4rl3A:
undetectable		 4nkvA-4rl3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 12 VAL A 180
PHE A 383
THR A 342
SER A 379
GLY A 343
 None
 1.23A 4olfA-4rl3A:
undetectable		 4olfA-4rl3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 12 GLY A 204
ASP A 245
PHE A 172
ILE A 159
HIS A 248
 None
ACT  A 403 (-2.7A)
None
None
None
 1.43A 4wh5A-4rl3A:
undetectable		 4wh5A-4rl3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 10 ASN A 169
ASP A 160
ILE A 242
LEU A 230
LEU A 264
 None
 1.07A 4xj7A-4rl3A:
undetectable
4xj7B-4rl3A:
undetectable		 4xj7A-4rl3A:
22.36
4xj7B-4rl3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 10 LEU A 230
LEU A 264
ASN A 169
ASP A 160
ILE A 242
 None
 1.12A 4xj7C-4rl3A:
undetectable
4xj7D-4rl3A:
undetectable		 4xj7C-4rl3A:
22.36
4xj7D-4rl3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 9 SER A 278
GLY A 241
ALA A 158
VAL A 200
ILE A 234
 None
 1.43A 5i3cA-4rl3A:
undetectable		 5i3cA-4rl3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 12 ASP A 283
SER A 309
TYR A 310
SER A 339
TYR A 323
 None
 1.48A 5iqeD-4rl3A:
undetectable		 5iqeD-4rl3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 7 PHE A 340
ILE A 154
SER A 376
THR A 342
 None
 0.99A 5vkqA-4rl3A:
undetectable
5vkqD-4rl3A:
undetectable		 5vkqA-4rl3A:
9.91
5vkqD-4rl3A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		5 / 12 GLY A 333
PHE A 305
VAL A 303
LEU A 302
ILE A 300
 None
 1.03A 6ectA-4rl3A:
undetectable		 6ectA-4rl3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4rl3 CHITINASE A
(Pteris
ryukyuensis) 		4 / 6 GLN A 388
LEU A 353
SER A 350
PHE A 340
 None
 1.02A 6ekuA-4rl3A:
undetectable		 6ekuA-4rl3A:
18.80