SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 524
ILE A 483
ARG A 481
ILE A 494
LEU A 429
 None
 1.23A 1tw4B-4rlzA:
undetectable		 1tw4B-4rlzA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 PHE A 326
VAL A 435
THR A 273
LEU A 402
TYR A 405
 None
 1.18A 2cbrA-4rlzA:
undetectable		 2cbrA-4rlzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		4 / 4 LEU A 449
ASP A 267
VAL A 455
THR A 274
 None
 1.17A 3cyxB-4rlzA:
undetectable		 3cyxB-4rlzA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 GLY A 308
VAL A 304
PRO A 306
ASN A 307
 None
 0.81A 4forA-4rlzA:
undetectable		 4forA-4rlzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 PHE A 397
ILE A 444
PHE A 240
ASN A 237
 None
 1.19A 4o7gA-4rlzA:
undetectable
4o7gB-4rlzA:
undetectable		 4o7gA-4rlzA:
22.91
4o7gB-4rlzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 300
GLY A 368
ILE A 376
LEU A 334
THR A 288
 None
 1.30A 5b8hA-4rlzA:
undetectable
5b8hB-4rlzA:
undetectable		 5b8hA-4rlzA:
22.38
5b8hB-4rlzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4rlz CAPSID PROTEIN
(Norwalk
virus) 		4 / 5 ASN A 394
VAL A 351
LEU A 369
SER A 357
 GOL  A 601 (-3.3A)
None
None
GOL  A 601 (-4.7A)
 1.22A 6a7pA-4rlzA:
undetectable		 6a7pA-4rlzA:
17.54