SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 191
ALA A 361
THR A 321
HIS A 194
 None
 0.88A 1c9sT-4rl6A:
undetectable
1c9sU-4rl6A:
undetectable		 1c9sT-4rl6A:
11.47
1c9sU-4rl6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 323
ALA A 361
HIS A 194
THR A 321
 None
 0.91A 1c9sT-4rl6A:
undetectable
1c9sU-4rl6A:
undetectable		 1c9sT-4rl6A:
11.47
1c9sU-4rl6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 191
ALA A 361
THR A 321
HIS A 194
 None
 0.91A 1gtfL-4rl6A:
undetectable
1gtfM-4rl6A:
undetectable		 1gtfL-4rl6A:
11.47
1gtfM-4rl6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 323
ALA A 361
HIS A 194
THR A 321
 None
 0.91A 1gtfL-4rl6A:
undetectable
1gtfM-4rl6A:
undetectable		 1gtfL-4rl6A:
11.47
1gtfM-4rl6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 SER A 216
PHE A 132
GLU A 225
GLY A 131
 None
 1.34A 1icrA-4rl6A:
undetectable
1icrB-4rl6A:
undetectable		 1icrA-4rl6A:
21.93
1icrB-4rl6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 4 SER A 216
PHE A 132
GLU A 225
GLY A 131
 None
 1.36A 1icvA-4rl6A:
undetectable
1icvB-4rl6A:
undetectable		 1icvA-4rl6A:
21.93
1icvB-4rl6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 225
GLY A 131
SER A 216
PHE A 132
 None
 1.33A 1icvC-4rl6A:
undetectable
1icvD-4rl6A:
undetectable		 1icvC-4rl6A:
21.93
1icvD-4rl6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 225
GLY A 131
SER A 216
PHE A 132
 None
 1.31A 1kqbA-4rl6A:
undetectable
1kqbB-4rl6A:
undetectable		 1kqbA-4rl6A:
20.47
1kqbB-4rl6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 ILE A 231
GLU A 234
ARG A 267
ASP A 419
 None
 0.98A 1mt1B-4rl6A:
undetectable
1mt1C-4rl6A:
undetectable		 1mt1B-4rl6A:
14.02
1mt1C-4rl6A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 225
PHE A 136
ARG A 209
ALA A 134
 None
 1.49A 1oniE-4rl6A:
1.2
1oniF-4rl6A:
1.2		 1oniE-4rl6A:
16.39
1oniF-4rl6A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 365
GLY A 164
THR A 166
GLU A 252
ILE A 362
 None
 1.32A 2akeA-4rl6A:
4.0		 2akeA-4rl6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 365
GLY A 164
THR A 166
GLU A 252
ILE A 362
 None
 1.33A 2azxA-4rl6A:
2.9		 2azxA-4rl6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 365
GLY A 164
THR A 166
GLU A 252
ILE A 362
 None
 1.35A 2azxB-4rl6A:
3.0		 2azxB-4rl6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A 103
MET A  93
THR A  91
LEU A  90
 None
 1.17A 2eimJ-4rl6A:
undetectable		 2eimJ-4rl6A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 PHE A 136
SER A 216
LEU A 248
 None
 0.71A 2w1bA-4rl6A:
undetectable		 2w1bA-4rl6A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 MET A 229
GLU A 210
ASN A 201
 None
 1.13A 3a27A-4rl6A:
5.3		 3a27A-4rl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 164
SER A 170
ILE A 184
LEU A 187
ILE A 327
 None
 1.22A 3adsB-4rl6A:
undetectable		 3adsB-4rl6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A 103
MET A  93
THR A  91
LEU A  90
 None
 1.23A 3ag1J-4rl6A:
undetectable		 3ag1J-4rl6A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A 109
GLN A 141
GLN A  88
GLU A  66
 None
None
NDP  A 501 (-3.5A)
None
 1.38A 4azvA-4rl6A:
undetectable		 4azvA-4rl6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 123
THR A 133
GLU A 110
 None
 0.77A 4df3B-4rl6A:
6.9		 4df3B-4rl6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.05A 4fp9A-4rl6A:
4.0		 4fp9A-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.04A 4fp9C-4rl6A:
4.0		 4fp9C-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.04A 4fp9D-4rl6A:
4.1		 4fp9D-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
GLY A 323
LEU A 187
GLY A 328
PRO A 238
 None
 1.04A 4fp9F-4rl6A:
3.4		 4fp9F-4rl6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 402
VAL A 165
PRO A 369
SER A 359
GLY A  11
 None
None
None
None
NDP  A 501 (-3.7A)
 1.11A 4hvcB-4rl6A:
2.4		 4hvcB-4rl6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 393
GLY A 386
GLU A 150
ALA A 151
ALA A 385
 None
 1.16A 4pclA-4rl6A:
6.8		 4pclA-4rl6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 6 VAL A  83
LEU A  43
ILE A  17
ALA A  16
 None
 0.75A 4zf8A-4rl6A:
undetectable		 4zf8A-4rl6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		3 / 3 THR A 365
ASP A 188
GLU A 252
 None
 0.81A 5fa8A-4rl6A:
undetectable		 5fa8A-4rl6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 357
VAL A  15
TYR A 364
GLN A 360
 None
 1.32A 5qggA-4rl6A:
undetectable		 5qggA-4rl6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 357
VAL A  15
TYR A 364
GLN A 360
 None
 1.35A 5qgoA-4rl6A:
undetectable		 5qgoA-4rl6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 357
VAL A  15
TYR A 364
GLN A 360
 None
 1.32A 5qgpA-4rl6A:
undetectable		 5qgpA-4rl6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 4 VAL A 357
VAL A  15
TYR A 364
GLN A 360
 None
 1.26A 5qgqA-4rl6A:
undetectable		 5qgqA-4rl6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 387
LEU A  97
CYH A  96
ASP A 105
 None
 1.44A 5vcvA-4rl6A:
undetectable		 5vcvA-4rl6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A 103
MET A  93
THR A  91
LEU A  90
 None
 1.19A 5wauJ-4rl6A:
undetectable		 5wauJ-4rl6A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A 103
MET A  93
THR A  91
LEU A  90
 None
 1.20A 5x1fW-4rl6A:
undetectable		 5x1fW-4rl6A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4rl6 SACCHAROPINE
DEHYDROGENASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 402
VAL A 165
PRO A 369
SER A 359
GLY A  11
 None
None
None
None
NDP  A 501 (-3.7A)
 1.25A 6mn8A-4rl6A:
undetectable		 6mn8A-4rl6A:
23.78