SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 134
VAL A 127
CYH A 105
ALA A  67
 None
 1.12A 1mz9E-4rltA:
undetectable		 1mz9E-4rltA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 5 SER B 110
SER B 117
VAL B 111
SER B 138
 None
 1.38A 2j9cA-4rltB:
undetectable
2j9cB-4rltB:
undetectable
2j9cC-4rltB:
undetectable		 2j9cA-4rltB:
26.42
2j9cB-4rltB:
26.42
2j9cC-4rltB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 7 SER B 110
SER B 117
VAL B 111
SER B 138
 None
 1.38A 2j9cA-4rltB:
undetectable
2j9cB-4rltB:
undetectable
2j9cC-4rltB:
undetectable		 2j9cA-4rltB:
26.42
2j9cB-4rltB:
26.42
2j9cC-4rltB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 8 ALA B 121
ALA B 135
GLY B  67
ALA B 137
 None
 0.76A 2vh3B-4rltB:
undetectable		 2vh3B-4rltB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		5 / 11 THR A 123
VAL A 109
VAL A  85
ILE A  84
THR A 118
 None
 1.44A 3elzB-4rltA:
1.8		 3elzB-4rltA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		5 / 12 THR A 123
VAL A 109
VAL A  85
ILE A  84
THR A 118
 None
 1.45A 3elzC-4rltA:
undetectable		 3elzC-4rltA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 4 LEU B 102
ALA B 100
VAL B  93
PRO B  92
 None
 1.11A 3gv1B-4rltB:
undetectable		 3gv1B-4rltB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.91A 3p50A-4rltA:
undetectable		 3p50A-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50B-4rltA:
undetectable		 3p50B-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50C-4rltA:
undetectable		 3p50C-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50D-4rltA:
undetectable		 3p50D-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.95A 3p50E-4rltA:
undetectable		 3p50E-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 7 ILE B  40
GLY B  59
THR B  62
LEU B  22
 None
 0.86A 4zdzA-4rltB:
undetectable		 4zdzA-4rltB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 8 ILE B  40
GLY B  59
THR B  62
LEU B  22
 None
 0.93A 5esjA-4rltB:
undetectable		 5esjA-4rltB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		5 / 11 PHE A  71
ILE A  84
VAL A 112
VAL A   8
MET A  10
 None
 1.46A 5jkwA-4rltA:
undetectable		 5jkwA-4rltA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.34A 5l5zV-4rltA:
undetectable
5l5zW-4rltA:
undetectable		 5l5zV-4rltA:
21.27
5l5zW-4rltA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.25A 5l66H-4rltA:
undetectable
5l66I-4rltA:
undetectable		 5l66H-4rltA:
21.27
5l66I-4rltA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.24A 5l66V-4rltA:
undetectable
5l66W-4rltA:
undetectable		 5l66V-4rltA:
21.27
5l66W-4rltA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 10 ILE B 120
TRP A  38
GLY B  67
GLY B  66
TYR B  20
 None
 1.37A 5lbtA-4rltB:
undetectable
5lbtB-4rltB:
undetectable		 5lbtA-4rltB:
21.74
5lbtB-4rltB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		4 / 8 ILE B 131
VAL B  91
TYR B  20
ILE B  65
 None
 0.96A 5mzrE-4rltB:
undetectable		 5mzrE-4rltB:
23.33