SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 9 GLU A 164
GLY A 163
SER A 152
SER A 311
ASP A 171
 None
 1.26A 1m4iB-4rldA:
0.0		 1m4iB-4rldA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 10 GLY A 169
GLY A 168
ILE A 146
VAL A   4
ILE A 165
 None
 0.96A 1sdtA-4rldA:
7.1		 1sdtA-4rldA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		4 / 6 PHE A  31
ILE A 123
VAL A 136
PHE A 140
 None
 0.95A 2cizA-4rldA:
undetectable		 2cizA-4rldA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 VAL A  30
ASP A  32
SER A  35
VAL A 120
ASP A 215
 None
 0.66A 2v0zC-4rldA:
37.2		 2v0zC-4rldA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		3 / 3 LEU A 131
GLU A  86
ILE A  85
 None
 0.54A 3czhA-4rldA:
undetectable		 3czhA-4rldA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 11 VAL A  38
PHE A 167
ILE A 123
LEU A  89
PHE A 140
 None
 1.01A 3t3rA-4rldA:
undetectable		 3t3rA-4rldA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 VAL A  39
ALA A  41
LEU A  53
SER A  79
VAL A 120
 None
 1.01A 4eckB-4rldA:
undetectable		 4eckB-4rldA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		4 / 5 ILE A 114
LEU A 115
ASP A  76
VAL A  39
 None
 0.85A 4nkxB-4rldA:
undetectable		 4nkxB-4rldA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 11 LEU A 107
ALA A  49
LEU A  53
VAL A  30
LEU A 115
 None
 1.03A 4p65C-4rldA:
undetectable
4p65D-4rldA:
undetectable
4p65J-4rldA:
undetectable
4p65L-4rldA:
undetectable		 4p65C-4rldA:
5.36
4p65D-4rldA:
9.95
4p65J-4rldA:
9.95
4p65L-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 11 LEU A  53
VAL A  30
LEU A 115
LEU A 107
ALA A  49
 None
 1.00A 4p65B-4rldA:
undetectable
4p65D-4rldA:
undetectable
4p65G-4rldA:
undetectable
4p65H-4rldA:
undetectable		 4p65B-4rldA:
9.95
4p65D-4rldA:
9.95
4p65G-4rldA:
5.36
4p65H-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 VAL A  30
LEU A 115
LEU A  53
LEU A 107
ALA A  49
 None
 1.02A 4p65B-4rldA:
undetectable
4p65D-4rldA:
undetectable
4p65I-4rldA:
undetectable
4p65J-4rldA:
undetectable		 4p65B-4rldA:
9.95
4p65D-4rldA:
9.95
4p65I-4rldA:
5.36
4p65J-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 LEU A  53
VAL A  30
LEU A 115
LEU A 107
ALA A  49
 None
 1.03A 4p65F-4rldA:
undetectable
4p65H-4rldA:
undetectable
4p65K-4rldA:
undetectable
4p65L-4rldA:
undetectable		 4p65F-4rldA:
9.95
4p65H-4rldA:
9.95
4p65K-4rldA:
5.36
4p65L-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 GLY A 302
ALA A 212
HIS A 308
VAL A 306
ILE A 153
 None
None
NAG  A 501 (-4.3A)
None
None
 0.95A 4rvdA-4rldA:
undetectable		 4rvdA-4rldA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		3 / 3 ASN A 263
PHE A 179
TYR A 309
 None
None
NAG  A 501 (-4.6A)
 0.84A 4u15A-4rldA:
undetectable		 4u15A-4rldA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		4 / 4 GLY A  16
VAL A   4
PHE A 313
ILE A 153
 None
 1.00A 4xv2B-4rldA:
undetectable		 4xv2B-4rldA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 PHE A 151
SER A  33
ILE A 213
SER A 189
VAL A 182
 None
 1.42A 5h1eA-4rldA:
undetectable		 5h1eA-4rldA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 10 ILE A 123
ILE A 165
VAL A 121
THR A  29
ILE A  91
 None
 1.29A 5lg3F-4rldA:
undetectable		 5lg3F-4rldA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 10 ILE A 123
ILE A 165
VAL A 121
THR A  29
ILE A  91
 None
 1.27A 5lg3H-4rldA:
undetectable		 5lg3H-4rldA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4rld ASPARTIC PROTEASE
BLA G 2
(Blattella
germanica) 		5 / 12 VAL A   4
VAL A   2
PHE A  31
SER A  92
PHE A 140
 None
 1.39A 6h7mB-4rldA:
undetectable		 6h7mB-4rldA:
12.96