SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.13A 1fduA-4rm9A:
undetectable		 1fduA-4rm9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.11A 1fduC-4rm9A:
undetectable		 1fduC-4rm9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 12 ASN A 226
LEU A 218
GLY A 219
THR A 567
ILE A 571
 None
 1.43A 1p93A-4rm9A:
undetectable		 1p93A-4rm9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 10 LEU A 125
ALA A 129
LEU A 192
ILE A 115
LEU A 111
 None
 1.27A 1pcgA-4rm9A:
2.9		 1pcgA-4rm9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 8 TYR A 270
ASN A 210
LYS A 211
LYS A 212
 None
 1.46A 3bjwD-4rm9A:
undetectable		 3bjwD-4rm9A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 8 ARG A 569
ASP A 197
GLN A 196
GLU A 190
 None
 1.14A 3dh0A-4rm9A:
undetectable		 3dh0A-4rm9A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		6 / 12 LEU A 125
ALA A 129
LEU A 192
ILE A 115
GLY A 109
LEU A 111
 None
 1.21A 3q95A-4rm9A:
undetectable		 3q95A-4rm9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 12 LEU A 125
ALA A 129
ILE A 115
GLY A 109
LEU A 111
 None
 0.87A 3q95B-4rm9A:
3.3		 3q95B-4rm9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 11 LEU A 125
ALA A 129
LEU A 192
GLY A 109
LEU A 111
 None
 1.14A 3uudA-4rm9A:
undetectable		 3uudA-4rm9A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 4 ILE A 153
HIS A 161
MET A 158
ARG A 171
 None
 1.43A 4acbB-4rm9A:
0.0
4acbC-4rm9A:
0.0		 4acbB-4rm9A:
23.14
4acbC-4rm9A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 12 LEU A 125
ALA A 129
LEU A 192
GLY A 109
LEU A 111
 None
 1.12A 4pxmA-4rm9A:
3.5		 4pxmA-4rm9A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.21A 4yv5B-4rm9A:
undetectable		 4yv5B-4rm9A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.23A 4yv5A-4rm9A:
undetectable		 4yv5A-4rm9A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4rm9 EZRIN
(Homo
sapiens) 		4 / 6 ILE A 110
ALA A 122
LEU A 125
ILE A 194
 None
 0.88A 5mvmB-4rm9A:
undetectable
5mvmC-4rm9A:
undetectable		 5mvmB-4rm9A:
9.20
5mvmC-4rm9A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4rm9 EZRIN
(Homo
sapiens) 		6 / 12 LEU A 538
VAL A 157
ILE A 172
LEU A 534
PRO A 154
LEU A 125
 None
 1.49A 5og9B-4rm9A:
undetectable		 5og9B-4rm9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4rm9 EZRIN
(Homo
sapiens) 		3 / 3 TYR A 146
ALA A 177
TYR A 137
 None
 0.41A 5uunB-4rm9A:
undetectable		 5uunB-4rm9A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4rm9 EZRIN
(Homo
sapiens) 		5 / 10 LEU A 223
ALA A 222
GLU A  87
ARG A 295
ILE A 248
 None
 1.37A 6cbzB-4rm9A:
undetectable		 6cbzB-4rm9A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4rm9 EZRIN
(Homo
sapiens) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 None
 0.64A 6g1pA-4rm9A:
undetectable		 6g1pA-4rm9A:
20.48