SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.12A 1ddrB-4rm4A:
undetectable		 1ddrB-4rm4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.13A 1jolA-4rm4A:
undetectable		 1jolA-4rm4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.13A 1jolB-4rm4A:
undetectable		 1jolB-4rm4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 6 GLU A 358
LEU A 354
LEU A 148
GLY A 149
 None
HEM  A 401 (-4.7A)
None
None
 0.92A 1n13H-4rm4A:
undetectable
1n13K-4rm4A:
undetectable		 1n13H-4rm4A:
14.87
1n13K-4rm4A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 7 GLN A 157
ILE A 198
VAL A 150
PRO A 151
 None
 1.08A 1rxcD-4rm4A:
undetectable		 1rxcD-4rm4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 7 GLN A 157
ILE A 198
VAL A 150
PRO A 151
 None
 1.08A 1rxcF-4rm4A:
undetectable		 1rxcF-4rm4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.11A 1tdrA-4rm4A:
undetectable		 1tdrA-4rm4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 4 PHE A 392
ASP A 134
PHE A 129
VAL A 394
 None
 1.28A 1w0fA-4rm4A:
31.2		 1w0fA-4rm4A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 6 ARG A 184
ASN A  79
ASN A  45
LEU A 311
 None
 1.17A 2nyrA-4rm4A:
undetectable		 2nyrA-4rm4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 4 VAL A 238
ARG A  93
ILE A 210
THR A 243
 None
HEM  A 401 (-3.9A)
None
HEM  A 401 (-3.7A)
 1.39A 3cl9A-4rm4A:
undetectable		 3cl9A-4rm4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		3 / 3 ALA A 239
THR A 243
CYH A 349
 HEM  A 401 (-3.6A)
HEM  A 401 (-3.7A)
HEM  A 401 (-2.3A)
 0.50A 3e4eA-4rm4A:
30.2		 3e4eA-4rm4A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		3 / 3 ALA A 239
THR A 243
CYH A 349
 HEM  A 401 (-3.6A)
HEM  A 401 (-3.7A)
HEM  A 401 (-2.3A)
 0.45A 3e4eB-4rm4A:
30.1		 3e4eB-4rm4A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.15A 3ql0A-4rm4A:
undetectable		 3ql0A-4rm4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 5 SER A 316
PRO A 287
TYR A 387
VAL A 288
 None
 1.42A 3sufC-4rm4A:
undetectable		 3sufC-4rm4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 PRO A 138
LEU A 119
LEU A 366
ILE A 248
TYR A 262
 None
 1.22A 4a79A-4rm4A:
undetectable		 4a79A-4rm4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 PRO A 138
LEU A 119
LEU A 366
ILE A 248
TYR A 262
 None
 1.19A 4a79B-4rm4A:
undetectable		 4a79B-4rm4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 8 SER A 249
MET A 252
ILE A 248
PHE A 135
 None
 1.18A 4cx7C-4rm4A:
0.0
4cx7D-4rm4A:
undetectable		 4cx7C-4rm4A:
21.41
4cx7D-4rm4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 7 GLN A 157
ILE A 198
VAL A 150
PRO A 151
 None
 1.07A 4e1vB-4rm4A:
undetectable		 4e1vB-4rm4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 LEU A 354
ALA A 355
LEU A 236
ILE A  82
LEU A 235
 HEM  A 401 (-4.7A)
HEM  A 401 (-3.5A)
HEM  A 401 ( 4.1A)
HEM  A 401 (-4.0A)
HEM  A 401 ( 4.4A)
 1.15A 4j24D-4rm4A:
undetectable		 4j24D-4rm4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 6 ILE A 248
SER A 136
PHE A 123
LEU A 119
 None
 0.92A 4m51A-4rm4A:
undetectable		 4m51A-4rm4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 11 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.10A 4qlfA-4rm4A:
undetectable		 4qlfA-4rm4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.17A 4qlgA-4rm4A:
undetectable		 4qlgA-4rm4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.13A 4qlgB-4rm4A:
undetectable		 4qlgB-4rm4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ALA A 286
ILE A 386
ILE A  82
ASN A  83
ASN A  79
 HEM  A 401 ( 4.5A)
None
HEM  A 401 (-4.0A)
None
None
 1.18A 4r3aA-4rm4A:
undetectable		 4r3aA-4rm4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.20A 4rgcA-4rm4A:
undetectable		 4rgcA-4rm4A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.15A 4x5hA-4rm4A:
undetectable		 4x5hA-4rm4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.07A 5e8qB-4rm4A:
undetectable		 5e8qB-4rm4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.07A 5eajB-4rm4A:
undetectable		 5eajB-4rm4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		3 / 3 PRO A 327
ARG A 319
GLU A 321
 None
 0.74A 5j6hA-4rm4A:
undetectable		 5j6hA-4rm4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ALA A 355
GLY A 351
LEU A 357
ALA A 359
PRO A 273
 HEM  A 401 (-3.5A)
HEM  A 401 (-3.5A)
None
None
None
 0.90A 5jglB-4rm4A:
undetectable		 5jglB-4rm4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		4 / 8 LEU A 236
PHE A 100
LEU A 214
ILE A 213
 HEM  A 401 ( 4.1A)
None
None
None
 0.98A 5mzjA-4rm4A:
undetectable		 5mzjA-4rm4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		5 / 12 ILE A  81
LEU A 229
PHE A 232
ILE A 210
LEU A 236
 HEM  A 401 (-4.3A)
None
None
None
HEM  A 401 ( 4.1A)
 1.07A 5ujxB-4rm4A:
undetectable		 5ujxB-4rm4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4rm4 CYTOCHROME P450
(Bacillus
subtilis) 		3 / 3 TYR A 262
HIS A 372
MET A 396
 None
 1.22A 6af6A-4rm4A:
2.6		 6af6A-4rm4A:
20.00