SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		5 / 10 ILE A  49
LEU A  70
VAL A  90
GLY A  91
GLY A  73
 None
None
C8E  A 309 (-4.8A)
None
None
 1.25A 2wd9C-4rl8A:
undetectable		 2wd9C-4rl8A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		3 / 3 LEU A 262
TYR A  22
GLN A  23
 None
 0.69A 2wekA-4rl8A:
undetectable		 2wekA-4rl8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		3 / 3 TYR A 144
ASP A 155
ASP A 108
 C8E  A 301 (-3.6A)
None
C8E  A 301 (-4.0A)
 0.83A 5x6yA-4rl8A:
undetectable		 5x6yA-4rl8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.44A 6g31A-4rl8A:
undetectable		 6g31A-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 6 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.40A 6g31B-4rl8A:
undetectable		 6g31B-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.29A 6g31D-4rl8A:
undetectable		 6g31D-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 5 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.27A 6g31F-4rl8A:
undetectable		 6g31F-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.28A 6g31G-4rl8A:
undetectable		 6g31G-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 5 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.40A 6g31H-4rl8A:
undetectable		 6g31H-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN
(Pseudomonas
putida) 		4 / 6 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.43A 6g31L-4rl8A:
undetectable		 6g31L-4rl8A:
14.80