SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 0.94A 1hxwA-4rlbA:
undetectable		 1hxwA-4rlbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		6 / 9 GLY A 196
ASP A 201
GLY A 192
ILE A 188
VAL A 120
ILE A 122
 None
 1.21A 1hxwA-4rlbA:
undetectable		 1hxwA-4rlbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		4 / 6 GLU A 203
GLN A 107
LYS A 177
VAL A 178
 None
 1.24A 1l2iB-4rlbA:
undetectable		 1l2iB-4rlbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		6 / 12 GLY A 196
ASP A 201
GLY A 192
ILE A 188
VAL A 120
ILE A 122
 None
 1.37A 1muiB-4rlbA:
undetectable		 1muiB-4rlbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 11 GLY A 189
ASP A 191
THR A 198
ILE A 122
ARG A 126
 None
 1.45A 2f9wA-4rlbA:
undetectable
2f9wB-4rlbA:
undetectable		 2f9wA-4rlbA:
23.05
2f9wB-4rlbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 TYR A 108
LEU A 140
ASP A 143
VAL A 104
ALA A 170
 None
 1.45A 2g70A-4rlbA:
undetectable		 2g70A-4rlbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 TYR A 108
LEU A 140
ASP A 143
VAL A 104
ALA A 170
 None
 1.41A 2g72A-4rlbA:
undetectable		 2g72A-4rlbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 ASP A 201
GLY A 192
ILE A 188
VAL A 120
ILE A 122
 None
 0.95A 2q5kA-4rlbA:
undetectable		 2q5kA-4rlbA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 1.04A 3ektA-4rlbA:
undetectable		 3ektA-4rlbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 1.07A 3gguB-4rlbA:
undetectable		 3gguB-4rlbA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		3 / 3 TYR A  76
TYR A 171
GLU A  80
 None
 0.98A 3pfgA-4rlbA:
undetectable		 3pfgA-4rlbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 0.93A 3u7sA-4rlbA:
undetectable		 3u7sA-4rlbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 0.95A 3u7sB-4rlbA:
undetectable		 3u7sB-4rlbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 9 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 1.07A 4dqcB-4rlbA:
undetectable		 4dqcB-4rlbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 LEU A  35
GLY A 151
ALA A  45
PHE A 165
GLY A 218
 None
 1.00A 4n09D-4rlbA:
undetectable		 4n09D-4rlbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 10 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 1.02A 4njtB-4rlbA:
undetectable		 4njtB-4rlbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 11 GLY A 196
ASP A 201
ASP A 123
GLY A 192
ILE A 188
 None
 0.97A 4njvB-4rlbA:
undetectable		 4njvB-4rlbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLY A 151
GLY A 100
ALA A  99
ILE A 146
TYR A 103
 None
 1.00A 4rtmA-4rlbA:
undetectable		 4rtmA-4rlbA:
21.78