SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 6 PHE A 383
VAL A 387
LEU A 404
SER A 481
 None
 1.06A 1wrlB-4rl5A:
undetectable		 1wrlB-4rl5A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		5 / 10 LEU A 469
ALA A 507
VAL A 584
ALA A 585
PHE A 628
 None
 1.15A 1xp0A-4rl5A:
undetectable		 1xp0A-4rl5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 5 PHE A 414
PHE A 333
LEU A 332
PHE A 380
 None
 1.36A 2y69C-4rl5A:
3.6
2y69J-4rl5A:
undetectable		 2y69C-4rl5A:
17.52
2y69J-4rl5A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 5 PHE A 414
PHE A 333
LEU A 332
PHE A 380
 None
 1.33A 3abmC-4rl5A:
2.4
3abmJ-4rl5A:
undetectable		 3abmC-4rl5A:
17.52
3abmJ-4rl5A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 5 PHE A 414
PHE A 333
LEU A 332
PHE A 380
 None
 1.38A 3abmP-4rl5A:
2.3
3abmW-4rl5A:
undetectable		 3abmP-4rl5A:
17.52
3abmW-4rl5A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 5 GLN A 424
THR A 420
LEU A 332
LEU A 336
 None
 1.01A 4lvcB-4rl5A:
undetectable		 4lvcB-4rl5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1
(Arabidopsis
thaliana) 		4 / 4 GLN A 424
THR A 420
LEU A 332
LEU A 336
 None
 1.00A 5m5kB-4rl5A:
undetectable		 5m5kB-4rl5A:
21.09