SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4rle UNCHARACTERIZED
PROTEIN YAAQ
(Bacillus
subtilis) 		3 / 3 ARG A  67
GLY A  64
ASP A  12
 None
 0.59A 1kf6A-4rleA:
undetectable
1kf6B-4rleA:
undetectable		 1kf6A-4rleA:
10.95
1kf6B-4rleA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4rle UNCHARACTERIZED
PROTEIN YAAQ
(Bacillus
subtilis) 		4 / 7 LEU A 101
THR A  97
LEU A   3
VAL A   7
 None
 0.96A 1tyrB-4rleA:
undetectable		 1tyrB-4rleA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rle UNCHARACTERIZED
PROTEIN YAAQ
(Bacillus
subtilis) 		4 / 6 ILE A  60
ILE A  51
PHE A  25
HIS A  23
 None
 0.97A 5vkqA-4rleA:
undetectable
5vkqB-4rleA:
undetectable		 5vkqA-4rleA:
5.73
5vkqB-4rleA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4rle UNCHARACTERIZED
PROTEIN YAAQ
(Bacillus
subtilis) 		4 / 6 ILE A  60
ILE A  51
PHE A  25
HIS A  23
 None
 0.96A 5vkqA-4rleA:
undetectable
5vkqD-4rleA:
undetectable		 5vkqA-4rleA:
5.73
5vkqD-4rleA:
5.73