SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2240
LEU A2212
LEU A2252
LEU A2196
ARG A2228
 None
 0.99A 2ceoA-4rlyA:
undetectable		 2ceoA-4rlyA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A2035
VAL A2048
LEU A2044
ALA A2038
 None
 0.99A 2e1qA-4rlyA:
undetectable		 2e1qA-4rlyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A2035
VAL A2048
LEU A2044
ALA A2038
 None
 0.94A 2e1qC-4rlyA:
undetectable		 2e1qC-4rlyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 10 ALA A2240
LEU A2212
LEU A2252
LEU A2196
ARG A2228
 None
 1.04A 2riwA-4rlyA:
undetectable
2riwB-4rlyA:
undetectable		 2riwA-4rlyA:
24.27
2riwB-4rlyA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 10 ALA A2240
LEU A2212
LEU A2252
LEU A2196
ARG A2228
 None
 0.93A 2xn6A-4rlyA:
undetectable
2xn6B-4rlyA:
undetectable		 2xn6A-4rlyA:
23.53
2xn6B-4rlyA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO A2236
LEU A2252
ARG A2255
 None
None
SO4  A2406 ( 4.9A)
 0.66A 3aqiB-4rlyA:
undetectable		 3aqiB-4rlyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO A2269
LEU A2285
ARG A2288
 None
 0.64A 3aqiB-4rlyA:
undetectable		 3aqiB-4rlyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 12 LEU A2210
LEU A2211
ALA A2208
LEU A2167
GLY A2163
 None
 1.07A 3olsA-4rlyA:
undetectable		 3olsA-4rlyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 HIS A2069
SER A1124
GLU A1123
 None
 0.93A 3s8pA-4rlyA:
undetectable		 3s8pA-4rlyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 SO4  A2406 (-4.2A)
None
None
None
None
 1.07A 4wg0F-4rlyA:
undetectable
4wg0G-4rlyA:
undetectable
4wg0H-4rlyA:
undetectable		 4wg0F-4rlyA:
6.31
4wg0G-4rlyA:
6.31
4wg0H-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2116
GLU A2082
LEU A2084
ALA A2067
LEU A2068
 None
 1.16A 4wg0H-4rlyA:
undetectable
4wg0I-4rlyA:
undetectable
4wg0J-4rlyA:
undetectable		 4wg0H-4rlyA:
6.31
4wg0I-4rlyA:
6.31
4wg0J-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 SO4  A2406 (-4.2A)
None
None
None
None
 1.04A 4wg0H-4rlyA:
undetectable
4wg0I-4rlyA:
undetectable
4wg0J-4rlyA:
undetectable		 4wg0H-4rlyA:
6.31
4wg0I-4rlyA:
6.31
4wg0J-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 SO4  A2406 (-4.2A)
None
None
None
None
 1.02A 4wg0J-4rlyA:
undetectable
4wg0K-4rlyA:
undetectable
4wg0L-4rlyA:
undetectable		 4wg0J-4rlyA:
6.31
4wg0K-4rlyA:
6.31
4wg0L-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2195
LEU A2196
LEU A2212
LEU A2251
LEU A2252
 None
None
None
SO4  A2406 (-4.2A)
None
 1.01A 4wg0I-4rlyA:
undetectable
4wg0J-4rlyA:
undetectable
4wg0K-4rlyA:
undetectable		 4wg0I-4rlyA:
6.31
4wg0J-4rlyA:
6.31
4wg0K-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2067
LEU A2068
GLU A2082
LEU A2084
LEU A2116
 None
 1.05A 4wg0K-4rlyA:
undetectable
4wg0L-4rlyA:
undetectable
4wg0M-4rlyA:
undetectable		 4wg0K-4rlyA:
6.31
4wg0L-4rlyA:
6.31
4wg0M-4rlyA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rly NAV1.2 - ANKB
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2195
LEU A2196
LEU A2212
LEU A2251
LEU A2252
 None
None
None
SO4  A2406 (-4.2A)
None
 1.04A 4wg0K-4rlyA:
undetectable
4wg0L-4rlyA:
undetectable
4wg0M-4rlyA:
undetectable		 4wg0K-4rlyA:
6.31
4wg0L-4rlyA:
6.31
4wg0M-4rlyA:
6.31