SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rma EZRIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.08A 1fduA-4rmaA:
undetectable		 1fduA-4rmaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rma EZRIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.07A 1fduC-4rmaA:
undetectable		 1fduC-4rmaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4rma EZRIN
(Homo
sapiens) 		5 / 10 LEU A 125
ALA A 129
LEU A 192
ILE A 115
LEU A 111
 None
 1.34A 1pcgA-4rmaA:
undetectable		 1pcgA-4rmaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4rma EZRIN
(Homo
sapiens) 		5 / 12 ILE A 245
ILE A 257
ASP A 221
VAL A 220
LEU A 218
 None
 1.01A 1qhyA-4rmaA:
undetectable		 1qhyA-4rmaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4rma EZRIN
(Homo
sapiens) 		5 / 12 VAL A  42
THR A  36
LEU A  16
LEU A  61
PHE A  18
 None
 1.24A 2jn3A-4rmaA:
undetectable		 2jn3A-4rmaA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4rma EZRIN
(Homo
sapiens) 		5 / 10 TYR A 128
HIS A 176
ALA A 129
ALA A 187
ALA A 132
 None
 1.28A 2r2vC-4rmaA:
undetectable
2r2vF-4rmaA:
undetectable
2r2vG-4rmaA:
undetectable		 2r2vC-4rmaA:
15.23
2r2vF-4rmaA:
15.23
2r2vG-4rmaA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4rma EZRIN
(Homo
sapiens) 		4 / 4 VAL A   7
PHE A  78
PHE A  80
VAL A  34
 None
 1.41A 3rv5C-4rmaA:
undetectable
3rv5D-4rmaA:
undetectable		 3rv5C-4rmaA:
16.96
3rv5D-4rmaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4rma EZRIN
(Homo
sapiens) 		4 / 5 ILE A 110
ILE A 194
TYR A 191
GLU A 190
 None
 1.20A 4a99D-4rmaA:
undetectable		 4a99D-4rmaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4rma EZRIN
(Homo
sapiens) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.15A 4yv5B-4rmaA:
undetectable		 4yv5B-4rmaA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4rma EZRIN
(Homo
sapiens) 		4 / 6 PHE A  18
LEU A  76
ASN A  74
PRO A  75
 None
 1.17A 4yv5A-4rmaA:
undetectable		 4yv5A-4rmaA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rma EZRIN
(Homo
sapiens) 		5 / 12 ILE A 238
GLY A 239
SER A 249
ILE A 248
PHE A 255
 None
 0.97A 5igwA-4rmaA:
2.0		 5igwA-4rmaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4rma EZRIN
(Homo
sapiens) 		3 / 3 TYR A 146
ALA A 177
TYR A 137
 None
 0.48A 5uunB-4rmaA:
undetectable		 5uunB-4rmaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rma EZRIN
(Homo
sapiens) 		4 / 7 ALA A 122
THR A 121
GLN A 160
VAL A 157
 None
 0.94A 6cduA-4rmaA:
undetectable
6cduE-4rmaA:
undetectable		 6cduA-4rmaA:
17.54
6cduE-4rmaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rma EZRIN
(Homo
sapiens) 		4 / 6 GLN A 160
VAL A 157
ALA A 122
THR A 121
 None
 0.93A 6cduB-4rmaA:
undetectable
6cduC-4rmaA:
undetectable		 6cduB-4rmaA:
17.54
6cduC-4rmaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rma EZRIN
(Homo
sapiens) 		4 / 7 GLN A 160
VAL A 157
ALA A 122
THR A 121
 None
 0.89A 6cduC-4rmaA:
undetectable
6cduD-4rmaA:
undetectable		 6cduC-4rmaA:
17.54
6cduD-4rmaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rma EZRIN
(Homo
sapiens) 		4 / 7 GLN A 160
VAL A 157
ALA A 122
THR A 121
 None
 0.93A 6cduH-4rmaA:
undetectable
6cduI-4rmaA:
undetectable		 6cduH-4rmaA:
17.54
6cduI-4rmaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4rma EZRIN
(Homo
sapiens) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 None
 0.77A 6g1pA-4rmaA:
undetectable		 6g1pA-4rmaA:
21.11