SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4rmb SERINE RICH REPEAT
PROTEIN-1 (SRR-1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
 0.96A 3clbA-4rmbA:
undetectable		 3clbA-4rmbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4rmb SERINE RICH REPEAT
PROTEIN-1 (SRR-1)
(Streptococcus
agalactiae) 		5 / 12 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
 0.97A 3clbC-4rmbA:
undetectable		 3clbC-4rmbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rmb SERINE RICH REPEAT
PROTEIN-1 (SRR-1)
(Streptococcus
agalactiae) 		5 / 10 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
 0.98A 3hbbA-4rmbA:
undetectable		 3hbbA-4rmbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rmb SERINE RICH REPEAT
PROTEIN-1 (SRR-1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
 1.00A 3hbbC-4rmbA:
undetectable		 3hbbC-4rmbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4rmb SERINE RICH REPEAT
PROTEIN-1 (SRR-1)
(Streptococcus
agalactiae) 		4 / 8 TYR A 569
VAL A 565
VAL A 594
GLN A 501
 None
 0.80A 3hjoA-4rmbA:
undetectable		 3hjoA-4rmbA:
24.19