SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.47A 1h1dA-4rl4A:
2.4		 1h1dA-4rl4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.45A 1vidA-4rl4A:
undetectable		 1vidA-4rl4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 7 GLY A  62
ASP A  59
GLY A  58
HIS A  52
 None
 0.92A 4c5nA-4rl4A:
3.0		 4c5nA-4rl4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.46A 4xucA-4rl4A:
2.3		 4xucA-4rl4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 6 LYS A 154
TYR A 130
GLY A  93
GLU A  92
 PPV  A 201 (-2.8A)
None
None
None
 1.35A 5emlA-4rl4A:
undetectable		 5emlA-4rl4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.46A 5fhrA-4rl4A:
undetectable		 5fhrA-4rl4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.49A 5fhrB-4rl4A:
undetectable		 5fhrB-4rl4A:
21.62